The Role of Neopterin as a Monitor of Cellular Immune Activation in Transplantation, Inflammatory, Infectious, and Malignant Diseases

Chemistry and biology of pteridines

1956 • 1,263 citations

Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.

1984 • 1,083 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Neopterin as a marker for activated cell-mediated immunity: Application in HIV infection

1988 • 573 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated plasmodium falciparum malaria

1989 • 438 citations

INCREASED MONOZYGOTIC TWINNING RATE AFTER OVULATION INDUCTION

1987 • 400 citations

THE STRUCTURE OF THE PHENYLALANINE-HYDROXYLATION COFACTOR

1963 • 378 citations

Neopterin as Marker for Activation of Cellular Immunity: Immunologic Basis and Clinical Application

1989 • 373 citations

Chemistry and biology of pteridines 1986

1987 • 335 citations

A New Pteridine-requiring Enzyme System for the Oxidation of Glyceryl Ethers

1964 • 294 citations

Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

1990 • 288 citations

Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present.

1990 • 239 citations

Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms.

1990 • 203 citations

Determination of neopterin in serum and urine.

1987 • 194 citations

GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia

1984 • 174 citations

VARIANT FORMS OF PHENYLKETONURIA

1976 • 171 citations

Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection

1990 • 161 citations

Pteridines as a new marker to detect human T cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants.

1983 • 154 citations

NEOPTERIN AS A NEW BIOCHEMICAL MARKER FOR DIAGNOSIS OF ALLOGRAFT REJECTION

1983 • 152 citations

Immune activation and the anaemia associated with chronic inflammatory disorders

1991 • 141 citations

Neopterin and interferon‐gamma in serum and cerebrospinal fluid of patients with HIV‐associated neurologic disease

1991 • 138 citations

Elevated serum neopterin levels in atherosclerosis

1991 • 137 citations

Urinary neopterin reflects clinical activity in patients with rheumatoid arthritis

1986 • 125 citations

Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1.

1992 • 123 citations

Surrogate markers for survival in patients with AIDS and AIDS related complex treated with zidovudine.

1991 • 121 citations

Determination of neopterine in human urine by reversed-phase high-performance liquid chromatography

1982 • 113 citations

Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1

1989 • 110 citations

D-erythro-neopterin plasma levels in intensive care patients with and without septic complications

1987 • 107 citations

Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species

1984 • 105 citations

Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment.

1990 • 103 citations

Serum neopterin changes in HIV-infected subjects: indicator of significant pathology, CD4 T cell changes, and the development of AIDS.

1989 • 102 citations

Simultaneous determination of neopterin and creatinine in serum with solid-phase extraction and on-line elution liquid chromatography.

1987 • 102 citations

Immune Activation during Measles: Interferon- and Neopterin in Plasma and Cerebrospinal Fluid in Complicated and Uncomplicated Disease

1990 • 100 citations

Neopterin as an index of immune response in patients with tuberculosis

1984 • 99 citations

Neopterin as a prognostic indicator in patients with carcinoma of the uterine cervix.

1986 • 98 citations

Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation

1989 • 94 citations

Neopterin as a predictive marker for disease progression in human immunodeficiency virus type 1 infection.

1989 • 92 citations

Clinical significance of neopterin for prognosis and follow-up in ovarian cancer.

1987 • 89 citations

POSTTRANSPLANT NEOPTERIN EXCRETION IN RENAL ALLOGRAFT RECIPIENTS—A RELIABLE DIAGNOSTIC AID FOR ACUTE REJECTION AND A PREDICTIVE MARKER OF LONG-TERM GRAFT SURVIVAL

1991 • 89 citations

Elevated neopterin and beta2-microglobulin levels in blood and cerebrospinal fluid occur early in HIV-1 infection

1989 • 88 citations

Biologische Psychiatrie

1988 • 87 citations

Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma.

1986 • 82 citations

Altered tryptophan and neopterin metabolism in cancer patients treated with recombinant interleukin 2.

1989 • 82 citations

The Biosynthesis of Pteridines

1971 • 78 citations

Human Biologic Response Modification by Interferon in the Absence of Measurable Serum Concentrations: A Comparative Trial of Subcutaneous and Intravenous Interferon-beta serine

1989 • 74 citations

Struktur und Synthese des Neopterins

1963 • 69 citations

NEOPTERIN AS A NEW BIOCHEMICAL MARKER IN THE CLINICAL MONITORING OF BONE MARROW TRANSPLANT RECIPIENTS

1984 • 67 citations

HIV isolation from cerebrospinal fluid in relation to immunological deficiency and neurological symptoms

1988 • 66 citations

Urinary neopterin concentrations vs total neopterins for clinical utility.

