Structural characterization of an N-acetyl-2-aminofluorene (AAF) modified DNA oligomer by NMR, energy minimization, and molecular dynamics

Comparison of simple potential functions for simulating liquid water

1983 • 37,746 citations

A new force field for molecular mechanical simulation of nucleic acids and proteins

1984 • 4,553 citations

An all atom force field for simulations of proteins and nucleic acids

1986 • 3,388 citations

An approach to computing electrostatic charges for molecules

1984 • 3,231 citations

Molecular structure of a left-handed double helical DNA fragment at atomic resolution

1979 • 2,057 citations

Algorithms for macromolecular dynamics and constraint dynamics

1977 • 1,704 citations

Nucleic acids and nuclear magnetic resonance

1988 • 269 citations

Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons

1990 • 239 citations

Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA.

1992 • 228 citations

Physical studies on deoxyribonucleic acid after covalent binding of a carcinogen

1972 • 187 citations

Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents

1988 • 177 citations

DNA binding and mutation spectra of the carcinogen N-2-aminofluorene in Escherichia coli

1985 • 146 citations

Induction of the Z conformation in poly(dG-dC).poly(dG-dC) by binding of N-2-acetylaminofluorene to guanine residues.

1981 • 143 citations

Single adduct mutagenesis: strong effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.

1989 • 141 citations

On the mechanism of action of carcinogenic aromatic amines

1969 • 138 citations

Conformation of poly(dG-dC) . poly(dG-dC) modified by the carcinogens N-acetoxy-N-acetyl-2-aminofluorene and N-hydroxy-N-2-aminofluorene.

1980 • 129 citations

NMR and computational characterization of the N-(deoxyguanosin-8-yl)aminofluorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[syn].cntdot.A[anti] pair formation and its pH dependence

1989 • 118 citations

Carcinogen-induced frameshift mutagenesis in repetitive sequences.

1992 • 107 citations

Sequential assignments for the hydrogen and phosphorus-31 atoms in the backbone of oligonucleotides by two-dimensional nuclear magnetic resonance

1983 • 99 citations

Sensitivity of the conformation of deoxyguanosine to bind ing at the C-8 position by N-acetylated and unacetylated 2-aminofluorene

1980 • 89 citations

Modification of ribonucleic acid by chemical carcinogens IV. Circular dichroism and proton magnetic resonance studies of oligonucleotides modified with N-2-acetylaminofluorene

1971 • 88 citations

Deoxyribose conformation in [d(GTATATAC)]2: evaluation of sugar pucker by simulation of double-quantum-filtered COSY cross-peaks

1990 • 68 citations

Conformation of the deoxydinucleoside monophosphate dCpdG modified at carbon 8 of guanine with 2-(acetylamino)fluorene

1982 • 66 citations

Three-dimensional structure of the wild-type lac pribnow promoter DNA in solution

1988 • 63 citations

Prediction of DNA structure from sequence: A build‐up technique

1989 • 62 citations

Coding and Conformational Properties of Oligonucleotides Modified with the Carcinogen N -2-Acetylaminofluorene

1970 • 62 citations

NMR structural studies of a 15-mer DNA sequence from a ras protooncogene, modified at the first base of codon 61 with the carcinogen 4-aminobiphenyl

1992 • 60 citations

Strong sequence-dependent polymorphism in adduct-induced DNA structure: analysis of single N-2-acetylaminofluorene residues bound within the NarI mutation hot spot

1991 • 59 citations

Toward a Dynamical Structure of DNA: Comparison of Theoretical and Experimental NOE Intensities

1992 • 56 citations

Z-DNA conformation of N-2-acetylaminofluorene modified poly(dG-dC)·poly(dG-dC) determined by reactivity with anti cytidine antibodies and minimized potential energy calculations

1981 • 55 citations

Conformation of acetylaminofluorene and aminofluorene modified guanosine and guanosine derivatives

1980 • 51 citations

Molecular recognition in noncovalent antitumor agent-DNA complexes: NMR studies of the base and sequence dependent recognition of the DNA minor groove by netropsin

1985 • 46 citations

Strong structural effect of the position of a single acetylaminofluorene adduct within a mutation hot spot

1989 • 44 citations

Proton nuclear magnetic resonance study of a self-complementary decadeoxyribonucleotide, C-C-A-A-G-C-T-T-G-G

1982 • 43 citations

Theoretical studies of nucleic acid interactions. I. Estimates of conformational mobility in intercalated chains

1983 • 38 citations

Changes of stability and conformation of DNA following the covalent binding of a carcinogen

1971 • 38 citations

Minor-Groove Binding Models for Acetylaminofluorene Modified DNA

1989 • 37 citations

Deoxyribose ring conformation of [d(GGTATACC)]2: an analysis of vicinal proton-proton coupling constants from two-dimensional proton nuclear magnetic resonance

1988 • 35 citations

Force field conformational analysis of aminofluorene and acetylaminofluorene substituted deoxyguanosine

1982 • 33 citations

Two-dimensional NMR studies on the anthramycin-d(ATGCAT)2 adduct

1989 • 31 citations

NMR structural refinement of a tandem G.cntdot.A mismatched decamer d(CCAAGATTGG)2 via the hybrid matrix procedure

1991 • 29 citations

The DNA bending by acetylaminofluorene residues and by apurinic sites

1989 • 27 citations

Polymorphism in N-2-acetylaminoflurene induced Dna Struture as reveled by Dnase I footprinting

1991 • 27 citations

Influence of the carcinogen 4-aminobiphenyl on DNA conformation

1985 • 24 citations

DNA bending induced by covalently bound drugs

1990 • 24 citations

Large-scale purification of synthetic oligonucleotides and carcinogen-modified oligodeoxynucleotides on a reverse-phase polystyrene (PRP-1) column

1990 • 23 citations

Two-Dimensional¹H and³¹P NMR Spectra of a Decamer Oligodeoxyribonucleotide Duplex and a Quinoxaline ([MeCys³, MeCys⁷]TANDEM) Drug Duplex Complex

1989 • 21 citations

Minimization and molecular dynamics studies of guanosine and Z‐DNA modified by N‐2‐acetylaminofluorene

1991 • 18 citations

Synthesis, modification with N-acetoxy-2-acetylaminofluorene and physicochemical studies of DNA model compound d(TACGTA)

1985 • 15 citations

Visualization of an AAF induced frameshift mutation: molecular views of base displacement in B-DNA from minimized potential energy calculations

1987 • 14 citations

N-acetoxy-2-acetylaminofluorene modification of a deoxyoligonucleotide duplex

1985 • 13 citations

NMR study of stacking interactions and conformational adjustments in the dinucleotide-carcinogen adduct 2'-deoxycytidylyl-(3 .fwdarw. 5)-2'-deoxy-8-(N-fluoren-2-ylacetamido)guanosine

1988 • 10 citations

Conformational analysis of the 2′‐deoxyribofuranose ring from proton–proton coupling constants: Analysis of a nucleoside‐carcinogen adduct formed from 2‐acetylaminofluorene utilizing a three‐state model

1987 • 6 citations