Sequence-dependent modulation of nucleotide excision repair: the efficiency of the incision reaction is inversely correlated with the stability of the pre-incision UvrB-DNA complex

DNA REPAIR ENZYMES

1988 • 822 citations

A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region

1983 • 618 citations

Nucleotide excision repair in Escherichia coli

1990 • 420 citations

Slow Repair of Pyrimidine Dimers at p53 Mutation Hotspots in Skin Cancer

1994 • 301 citations

The (A)BC excinuclease of Escherichia coli has only the UvrB and UvrC subunits in the incision complex.

1989 • 204 citations

Physical studies on deoxyribonucleic acid after covalent binding of a carcinogen

1972 • 187 citations

Single adduct mutagenesis: strong effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.

1989 • 141 citations

Amplification and purification of UvrA, UvrB, and UvrC proteins of Escherichia coli.

1985 • 124 citations

Active site of (A)BC excinuclease. I. Evidence for 5' incision by UvrC through a catalytic site involving Asp399, Asp438, Asp466, and His538 residues.

1992 • 123 citations

Comparative orientation of the fluorene residue in native DNA modified by N-acetoxy-N-2-acetylaminofluorene and two 7-halogeno derivatives

1976 • 123 citations

In vitro recognition of carcinogen-induced local denaturation sites in native DNA by S1 endonuclease from Aspergillus oryzae

1975 • 119 citations

Formation and enzymatic properties of the UvrB.DNA complex.

1990 • 119 citations

Helicase properties of the Escherichia coli UvrAB protein complex.

1987 • 113 citations

Structural characterization of an N-acetyl-2-aminofluorene (AAF) modified DNA oligomer by NMR, energy minimization, and molecular dynamics

1993 • 112 citations

Active site of (A)BC excinuclease. II. Binding, bending, and catalysis mutants of UvrB reveal a direct role in 3‘ and an indirect role in 5‘ incision.

1992 • 102 citations

Characterization of the Helicase Activity of the Escherichia coli UvrAB Protein Complex

1989 • 101 citations

(A)BC excinuclease: the Escherichia coli nucleotide excision repair enzyme

1992 • 94 citations

The C-terminal Region of the UvrB Protein of Escherichia coli Contains an Important Determinant for UvrC Binding to the Preincision Complex but Not the Catalytic Site for 3′-Incision

1995 • 83 citations

Analysis of UvrABC endonuclease reaction intermediates on cisplatin-damaged DNA using mobility shift gel electrophoresis.

1992 • 77 citations

ATPase activity of the UvrA and UvrAB protein complexes of theEscherichia coliUvrABC endonuclease

1989 • 75 citations

Construction of plasmids containing a unique acetylaminofluorene adduct located within a mutation hot spot

1989 • 74 citations

Helicase Motifs V and VI of the Escherichia coli UvrB Protein of the UvrABC Endonuclease Are Essential for the Formation of the Preincision Complex

1994 • 72 citations

Acetylaminofluorene bound to different guanines of the sequence -GGCGCC- is excised with different efficiencies by the UvrABC excision nuclease in a pattern not correlated to the potency of mutation induction.

1990 • 70 citations

Identification of the different intermediates in the interaction of (A)BC excinuclease with its substrates by DNase I footprinting on two uniquely modified oligonucleotides

1991 • 66 citations

The effect ofEscherichia coliUvr protein binding on the topology of supercoiled DNA

1986 • 65 citations

Strong sequence-dependent polymorphism in adduct-induced DNA structure: analysis of single N-2-acetylaminofluorene residues bound within the NarI mutation hot spot

1991 • 59 citations

Comparative studies on the 7-iodo and 7-fluoro derivatives of N-acetoxy-N-2-acetylaminofluorene: binding sites on DNA and conformational change of modified deoxytrinucleotides

1978 • 56 citations

Polymorphism in N-2-acetylaminoflurene induced Dna Struture as reveled by Dnase I footprinting

1991 • 27 citations

Binding and Incision Activities of UvrABC Excinuclease on Slipped DNA Intermediates that Generate Frameshift Mutations

1996 • 12 citations

Flow Linear Dichroism and Electron Microscopic Analysis of Protein-DNA Complexes of a Mutant UvrB Protein that Binds to but cannot Kink DNA

1994 • 8 citations