Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex.

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Assessment of protein models with three-dimensional profiles

1992 • 3,317 citations

A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

1991 • 2,629 citations

Protein Inhibitors of Proteinases

1980 • 2,220 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Tertiary templates for proteins

1987 • 1,485 citations

Hydrogen bonding and biological specificity analysed by protein engineering

1985 • 1,050 citations

Natural protein proteinase inhibitors and their interaction with proteinases

1992 • 1,048 citations

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.

1989 • 889 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin

1990 • 718 citations

Three-dimensional structure of an antibody-antigen complex.

1987 • 615 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1974 • 548 citations

The refined crystal structure of bovine β-trypsin at 1·8 Å resolution

1975 • 462 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1973 • 449 citations

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

1974 • 431 citations

Tick Anticoagulant Peptide (TAP) Is a Novel Inhibitor of Blood Coagulation Factor Xa

1990 • 414 citations

Hydrogen bonds involving sulfur atoms in proteins

1991 • 240 citations

Crystal and molecular structures of the complex of α-chymotrypsin with its inhibitor Turkey ovomucoid third domain at 1.8 Å resolution

1987 • 215 citations

The Three-Dimensional Structure of Asn ¹⁰² Mutant of Trypsin: Role of Asp ¹⁰² in Serine Protease Catalysis

1987 • 212 citations

Structure of native porcine pancreatic elastase at 1.65 Å resolution

1988 • 155 citations

Purification from Escherichia coli of a periplasmic protein that is a potent inhibitor of pancreatic proteases.

1983 • 127 citations

The refinement and the structure of the dimer of alpha-chymotrypsin at 1.67-A resolution.

1985 • 121 citations

The crystal and molecular structure of the third domain of silver pheasant ovomucoid (OMSVP3)

1985 • 119 citations

Stability and specificity of protein-protein interactions: The case of the trypsin-trypsin inhibitor complexes

1976 • 113 citations

Refined crystal structure of the complex of subtilisin BPN′ and Streptomyces subtilisin inhibitor at 1·8Åresolution

1991 • 102 citations

Relocating a Negative Charge in the Binding Pocket of Trypsin

1993 • 68 citations

-Chymotrypsin: What Can We Learn about Catalysis from X-Ray Diffraction?

1972 • 61 citations

The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli.

1991 • 57 citations

PRISM: topologically constrained phased refinement for macromolecular crystallography

1993 • 28 citations

Solvent accessibility properties of complex proteins

1979 • 27 citations

Expression of the protease inhibitor ecotin and its co-crystallization with trypsin

1991 • 27 citations

PRISM: application to the solution of two protein structures

1993 • 7 citations