Telomeres and telomerases

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Structure and function of telomeres

1991 • 3,524 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Monovalent cation-induced structure of telomeric DNA: The G-quartet model

1989 • 1,202 citations

Inhibition of telomerase by G-quartet DMA structures

1991 • 1,086 citations

Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops

1989 • 939 citations

An alternative pathway for yeast telomere maintenance rescues est1− senescence

1993 • 916 citations

A mutant with a defect in telomere elongation leads to senescence in yeast

1989 • 905 citations

Crystal structure of four-stranded Oxytricha telomeric DNA

1992 • 556 citations

TELOMERASES

1992 • 531 citations

Quadruplex structure of Oxytricha telomeric DNA oligonucleotides

1992 • 520 citations

The telomere hypothesis of cellular aging

1992 • 492 citations

A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.

1992 • 480 citations

All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus.

1981 • 477 citations

Saccharomyces telomeres acquire single-strand TG1–3 tails late in S phase

1993 • 407 citations

Hairpin and parallel quartet structures for telomeric sequences

1992 • 390 citations

Human telomeres are attached to the nuclear matrix.

1992 • 334 citations

Silencers, silencing, and heritable transcriptional states

1992 • 296 citations

An overhanging 3' terminus is a conserved feature of telomeres.

1989 • 286 citations

A mammalian factor that binds telomeric TTAGGG repeats in vitro.

1992 • 250 citations

Telomere positional effects and the regulation of cellular senescence

1992 • 246 citations

Telomerase is processive.

1991 • 238 citations

C-Terminal Truncation of RAP1 Results in the Deregulation of Telomere Size, Stability, and Function in Saccharomyces cerevisiae

1992 • 233 citations

Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.

1991 • 218 citations

Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices.

1993 • 216 citations

Developmentally programmed healing of chromosomes by telomerase in tetrahymena

1991 • 204 citations

Identification of a Pentanucleotide Telomeric Sequence, (TTAGG)_n, in the Silkworm Bombyx mori and in Other Insects

1993 • 183 citations

HeT-A, a transposable element specifically involved in "healing" broken chromosome ends in Drosophila melanogaster.

1992 • 180 citations

NMR study of parallel-stranded tetraplex formation by the hexadeoxynucleotide d(TG4T)

1992 • 175 citations

The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae.

1992 • 171 citations

Identification of a pentanucleotide telomeric sequence, (TTAGG)n, in the silkworm Bombyx mori and in other insects.

1993 • 164 citations

Identification of a nonprocessive telomerase activity from mouse cells.

1993 • 164 citations

Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation.

1993 • 157 citations

Thermodynamics of G-tetraplex formation by telomeric DNAs

1993 • 152 citations

Frequent transpositions of Drosophila melanogaster HeT-A transposable elements to receding chromosome ends.

1992 • 144 citations

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.

1992 • 141 citations

Telomeres and the functional architecture of the nucleus

1993 • 132 citations

New telomere formation after developmentally regulated chromosomal breakage during the process of chromatin diminution in ascaris lumbricoides

1991 • 130 citations

Dynamics of telomere length variation in tetrahymena thermophila

1987 • 130 citations

Genetics and Molecular Biology of Telomeres

1992 • 128 citations

Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein

1990 • 113 citations

Telomere structure in Euplotes crassus: characterization of DNA-protein interactions and isolation of a telomere-binding protein.

1990 • 108 citations

Unusually large telomeric repeats in the yeast Candida albicans.

1993 • 94 citations

Position effect and related phenomena

1992 • 91 citations

A spontaneously opened ring chromosome of Drosophila melanogaster has acquired He-T DNA sequences at both new telomeres.

1988 • 90 citations

Differential size variations between transcriptionally active and inactive telomeres ofTrypanosoma brucei

1983 • 84 citations

Telomeric structure in cells with chromosome end associations

1993 • 78 citations

Silencers, silencing, and heritable transcriptional states.

1992 • 78 citations

Dissection of a Carboxy-Terminal Region of the Yeast Regulatory Protein RAP1 with Effects on Both Transcriptional Activation and Silencing

1992 • 76 citations

RNA Polymerase Marching Backward

1993 • 74 citations

A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins.

1993 • 72 citations

Effect of thymine tract length on the structure and stability of model telomeric sequences

1993 • 67 citations

Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit.

1993 • 66 citations

Euplotes crassushas genes encoding telomere-binding proteins and telomere-binding protein homologs

1992 • 65 citations

Dissection of a carboxy-terminal region of the yeast regulatory protein RAP1 with effects on both transcriptional activation and silencing.

1992 • 46 citations

Nucleic acid specificity of a vertebrate telomere-binding protein: evidence for G-G base pair recognition at the core-binding site.

1992 • 44 citations

A repetitive DNA element, associated with telomeric sequences in Drosophila melanogaster, contains open reading frames

1992 • 42 citations

DNA recognition and binding by the Euplotes telomere protein

1992 • 39 citations

Characterization of a Telomere-Binding Protein from Physarum polycephalum

1991 • 38 citations

Complex Telomere-Associated Repeat Units in Members of the Genus Chironomus Evolve from Sequences Similar to Simple Telomeric Repeats

1993 • 35 citations

Complex telomere-associated repeat units in members of the genus Chironomus evolve from sequences similar to simple telomeric repeats.

1993 • 34 citations

Centromeres and telomeres

1992 • 33 citations

Hoogsteen G-G base pairing is dispensable for telomere healing in yeast

1992 • 31 citations

Characterization of a telomere-binding protein from Physarum polycephalum.

1991 • 21 citations

Drosophila melanogaster does not share the telomeric repeat sequence of another invertebrate, Ascaris lumbricoides

1993 • 21 citations

Purification of a telomere-binding protein from Physarum polycephalum

1992 • 7 citations