Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Revised Criteria for the Classification of Rheumatoid Arthritis

1990 • 7,730 citations

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

1987 • 2,539 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis

1978 • 1,170 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

The Influence of HLA-DRB1 Genes on Disease Severity in Rheumatoid Arthritis

1992 • 520 citations

CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

1996 • 479 citations

Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis.

1996 • 433 citations

Divergent T-cell cytokine patterns in inflammatory arthritis.

1994 • 388 citations

Defining protective responses to pathogens: cytokine profiles in leprosy lesions

1991 • 375 citations

X-Ray Crystal Structure of HLA-DR4 (DRA*0101, DRB1*0401) Complexed with a Peptide from Human Collagen II

1997 • 357 citations

Speed congenics: a classic technique in the fast lane (relatively speaking)

1997 • 347 citations

Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association.

1995 • 310 citations

Expansion of unusual CD4+ T cells in severe rheumatoid arthritis

1997 • 286 citations

Interleukin‐10 inhibition of the progression of established collagen‐induced arthritis

1996 • 261 citations

Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis.

1995 • 252 citations

Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis.

1992 • 229 citations

The Molecular Basis of Susceptibility to Rheumatoid Arthritis

1994 • 218 citations

Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis.

1995 • 213 citations

Functional subsets of CD4 T cells in rheumatoid synovitis

1998 • 209 citations

Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110.

1989 • 200 citations

Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium.

1983 • 195 citations

Hla–drb1 alleles in polymyalgia rheumatica, giant cell arteritis, and rheumatoid arthritis

1994 • 191 citations

Functional properties of CD4+CD28− T cells in the aging immune system

1998 • 189 citations

Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome

1994 • 187 citations

Aging-related Deficiency of CD28 Expression in CD4+ T Cells Is Associated with the Loss of Gene-specific Nuclear Factor Binding Activity

1998 • 183 citations

Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis

1995 • 180 citations

Tissue cytokine patterns distinguish variants of rheumatoid synovitis.

1997 • 175 citations

Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin‐10 and interleukin‐4

1996 • 174 citations

Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis.

1994 • 159 citations

Association of HLA–Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the “shared epitope” hypothesis

1991 • 157 citations

Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: A mechanism for methotrexate-induced nodulosis in rheumatoid arthritis

1997 • 149 citations

Interleukin‐10 functions as an antiinflammatory cytokine in rheumatoid synovium

1996 • 144 citations

The Role of CD8+ CD40L+ T Cells in the Formation of Germinal Centers in Rheumatoid Synovitis

1998 • 142 citations

Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings

1996 • 136 citations

PATHOGENESIS OF RHEUMATOID ARTHRITIS

1997 • 128 citations

Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients.

1993 • 119 citations

The Repertoire of CD4+ CD28− T Cells in Rheumatoid Arthritis

1996 • 113 citations

The repertoire of CD4+ CD28- T cells in rheumatoid arthritis.

1996 • 111 citations

Pocket 4 of the HLA-DR(α,β 1*0401) molecule is a major determinant of T cells recognition of peptide.

1995 • 104 citations

A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis

1996 • 103 citations

Co‐stimulatory pathways controlling activation and peripheral tolerance of human CD4⁺CD28⁻ T cells

1997 • 100 citations

Oligoclonality of V beta 3 TCR chains in the CD8+ T cell population of rheumatoid arthritis patients.

1996 • 95 citations

Genetic epidemiology of rheumatoid arthritis.

1995 • 88 citations

Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis

1988 • 88 citations

Most African-American Patients with Rheumatoid Arthritis Do Not Have the Rheumatoid Antigenic Determinant (Epitope)

1995 • 87 citations

Classification of the neuronal ceroid‐lipofuscinoses: Expansion of the atypical forms

1995 • 84 citations

Strong primary selection for the Dw4 subtype of DR4 accounts for the HLA-DQw7 association with Felty's syndrome

1991 • 75 citations

Relationships among antigen presentation, cytokines, immune deviation, and autoimmune disease.

1995 • 75 citations

HLA transgenic mice as humanized mouse models of disease and immunity.

1998 • 72 citations

Inherited and noninherited risk factors in rheumatoid arthritis

1995 • 71 citations

Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis

1995 • 66 citations

Rheumatoid arthritis in Israeli Jews: shared sequences in the third hypervariable region of DRB1 alleles are associated with susceptibility.

1991 • 61 citations

Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis.

1990 • 61 citations

T Cell Receptor Repertoire in Rheumatoid Arthritis

1998 • 58 citations

Identification of clonally expanded T cells in rheumatoid arthritis using a sequence enrichment nuclease assay.

1996 • 48 citations

Epistatic modeling in rheumatoid arthritis: An application of the Risch theory

1993 • 46 citations

Multiple Mechanisms Support Oligoclonal T Cell Expansion in Rheumatoid Synovitis

1997 • 43 citations

Tolerance to a self-peptide from the third hypervariable region of HLA DRB1*0401 in rheumatoid arthritis patients and normal subjects.

1994 • 43 citations

Spread of clonal T-cell expansions in rheumatoid arthritis patients

1996 • 36 citations

T CELLS IN RHEUMATOID ARTHRITIS

1995 • 32 citations

CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles.

1996 • 32 citations

Vasculitis in rheumatoid arthritis

1994 • 31 citations

Use of T cell receptor/HLA-DRB1*04 molecular modeling to predict site-specific interactions for the DR shared epitope associated with rheumatoid arthritis

1997 • 27 citations

Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor

1997 • 22 citations

A linkage study across the T cell receptor A and T cell receptor B loci in families with rheumatoid arthritis

1997 • 13 citations