Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment

The Hallmarks of Cancer

2000 • 27,569 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

1999 • 937 citations

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1994 • 777 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.

1994 • 634 citations

Neurofibromas in NF1: Schwann Cell Origin and Role of Tumor Environment

2002 • 607 citations

Mouse Models of Tumor Development in Neurofibromatosis Type 1

1999 • 465 citations

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1998 • 445 citations

Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway

1990 • 193 citations

Genetic and Biochemical Evidence That Haploinsufficiency of the Nf1 Tumor Suppressor Gene Modulates Melanocyte and Mast Cell Fates in Vivo

2000 • 184 citations

Tumors of the Peripheral Nervous System

2013 • 155 citations

Nf1-Deficient Mouse Schwann Cells Are Angiogenic and Invasive and Can Be Induced To Hyperproliferate: Reversion of Some Phenotypes by an Inhibitor of Farnesyl Protein Transferase

1997 • 140 citations

Haplo-insufficiency? Let me count the ways: Figure 1.

2001 • 111 citations

Accommodating haploinsufficient tumour suppressor genes in Knudson's model

2000 • 109 citations

The Nf1 Tumor Suppressor Regulates Mouse Skin Wound Healing, Fibroblast Proliferation, and Collagen Deposited by Fibroblasts

1999 • 107 citations

Tumors of the Peripheral Nervous System

2000 • 88 citations