1989 • 61 citations

Macrophage activation in falciparum malaria as measured by neopterin and interferon-gamma

1990 • 58 citations

Immunization with Tween-ether-treated SIV adsorbed onto aluminum hydroxide protects monkeys against experimental SIV infection

1992 • 58 citations

Elevated Urinary Neopterin Levels in Patients with the Acquired Immunodeficiency Syndrome (AIDS). A Preliminary Report

1983 • 57 citations

Neopterin

1992 • 57 citations

Immunologic Markers of Progression to Acquired Immunodeficiency Syndrome are Time-Dependent and Illness-Specific

1992 • 55 citations

Urinary neopterine as marker for haematological neoplasias

1981 • 55 citations

Value of urinary neopterin in the differential diagnosis of bacterial and viral infections

1990 • 54 citations

Urinary neopterin levels in acute viral hepatitis

1988 • 53 citations

Neopterin as a New Biochemical Marker in the Clinical Assessment of Ulcerative Colitis

1985 • 51 citations

Serum-Neopterinbestimmung zur zusätzlichen Sicherung der Bluttransfusion: Erfahrungen an 76 587 Blutspendern

2008 • 51 citations

Neopterin: a predictive marker of acquired immune deficiency syndrome in human immunodeficiency virus infection.

1989 • 50 citations

Neopterin: Isolation from Human Urine

1967 • 48 citations

Increased serum neopterin in patients with HIV-1 infection is correlated with reduced in vitro interleukin-2 production

1990 • 48 citations

CSF neopterin as marker of disease activity in multiple sclerosis

1987 • 47 citations

Immune activation markers to predict AIDS and survival in HIV-1 seropositives

1990 • 45 citations

Association between the activation of macrophages, changes of iron metabolism and the degree of anaemia in patients with malignant disorders

1992 • 45 citations

Significance of urinary neopterin in patients with malignant tumors of the genitourinary tract

1985 • 44 citations

The Effect of Zidovudine Treatment on Serum Neopterin and ??2-Microglobulin Levels in Mildly Symptomatic, HIV Type 1 Seropositive Individuals

1992 • 43 citations

Urinary neopterin in the diagnosis of acquired immune deficiency syndrome

1984 • 41 citations

Different lymphoid cell populations produce varied levels of neopterin, β2-microglobulin and soluble IL-2 receptor when stimulated with IL-2, interferon-gamma or tumour necrosis factor-alpha

1992 • 39 citations

Pteridine excretion from cells as indicator of cell proliferation

1980 • 38 citations

POTENTIAL OF URINARY NEOPTERIN EXCRETION IN DIFFERENTIATING CHRONIC NON-A, NON-B HEPATITIS FROM FATTY LIVER

1987 • 38 citations

Comparison of serum neopterin levels and urinary neopterin excretion in renal allograft recipients.

1988 • 38 citations

Neopterin and β2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection

1991 • 38 citations

Urinary neopterin concentrations in rhesus monkeys after infection with simian immunodeficiency virus (SIVmac 251)

1989 • 38 citations

Elevated serum neopterin levels in sarcoidosis

1986 • 38 citations

Neopterin in Clinical Use

1989 • 38 citations

Serum Levels of Neopterin as Related to the Prognosis of Human Prostatic Carcinoma

1986 • 37 citations

Urinary neopterine in the assessment of lymphoid and myeloid neoplasia, and neopterine levels in haemolytic anaemia and benign monoclonal gammopathy

1982 • 37 citations

Neopterin augmentation of tumor necrosis factor production

1991 • 37 citations

Urinary neopterin in patients with systemic lupus erythematosus

1991 • 36 citations

Markers for disease progression in intravenous drug users infected with HIV-1

1991 • 36 citations

The dependence of cell-mediated immune activation in malaria on age and endemicity

1987 • 33 citations

Neopterin estimation compared with the ratio of T-cell subpopulations in persons infected with human immunodeficiency virus-1.

1988 • 32 citations

Serum kynurenine and neopterin concentrations in patients with cardiomyopathy

1992 • 32 citations

KURZMITTEILUNG

1982 • 31 citations

A Simple Index Relating Clinical Activity in Crohn's Disease with T Cell Activation: Hematocrit, Frequency of Liquid Stools and Urinary Neopterin as Parameters

1986 • 30 citations

Prognostic significance of urinary neopterin levels in patients with hepatocellular carcinoma.

