Tachykinins: receptor to effector

Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.

1991 • 1,760 citations

Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides

1988 • 1,673 citations

An unidentified depressor substance in certain tissue extracts

1931 • 1,565 citations

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

1978 • 1,426 citations

Neurotransmitter functions of mammalian tachykinins.

1993 • 1,101 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

The sensory-efferent function of capsaicin-sensitive sensory neurons

1988 • 935 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Amino-acid Sequence of Substance P

1971 • 769 citations

Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor

1983 • 751 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology.

1993 • 734 citations

Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.

1987 • 651 citations

Tachykinin receptors and tachykinin receptor antagonists

1993 • 649 citations

Receptors and antagonists for substance P and related peptides.

1994 • 622 citations

Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing

1984 • 563 citations

The tachykinin peptide family

1981 • 470 citations

Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase

1984 • 451 citations

A potent and selective non-peptide antagonist of the neurokinin a (NK2) receptor

1992 • 441 citations

Molecular chaperones in protein folding: the art of avoiding sticky situations

1994 • 402 citations

New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization

1988 • 360 citations

Molecular Characterization of a Functional cDNA Encoding the Rat Substance P Receptor

1990 • 355 citations

The effects of substance P on histamine and 5‐hydroxytryptamine release in the rat

1982 • 347 citations

Pharmacological receptors for substance P and neurokinins

1987 • 337 citations

Three-dimensional models of neurotransmitter G-binding protein-coupled receptors.

1991 • 330 citations

Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues

1989 • 329 citations

Cloning and expression of a rat neuromedin K receptor cDNA.

1990 • 308 citations

Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig

1985 • 280 citations

Neuropeptide K: Isolation, structure and biological activities of a novel brain tachykinin

1985 • 279 citations

A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation

1981 • 266 citations

Neutral metalloendopeptidase in human lung tissue and cultured cells.

1985 • 259 citations

Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics

1991 • 252 citations

Substance P precursor and kininogen: their structures, gene organizations, and regulation

1987 • 241 citations

Structure and gene organization of bovine neuromedin K precursor.

1986 • 230 citations

Substance P raises neuronal membrane excitability by reducing inward rectification

1985 • 230 citations

Polypeptide-Containing Neurons in Airway Smooth Muscle

1987 • 227 citations

Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma

1990 • 227 citations

Investigation into species variants in tachykinin NK₁ receptors by use of the non‐peptide antagonist, CP‐96,345

1991 • 224 citations

SR 142801, The first potent non-peptide antagonist of the tachykinin NK3 receptor

1994 • 222 citations

Discovery of a potent substance P antagonist: recognition of the key molecular determinant

1992 • 220 citations

Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor.

1993 • 215 citations

Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist

1993 • 213 citations

Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides

1977 • 193 citations

Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor.

1992 • 190 citations

Biological evaluation of substance P antagonists

1984 • 189 citations

NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin- induced nociception

1994 • 187 citations

Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist

1992 • 187 citations

Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.

1992 • 175 citations

Neurokinin A (NK2) receptor revisited with SR 48968, a potent non-peptide antagonist

1992 • 171 citations

Purification and Characterisation of a Membrane-Bound Substance-P-Degrading Enzyme from Human Brain

1981 • 170 citations

Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands.

1980 • 168 citations

Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS

1984 • 164 citations

Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids

1993 • 162 citations

Neuropeptide‐γ: A Peptide Isolated from Rabbit Intestine that Is Derived from γ‐Preprotachykinin

1988 • 160 citations

The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels

1992 • 160 citations

Characterization of the substance P receptor in rat brain cortex membranes and the inhibition of radioligand binding by guanine nucleotides.

1983 • 151 citations

Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects.

1995 • 142 citations

Substance P (NK1)- and neurokinin A (NK2)-receptor gene expression in inflammatory airway diseases

1995 • 140 citations

Eosinophils within the healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide

1994 • 137 citations

An immunohistochemical study of endopeptidase-24.11 (“enkephalinase”) in the pig nervous system

1986 • 129 citations

Cleavage of substance P to an N-terminal tetrapeptide and a C-terminal heptapeptide by a post-proline cleaving enzyme from bovine brain

1980 • 127 citations

Effects of tachykinins on mucus secretion in human bronchi in vitro

1989 • 123 citations

Organization, structure, and expression of the gene encoding the rat substance P receptor

1991 • 123 citations

A Substance P Antagonist, [D-Pro ² , D-Trp ^7,9 ]SP, Inhibits Inflammatory Responses in the Rabbit Eye

1981 • 122 citations

Depressor substances in extracts of intestine

1934 • 122 citations

Determination of the amino acid residues in substance P conferring selectivity and specificity for the rat neurokinin receptors.

1992 • 121 citations

Molecular basis for the species selectivity of the substance P antagonist CP-96,345.

1993 • 118 citations

3h-substance P binding to salivary gland membranes. Regulation by guanyl nucleotides and divalent cations.

