Agonist peptide from a cytotoxic t-lymphocyte epitope of human carcinoembryonic antigen stimulates production of tc1-type cytokines and increases tyrosine phosphorylation more efficiently than cognate peptide

DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES

1965 • 2,318 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1998 • 1,826 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

1995 • 506 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

A one-stage procedure for isolation of granulocytes and lymphocytes from human blood. General sedimentation properties of white blood cells in a 1g gravity field.

1968 • 492 citations

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1995 • 422 citations

An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.

1996 • 416 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA

1998 • 403 citations

Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone

1997 • 320 citations

A Phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen.

1999 • 299 citations

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

1993 • 277 citations

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

1995 • 236 citations

A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire.

1994 • 216 citations

Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen.

1997 • 210 citations

Phase I Study in Cancer Patients of a Replication-Defective Avipox Recombinant Vaccine That Expresses Human Carcinoembryonic Antigen

1999 • 201 citations

Manipulation of the Th1/Th2 balance in autoimmune disease

1996 • 186 citations

Definition by monoclonal antibodies of a repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinomas versus normal adult tissues.

1985 • 177 citations

Altered T Cell Receptor Ligands Trigger a Subset of Early T Cell Signals

1996 • 169 citations

A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens

1997 • 158 citations

Relationships Among TCR Ligand Potency, Thresholds for Effector Function Elicitation, and the Quality of Early Signaling Events in Human T Cells

1998 • 157 citations

Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine.

1995 • 141 citations

Partial signaling by CD8+ T cells in response to antagonist ligands.

1996 • 111 citations

A superagonist variant of peptide MART1/Melan A27-35 elicits anti-melanoma CD8+ T cells with enhanced functional characteristics: implication for more effective immunotherapy.

1999 • 97 citations

Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87–99)

1996 • 95 citations

Generation of Stable CD4+and CD8+T Cell Lines from Patients Immunized withrasOncogene-Derived Peptides Reflecting Codon 12 Mutations

1997 • 88 citations

Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: Implications for autoimmunity

1998 • 80 citations

Phenotypic stability of a cytotoxic T-cell line directed against an immunodominant epitope of human carcinoembryonic antigen.

1997 • 73 citations

Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands.

1997 • 71 citations

Peptides derived from self-proteins as partial agonists and antagonists of human CD8+ T-cell clones reactive to melanoma/melanocyte epitope MART1(27-35).

1998 • 71 citations

Dendritic Cells Pulsed with CEA Peptide Induce CEA-Specific CTL with Restricted TCR Repertoire

1998 • 61 citations

Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand.

1995 • 54 citations

RECOMBINANT CARCINOEMBRYONIC ANTIGEN AND GRANULOCY-TE-MACROPHAGE COLONY-STIMULATING FACTOR FOR ACTIVE IMMUNIZATION OF COLORECTAL CARCINOMA PATIENTS

1995 • 16 citations

HUMAN IMMUNE RESPONSE TO CARCINOEMBRYONIC ANTIGEN TUMOR VACCINES

1995 • 15 citations

Differential signaling and hierarchical response thresholds induced by an immunodominant peptide of myelin basic protein and an altered peptide ligand in human T cells

1998 • 10 citations

Recombinant Carcinoembryonic Antigen and Granulocyte-Macrophage Colony-Stimulating Factor for Active Immunization of Colorectal Carcinoma Patients

1996 • 6 citations

POST TRANSPLANT IMMUNOTHERAPY IN METASTATIC BREAST CANCER (MBC)

1996 • 5 citations