1988 • 29 citations

Cerebrospinal fluid and serum neopterin levels in patients with Lyme neuroborreliosis

1990 • 29 citations

Patterns of Serological Markers for Cellular Immune Activation in Patients with Dilated Cardiomyopathy and Chronic Myocarditis

1992 • 28 citations

A direct comparison of biological response modulation and clinical side effects by interferon-beta ser, interferon-gamma, or the combination of interferons beta ser and gamma in humans.

1990 • 26 citations

Changes of serum neopterin, beta 2-microglobulin and interferon-gamma in patients with chronic hepatitis C treated with interferon-alpha 2b.

1992 • 26 citations

Urinary Neopterin in Pulmonary Sarcoidosis: Relationship to Clinical and Biologic Assessment of the Disease

1989 • 25 citations

AUTOMATIZED ROUTINE ESTIMATION OF NEOPTERIN IN HUMAN URINE BY HPLC ON REVERSED PHASE

1982 • 24 citations

Neopterin levels in long-term hemodialysis.

1988 • 24 citations

Markers for Pancreas-Graft Rejection in Humans

1989 • 24 citations

Prognostic relevance of urinary neopterin in non-Hodgkin's lymphomas

1989 • 23 citations

Urinary neopterin excretion in pulmonary sarcoidosis: Correlation to clinical course of the disease

1988 • 23 citations

Liver involvement in human schistosomiasis mansoni. Assessment by immunological and biochemical markers

1988 • 22 citations

Correlation between synovial neopterin and inflammatory activity in rheumatoid arthritis.

1989 • 22 citations

Neopterin excretion after liver transplantation and its value in differential diagnosis of complications.

1989 • 22 citations

Acute lymphoid changes and ongoing immune activation in SIV infection.

1992 • 22 citations

Is schizophrenia linked to alteration in cellular immunity?

1989 • 21 citations

Neopterin screening and acute cytomegalovirus infections in blood donors

1992 • 19 citations

Neopterin as a new marker to detect acute rejection after heart transplantation.

1989 • 19 citations

Comparison of clinical efficacy and toxicity of conventional and optimum biological response modifying doses of interferon alpha-2C in the treatment of hairy cell leukemia: a retrospective analysis of 39 patients.

1989 • 18 citations

Activation of cellular immune responses in melioidosis patients as assessed by urinary neopterin

1990 • 17 citations

Urinary Neopterin as a Prognostic Factor in Haematological Neoplasias

1989 • 17 citations

Distinct Distributions of D-erythro-Neopterin in Arteries and Veins and its Recovery by an Enterohepatic Circulation

1992 • 16 citations

Effects of various inhibitors of phenylethanolamine N-methyltransferase on pulsatile release of LH in ovariectomized rats

1986 • 16 citations

Neopterin concentrations in pediatric human immunodeficiency virus infection as predictor of disease activity

1992 • 15 citations

Enhanced Serum Levels of β-2-Microglobulin, Neopterin, and Interferon-γ in Patients Treated with Recombinant Tumor Necrosis Factor-α

1988 • 15 citations

Neopterin as a marker for the activity of autoimmune thyroid diseases

1986 • 10 citations

Urinary neopterin excretion in patients with uterine sarcomas

1990 • 9 citations

Serum Neopterin Levels in Lung and Breast Cancer Patients Undergoing Radiotherapy And/Or Chemotherapy

1988 • 9 citations

Pancreatic juice neopterin excretion--reliable marker for detection of pancreatic allograft rejection.

1990 • 9 citations

URINARY NEOPTERIN IN PATIENTS WITH HEAD AND NECK CANCER

1982 • 8 citations

Is neopterin--a marker of cell mediated immune response--helpful in classifying leprosy?

1986 • 8 citations

Course of Immune Activation Markers in Patients after Severe Multiple Trauma

1990 • 7 citations

The Clinical Significance of Urinary Neopterin in the Follow-up of Patients after Exeresis of a Malignant Melanoma

1989 • 7 citations

Neopterin

1987 • 7 citations

Urinary Neopterin as Marker for Disease Activity in Children and Adolescents with Crohn’s Disease

1990 • 6 citations

Neopterin and Endogenous Interferon Gamma in Serum of Patients with Epstein-Barr Virus-associated Lymphoproliferative Diseases

1990 • 6 citations

Distinct Neopterin Excretion Patterns after Vaccination

1990 • 5 citations

Neopterinbestimmungen zum Screening von Spongiosaspendern

2008 • 3 citations

Deleted Work

1955 • 0 citations