The VHL tumour-suppressor gene paradigm

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

Mutations of the VHL tumour suppressor gene in renal carcinoma

1994 • 1,719 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

1997 • 1,059 citations

Clinical Features and Natural History of von Hippel-Lindau Disease

1990 • 916 citations

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.

1996 • 886 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Tumour suppression by the human von Hippel-Lindau gene product

1995 • 705 citations

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

1995 • 672 citations

Human Cancer Syndromes: Clues to the Origin and Nature of Cancer

1997 • 612 citations

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

1995 • 571 citations

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: Correlations with phenotype

1995 • 552 citations

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.

1996 • 541 citations

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

1998 • 512 citations

von Hippel-Lindau Disease

1997 • 506 citations

Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan

1996 • 490 citations

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1997 • 490 citations

Identification of intragenic mutations in the Von Hippel — Lindau disease tumour suppressor gene andcorrelation with disease phenotype

1994 • 386 citations

Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2

1998 • 377 citations

Somatic mutations of the von Hippel — Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

1994 • 371 citations

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1997 • 359 citations

The von Hippel-Lindau Tumor Suppressor Gene Product Interacts with Sp1 To Repress Vascular Endothelial Growth Factor Promoter Activity

1997 • 345 citations

Elongin (SIII): A Multisubunit Regulator of Elongation by RNA Polymerase II

1995 • 320 citations

Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein.

1996 • 315 citations

The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression

1996 • 287 citations

Integrin-mediated adhesion and signaling in tumorigenesis

1994 • 203 citations

Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients.

1996 • 187 citations

Von Hippel-Lindau (VHL) disease with pheochromocytoma in the Black Forest region of Germany: evidence for a founder effect

1995 • 177 citations

Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas.

1995 • 171 citations

Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations.

1995 • 154 citations

Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours

1994 • 150 citations

Signaling by integrins: implications for tumorigenesis.

1993 • 150 citations

A polymeric form of fibronectin has antimetastatic effects against multiple tumor types

1996 • 133 citations

Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues

1997 • 124 citations

Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product.

1996 • 120 citations

The Interaction of an Epidermal Growth Factor/Transforming Growth Factor α Tail Chimera with the Human Epidermal Growth Factor Receptor Reveals Unexpected Complexities

1996 • 110 citations

Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene.

1995 • 107 citations

Consequences of Direct Genetic Testing for Germline Mutations in the Clinical Management of Families With Multiple Endocrine Neoplasia, Type II

1995 • 103 citations

The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex.

1996 • 100 citations

Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis

1996 • 100 citations

Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines.

1994 • 96 citations

Consequences of direct genetic testing for germline mutations in the clinical management of families with multiple endocrine neoplasia, type II

1995 • 34 citations

Molecular genetic analysis of the von Hippel-Lindau disease (VHl) tumour suppressor gene in gonadal tumours

1995 • 24 citations