1983 • 116 citations

STIMULATORY EFFECTS OF SUBSTANCE P ON NEURITE EXTENSION AND CYCLIC AMP LEVELS IN CULTURED NEUROBLASTOMA CELLS

1978 • 115 citations

A cDNA encoding the precursor of the rat neuropeptide, neurokinin B

1987 • 112 citations

Molecular aspects of the tachykinin receptors

1993 • 109 citations

Visualization of neurokinin-3 receptor sites in rat brain using the highly selective ligand [3H]senktide

1990 • 105 citations

Multiple tachykinins are produced and secreted upon post-translational processing of the three substance P precursor proteins, α-, β-, and γ-preprotachykinin

1989 • 100 citations

Quantitative autoradiographic analysis of the distribution of binding sites for [125I]Bolton Hunter derivatives of eledoisin and substance P in the rat brain

1986 • 100 citations

Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease

1988 • 100 citations

Analgesic effect of antagonists of substance P

1981 • 99 citations

Chimeric NK1 (substance P)/NK3 (neurokinin B) receptors. Identification of domains determining the binding specificity of tachykinin agonists.

1993 • 99 citations

Neuropeptide content of lungs from asthmatic and nonasthmatic patients.

1995 • 97 citations

Roles of neutral endopeptidase in airways

1991 • 96 citations

Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects.

1995 • 93 citations

Characterization of the effects produced by neurokinins and three agonists selective for neurokinin receptor subtypes in a spinal nociceptive reflex of the rat

1988 • 92 citations

Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea.

1993 • 91 citations

Antinociceptive and neurotoxic actions of substance P analogues in the rat's spinal cord after intrathecal administration

1985 • 90 citations

The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels

1992 • 88 citations

Low plasma concentrations of VIP and elevated levels of other neuropeptides during exacerbations of asthma

1994 • 83 citations

Differential processing of substance P and neurokinin A by plasma dipeptidyl(amino)peptidase IV, aminopeptidase M and angiotensin converting enzyme

1991 • 82 citations

The pharmacology of GR203040, a novel, potent and selective non‐peptide tachykinin NK₁ receptor antagonist

1995 • 80 citations

Dissociated cell culture of cholinergic neurons from nucleus basalis of Meynert and other basal forebrain nuclei.

1985 • 80 citations

Neurotropic Effects of Substance P

1956 • 79 citations

Further evidence for the existence of NK₂ tachykinin receptor subtypes

1991 • 77 citations

Binding characteristics of [125I]Bolton-Hunter [Sar9, Met(O2)11]substance P, a new selective radioligand for the NK1 receptor

1990 • 73 citations

Enhanced in vivo release of substance P in the nucleus tractus solitarii during hypoxia in the rabbit: role of peripheral input

1991 • 73 citations

Pharmacological characterization of four related substance P antagonist

1982 • 71 citations

MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors.

1994 • 71 citations

Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.

1993 • 69 citations

The rising sun shines on substance P and related peptides

1993 • 66 citations

Origin and colocalization of CGRP- and SP-reactive nerves in cat airway epithelium

1990 • 65 citations

Concentration of substance P‐like immunoreactivity (SPLI) in tissues of dog, rat and mouse¹

1981 • 65 citations

Tachykinin-induced phosphoinositide breakdown in airway smooth muscle and epithelium: relationship to contraction.

1988 • 62 citations

Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats

1989 • 61 citations

Release of substance P in the nucleus tractus solitarius measured by in vivo microdialysis: response to stimulation of the aortic depressor nerves in rabbit

1988 • 60 citations

Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea‐pigs in vivo

1993 • 60 citations

Cigarette smoke-induced airway oedema is blocked by the NK1 antagonist, CP-96,345

1991 • 60 citations

CHEMICAL AND PHARMACOLOGICAL PROPERTIES OF THE POTENT, SLOW CONTRACTING SUBSTANCE (KININ) IN WASP VENOM

1954 • 60 citations

The antagonism of bombesin in the CNS by substance P analogues

1984 • 59 citations

The metabolism of neuropeptides. Endopeptidase-24.11 in human synaptic membrane preparations hydrolyses substance P

1985 • 57 citations

A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: a hypothesis.

1993 • 56 citations

Different tachykinin receptor subtypes are coupled to the phosphoinositide or cyclic AMP signal transduction pathways in rat submandibular cells

1988 • 51 citations

‘Sensory‐efferent’ neural control of mucus secretion: characterization using tachykinin receptor antagonists in ferret trachea in vitro

1994 • 49 citations

Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists.

1994 • 49 citations

The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.

1994 • 48 citations

Distribution and localization of neurokinin A-like immunoreactivity and neurokinin B-like immunoreactivity in rat peripheral tissue

1990 • 48 citations

Mammalian tachykinin-induced hydrolysis of inositol phospholipids in rat brain slices

1985 • 44 citations

Substance P and bombesin elevate cytosolic Ca2+ by different molecular mechanisms in a rat pancreatic acinar cell line.

