Hormone regulation of chondrocyte differentiation and endochondral bone formation

Williams Textbook of Endocrinology

2016 • 3,772 citations

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1994 • 2,443 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

1998 • 1,753 citations

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1995 • 1,380 citations

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens.

1995 • 1,354 citations

PTH/PTHrP Receptor in Early Development and Indian Hedgehog—Regulated Bone Growth

1996 • 1,303 citations

Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning

1997 • 1,149 citations

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

1994 • 1,138 citations

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1993 • 804 citations

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

1997 • 784 citations

Histology. A Text and Atlas.

1974 • 730 citations

A Constitutively Active Mutant PTH-PTHrP Receptor in Jansen-Type Metaphyseal Chondrodysplasia

1995 • 668 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 644 citations

Function of retinoic acid receptor γ in the mouse

1993 • 595 citations

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens

1995 • 568 citations

25-Hydroxyvitamin D ₃ 1α-Hydroxylase and Vitamin D Synthesis

1997 • 528 citations

Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage

1997 • 504 citations

Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

1996 • 471 citations

Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation.

1994 • 455 citations

Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.

1996 • 432 citations

Cloning of Human 25-Hydroxyvitamin D-1α-Hydroxylase and Mutations Causing Vitamin D-Dependent Rickets Type 1

1997 • 398 citations

Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes.

1996 • 371 citations

Inactivating Mutations in the 25-Hydroxyvitamin D₃1α-Hydroxylase Gene in Patients with Pseudovitamin D–Deficiency Rickets

1998 • 360 citations

Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide

1997 • 360 citations

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

1990 • 351 citations

Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair

1998 • 348 citations

The T3Ralpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production

1997 • 341 citations

Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development

1997 • 339 citations

A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom).

1994 • 332 citations

The 25-Hydroxyvitamin D 1-Alpha-Hydroxylase Gene Maps to the Pseudovitamin D-Deficiency Rickets (PDDR) Disease Locus

1997 • 318 citations

Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia.

1998 • 315 citations

Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development

1997 • 292 citations

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.

1996 • 277 citations

Developmental analysis of the retinoic acid-inducible RAR-βJ2 promoter in transgenic animals

1991 • 258 citations

Laron Dwarfism and Non-Insulin-Dependent Diabetes Mellitus in the Hnf-1α Knockout Mouse

1998 • 251 citations

The syndromes of resistance to thyroid hormone

1993 • 233 citations

Angiogenesis and rheumatoid arthritis: pathogenic and therapeutic implications.

1992 • 212 citations

Histology : a text and atlas

1974 • 192 citations

A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom)

1994 • 184 citations

Identification of Chondromodulin I as a Novel Endothelial Cell Growth Inhibitor

1997 • 184 citations

Endocrine regulation of longitudinal bone growth

1993 • 153 citations

Transferrin Promotes Endothelial Cell Migration and Invasion: Implication in Cartilage Neovascularization

1997 • 138 citations

Mice lacking all isoforms of retinoic acid receptor β develop normally and are susceptible to the teratogenic effects of retinoic acid

1995 • 132 citations

Cloning of Human 25-Hydroxyvitamin D-1 -Hydroxylase and Mutations Causing Vitamin D-Dependent Rickets Type 1

1997 • 125 citations

Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis1This work was presented in part at the 43rd Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, February 1997.1

1997 • 115 citations

Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro.

1992 • 109 citations

EFFECT OF THYROID HORMONE ON GROWTH

1996 • 97 citations

Retinoic Acid Receptor α Function in Vertebrate Limb Skeletogenesis: a Modulator of Chondrogenesis

1997 • 94 citations

A Novel Angiogenic Molecule Produced at the Time of Chondrocyte Hypertrophy during Endochondral Bone Formation

1996 • 93 citations

Neovascularisation and its role in the osteoarthritic process.

1988 • 80 citations

Parathyroid hormone-induced resorption in fetal rat limb bones is associated with production of the metalloproteinases collagenase and gelatinase B

1996 • 76 citations

Hormonal regulation of longitudinal bone growth

1986 • 76 citations

Chondrocytes inhibit endothelial sprout formation in vitro: Evidence for involvement of a transforming growth factor‐beta

1991 • 75 citations

Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth

1998 • 71 citations

Mouse embryos lacking RXRα are resistant to retinoic-acid-induced limb defects

1995 • 66 citations

Regulation of Tissue Inhibitor of Metalloproteinases-3 Gene Expression by Transforming Growth Factor-β and Dexamethasone in Bovine and Human Articular Chondrocytes

1996 • 64 citations

Effects of Parathyroid Hormone (PTH) and PTH-Related Peptide on Expressions of Matrix Metalloproteinase- 2, -3, and -9 in Growth Plate Chondrocyte Cultures*

1998 • 61 citations

Genetic Defects of the 1,25-Dihydroxyvitamin D₃Receptor

1991 • 58 citations

Role of 1,25-dihydroxycholecalciferol in growth-plate cartilage: inhibition of terminal differentiation of chondrocytes in vitro and in vivo.

1990 • 56 citations

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development

1996 • 56 citations

Chondrocyte cultures express matrix metalloproteinase mRNA and immunoreactive protein; stromelysin-1 and 72 kDa gelatinase are localized in extracellular matrix vesicles

1996 • 53 citations

Retinoids modify regulation of endogenous gene expression by vitamin D3 and thyroid hormone in three osteosarcoma cell lines.

1995 • 53 citations

4. Hormonal regulation of longitudinal bone growth

1994 • 53 citations

Vitamin D3 regulation of stromelysin-1 (MMP-3) in chondrocyte cultures is mediated by protein kinase C

1996 • 51 citations

Retinoid-Induced Epiphyseal Plate Closure in Guinea Pigs

1996 • 46 citations

Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) mRNA is constitutively expressed in bovine, human normal, and osteoarthritic articular chondrocytes

1996 • 44 citations

Growth hormone resistance.

1980 • 40 citations

Physiological Roles for Parathyroid Hormone-Related Protein: Lessons from Gene Knockout Mice

1996 • 37 citations

Tissue inhibitor of metalloproteinase-2 (TIMP-2) mRNA is constitutively expressed in bovine, human normal, and osteoarthritic articular chondrocytes

1996 • 37 citations

Thyroid hormone, vitamin D and retinoid receptor expression and signalling in primary cultures of rat osteoblastic and immortalised osteosarcoma cells

1997 • 34 citations

Production of Collagenase and Tissue Inhibitor of Metal loproteinases (TIMP) by Rat Growth Plates in Culture

1990 • 23 citations

Retinoids modify regulation of endogenous gene expression by vitamin D3 and thyroid hormone in three osteosarcoma cell lines

1995 • 22 citations

4 Vitamin D resistance

1994 • 16 citations

Effects of Parathyroid Hormone (PTH) and PTH-Related Peptide on Expressions of Matrix Metalloproteinase- 2, -3, and -9 in Growth Plate Chondrocyte Cultures

1998 • 12 citations