Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Nitric Oxide Synthases: Properties and Catalytic Mechanism

1995 • 1,275 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer.

1987 • 881 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

1993 • 671 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

BIOSYNTHESIS AND METABOLISM OF TETRAHYDROBIOPTERIN AND MOLYBDOPTERIN

1985 • 542 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Partial Purification and Characterization of Tryptophan Hydroxylase from Rabbit Hindbrain

1972 • 445 citations

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

1992 • 444 citations

Purification of a Ca²⁺/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

1990 • 433 citations

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

1991 • 422 citations

Solubilization and Partial Purification of Tyrosine Hydroxylase from Bovine Adrenal Medulla

1971 • 412 citations

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.

1993 • 391 citations

THE STRUCTURE OF THE PHENYLALANINE-HYDROXYLATION COFACTOR

1963 • 378 citations

Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

1990 • 288 citations

Peroxynitrite-induced rat colitis—A new model of colonic inflammation

1993 • 264 citations

Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer.

1994 • 247 citations

Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present.

1990 • 239 citations

The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.

1994 • 218 citations

Further Studies on the Phenylalanine-hydroxylation Cofactor

1959 • 180 citations

Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity

1992 • 174 citations

Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.

1991 • 164 citations

Calcium/calmodulin-dependent nitric oxide synthase type I: a biopteroflavoprotein with calcium/calmodulin-independent diaphorase and reductase activities

1992 • 151 citations

Tetrahydrobiopterin and Cytokines

1993 • 108 citations

Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species

1984 • 105 citations

Regulation of the L‐arginine‐dependent and tetrahydrobiopterin‐dependent biosynthesis of nitric oxide in murine macrophages

1993 • 76 citations

Tetrahydrobiopterin-deficient nitric oxide synthase has a modified heme environment and forms a cytochrome P 420 analog

1995 • 65 citations

Inhibition of Nitric Oxide Synthesis Enhances the Expression of Inducible Nitric Oxide Synthase mRNA and Protein in a Model of Chronic Liver Inflammation

1994 • 53 citations

High-performance liquid chromatographic analysis of the unusual pathway of oxidation of l-arginine to citrulline and nitric oxide in mammalian cells

1991 • 32 citations

Mammalian brain dihydrofolate reductase¹

1977 • 8 citations