1990 • 44 citations

Substance P-induced depolarization in sympathetic neurons: not simple K-inactivation

1981 • 43 citations

Activity of peptide and non-peptide antagonists at peripheral NK1 receptors

1992 • 43 citations

PHARMACOLOGY OF SUBSTANCE P

1963 • 42 citations

Light microscopic evidence for a substance P-containing innervation of the human nucleus basalis of Meynert

1987 • 41 citations

Receptors in Asthmatic Airways

1990 • 41 citations

Non‐specific actions of the non‐peptide tachykinin receptor antagonists, CP‐96, 345, RP 67580 and SR 48968, on neurotransmission

1994 • 40 citations

Characterization of the Binding Sites of [3H]SR 48968, a Potent Nonpeptide Radioligand Antagonist of the Neurokinin-2 Receptor

1993 • 36 citations

Localization of the ligand binding site of the neurokinin-1 receptor: interpretation of chimeric mutations and single-residue substitutions.

1994 • 36 citations

Substance P in the ventrolateral medulla oblongata regulates ventilatory responses

1990 • 36 citations

Tachykinin control of ferret airways: Mucus secretion, bronchoconstriction and receptor mapping

1993 • 35 citations

Receptors mediating the effects of substance P and neurokinin A on mucus secretion and smooth muscle tone of the ferret trachea: potentiation by an enkephalinase inhibitor

1989 • 34 citations

Conserved His^VI‐17 of the NK‐1 receptor is involved in binding of non‐peptide antagonists but not substance P

1993 • 34 citations

Signal transduction and ligand-binding domains of the tachykinin receptors

1993 • 33 citations

Mechanisms and modulation of airway plasma exudation after direct inhalation of cigarette smoke.

1995 • 32 citations

Substance P: Endothelial localization and pharmacology in the human ovarian vein

1995 • 32 citations

Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra.

1987 • 32 citations

Synaptic vesicles containing substance P purified by chromatography on controlled pore glass

1982 • 31 citations

Substance P and nasal secretion in dog, rat, and man.

1989 • 30 citations

Direct demonstration of interactions between substance P immunoreactive terminals and tyrosine hydroxylase immunoreactive neurons in the substantia nigra of the rat: An ultrastructural study

1988 • 29 citations

Effects of aerosolised substance P on lung resistance in guinea‐pigs: a comparison between inhibition of neutral endopeptidase and angiotensin‐converting enzyme

1990 • 28 citations

Inhibitors of Peptidases: How They Influence the Biological Activities of Substance P, Neurokinins, Bradykinin and Angiotensin in Guinea Pig, Hamster and Rat Urinary Bladders

1990 • 27 citations

Evidence for a common molecular mode of action for chemically distinct nonpeptide antagonists at the neurokinin-1 (substance P) receptor.

1994 • 26 citations

Untersuchung über die foiologische Wirkung der Sutostanz P

1942 • 26 citations

Involvement of tachykinin receptors (NK1 and NK2) in sodium metabisulfite-induced airway effects.

1994 • 25 citations

Inhibitors of Peptidases: How They Influence the Biological Activities of Substance P, Neurokinins, Kinins and Angiotensins in Isolated Vessels

1990 • 24 citations

GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors

1994 • 21 citations

Differences in the effects of NK₁‐receptor antagonists, (±)‐CP 96,345 and CP 99,994, on agonist‐induced responses in guinea‐pig trachea

1994 • 21 citations

Guanine nucleotides decrease the affinity of substance P binding to its receptor

1990 • 21 citations

Effects of substance P on thyroidal cyclic AMP levels and thyroid hormone release from canine thyroid slices

1983 • 21 citations

Effects of Intraventricular Administration of Substance P

1954 • 18 citations

Characterization of the interaction of diacylpiperazine antagonists with the human neurokinin-1 receptor: identification of a common binding site for structurally dissimilar antagonists.

1995 • 18 citations

Electron-immunocytochemistry of peptides in endothelial cells of rabbit cerebral vessels following perfusion with a perfluorocarbon emulsion

1993 • 17 citations

Radioiodinated l-703,606: A potent, selective antagonist to the human NK1 receptor

1994 • 12 citations

Molecular heterogeneity of angiotensin converting enzyme in human cerebrospinal fluid.

1991 • 12 citations

Sodium cromoglycate, a tachykinin antagonist?

1994 • 11 citations

Characterization and autoradiographic mapping of [3H]CP96,345, a nonpeptide selective NK1 receptor antagonist in guinea pig lung

1995 • 11 citations

Characterization of guinea pig pulmonary neurokinin type 1 receptors using a novel antagonist ligand, [3H]FK888.

1993 • 10 citations

The roles of the putative third cytoplasmic loop and cytoplasmic carboxyl tail of NK-1 and NK-2 receptors in agonist stimulated second messenger responses in stably transfected CHO cells

1993 • 6 citations

3H-senktide binding in guinea-pig ileum: A comparison with 125I-bolton hunter substance P and 125I-bolton hunter eledoisin

1988 • 6 citations