Exploring immunological specificity using synthetic peptide combinatorial libraries

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

1991 • 1,319 citations

A very high level of crossreactivity is an essential feature of the T-cell receptor

1998 • 930 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

The Three-Dimensional Structure of Peptide-MHC Complexes

1995 • 817 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

A priori delineation of a peptide which mimics a discontinuous antigenic determinant

1986 • 499 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids

1998 • 438 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

MHC Ligands and Peptide Motifs

1997 • 336 citations

Essential flexibility in the T-cell recognition of antigen

1996 • 330 citations

Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

1992 • 326 citations

Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone

1997 • 320 citations

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.

1993 • 238 citations

Simultaneous multiple peptide synthesis under continuous flow conditions on cellulose paper discs as segmental solid supports

1988 • 218 citations

Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.

1996 • 205 citations

Molecular Basis for the Binding Promiscuity of an Anti-p24 (HIV-1) Monoclonal Antibody

1997 • 197 citations

Relationships Among TCR Ligand Potency, Thresholds for Effector Function Elicitation, and the Quality of Early Signaling Events in Human T Cells

1998 • 157 citations

Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.

1998 • 156 citations

Probing degeneracy in T-cell recognition using peptide combinatorial libraries

1998 • 137 citations

Phage-displayed peptide libraries

1998 • 123 citations

Cutting Edge: Predictable TCR Antigen Recognition Based on Peptide Scans Leads to the Identification of Agonist Ligands with No Sequence Homology

1998 • 118 citations

Crystallographic Analysis of Anti-p24 (HIV-1) Monoclonal Antibody Cross-Reactivity and Polyspecificity

1997 • 118 citations

The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides.

1992 • 115 citations

A Basis for Alloreactivity: MHC Helical Residues Broaden Peptide Recognition by the TCR

1998 • 110 citations

The identification of CD4 ⁺ T cell epitopes with dedicated synthetic peptide libraries

1997 • 99 citations

Peptide binding specificity of major histocompatibility complex class I resolved into an array of apparently independent subspecificities: quantitation by peptide libraries and improved prediction of binding

1996 • 99 citations

Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic decapeptide library composed of four trillion (4 × 1012) sequences

1994 • 93 citations

New Ligands Binding to the Human Leukocyte Antigen Class II Molecule DRB1^*0101 Based on the Activity Pattern of an Undecapeptide Library

1996 • 74 citations

Versatility of positional scanning synthetic combinatorial libraries for the identification of individual compounds

1994 • 67 citations

Tolerance to Amino Acid Variations in Peptides Binding to the Major Histocompatibility Complex Class I Protein H-2Kb

1995 • 62 citations

A Peptide Mimic of a Protective Epitope of Respiratory Syncytial Virus Selected from a Combinatorial Library Induces Virus-Neutralizing Antibodies and Reduces Viral Load In Vivo

1998 • 61 citations

Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes.

1996 • 59 citations

Screening chemically synthesized peptide libraries for biologically-relevant molecules

1993 • 58 citations

Determination of T cell epitopes with random peptide libraries

1996 • 58 citations

Specificity and degeneracy of minor histocompatibility antigen-specific MHC-restricted CTL.

1996 • 55 citations

HLA Class I Binding Motifs Derived from Random Peptide Libraries Differ at the COOH Terminus from Those of Eluted Peptides

1997 • 50 citations

Alloreactivity as a Source of High Avidity Peptide-Specific Human CTL

1999 • 45 citations

Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries.

1998 • 44 citations

The use of dedicated peptide libraries permits the discovery of high affinity binding peptides

1995 • 42 citations

T-cell epitope determination

1996 • 40 citations

Efficient Generation of Major Histocompatibility Complex Class I-Peptide Complexes Using Synthetic Peptide Libraries

1998 • 39 citations

Definition of Natural T Cell Antigens with Mimicry Epitopes Obtained from Dedicated Synthetic Peptide Libraries

1998 • 38 citations

Synthetic peptide combinatorial libraries (SPCLs): identification of the antigenic determinant of β-endorphin recognized by monoclonal antibody 3E7

1993 • 37 citations

Discovery of d-amino-acid-containing ligands with selectide technology

1993 • 34 citations

A general route to fingerprint analyses of peptide-antibody interactions using a clustered amino acid peptide library: Comparison with a phage display library

1995 • 31 citations

The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells

1998 • 27 citations

Peptide sequences binding to MHC class I proteins

1994 • 25 citations

Identification of related peptides recognized by a monoclonal antibody using a synthetic peptide combinatorial library

1992 • 25 citations

All-d peptides recognized by an anti-carbohydrate antibody identified from a positional scanning library

1998 • 24 citations

Identification of the Peptides That Inhibit the Stimulation of Thyrotropin Receptor by Graves’ Immunoglobulin G from Peptide Libraries¹

1997 • 24 citations

Mapping the detailed specificity of a calcium-dependent monoclonal antibody through the use of soluble positional scanning combinatorial libraries: Identification of potent calcium-independent antigens

1995 • 21 citations

Exploring antibody polyspecificity using synthetic combinatorial libraries

1996 • 18 citations

Idiotype specific peptides bind to the surface immunoglobulins of two murine B-cell lymphoma lines, inducing signal transduction.

1995 • 16 citations

Amino Acid Preferences in the Octapeptide Subunit of the Major Histocompatibility Complex Class I Heterotrimer H‐2L^d

1996 • 16 citations

Elucidation of monoclonal antibody polyspecificity using a synthetic combinatorial library.

1995 • 14 citations

Elucidation of the Core Residues of an Epitope Using Membrane-based Combinatorial Peptide Libraries

1996 • 13 citations

Identification of the Peptides That Inhibit the Stimulation of Thyrotropin Receptor by Graves' Immunoglobulin G from Peptide Libraries

1997 • 13 citations

Highly specific, cross-reactive sequences recognized by an anti-HBsAg antibody identified from a positional scanning synthetic combinatorial library.

1996 • 12 citations

Combinatorial search for diagnostic agents: Lyme antibody H9724 as an example

1998 • 7 citations

Characterization of antigen-antibody interactions using single substitution analogs and mixture-based synthetic combinatorial libraries

1998 • 6 citations

Two antipeptide monoclonal antibodies that recognize adhesive sequences in fibrinogen: identification of antigenic determinants and unrelated sequences using synthetic combinatorial libraries.

1995 • 4 citations

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