A potent new mode of β-lactamase inhibition revealed by the 1.7 Å X-ray crystallographic structure of the TEM-1–BLIP complex

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

The Crisis in Antibiotic Resistance

1992 • 2,815 citations

[1] Production of single-stranded plasmid DNA

1987 • 2,642 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Crystal structure of a yeast TBP/TATA-box complex

1993 • 1,082 citations

Co-crystal structure of TBP recognizing the minor groove of a TATA element

1993 • 1,039 citations

Crystal structure of trp represser/operator complex at atomic resolution

1988 • 899 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

A structural basis of the interactions between leucine-rich repeats and protein ligands

1995 • 726 citations

Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus

1977 • 695 citations

Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution

1992 • 515 citations

Protein-protein recognition: Crystal structural analysis of a barnase-barstar complex at 2.0-.ANG. resolution

1994 • 359 citations

Penicillin resistance: the chemistry of .beta.-lactamase inhibition

1985 • 223 citations

Refined crystal structure of β-lactamase from Staphylococcus aureus PC1 at 2.0 Å resolution

1991 • 217 citations

Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli

1993 • 158 citations

Conjugate-direction minimization: an improved method for the refinement of macromolecules

1992 • 148 citations

Elusive affinities

1995 • 145 citations

Beta-lactamases as fully efficient enzymes. Determination of all the rate constants in the acyl-enzyme mechanism.

1990 • 141 citations

Site-directed mutants, at position 166, of RTEM-1 beta-lactamase that form a stable acyl-enzyme intermediate with penicillin.

1991 • 137 citations

Structural and kinetic characterization of a β-lactamase-inhibitor protein

1994 • 117 citations

Isolation and characterization of a beta-lactamase-inhibitory protein from Streptomyces clavuligerus and cloning and analysis of the corresponding gene

1990 • 108 citations

Recognition between a bacterial ribonuclease, barnase, and its natural inhibitor, barstar

1993 • 106 citations

On the fast rotation function

1987 • 79 citations

Site-directed mutagenesis of .beta.-lactamase leading to accumulation of a catalytic intermediate

1991 • 74 citations

Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex.

1994 • 68 citations

Crystal Structure of DCoH, a Bifunctional, Protein-Binding Transcriptional Coactivator

1995 • 58 citations

Proteinase-protein inhibitor interaction.

1991 • 29 citations

Design of a small peptide-based proteinase inhibitor by modeling the active-site region of barley chymotrypsin inhibitor 2

1991 • 20 citations