The Nf1 Tumor Suppressor Regulates Mouse Skin Wound Healing, Fibroblast Proliferation, and Collagen Deposited by Fibroblasts

Wound Healing--Aiming for Perfect Skin Regeneration

1997 • 4,630 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Dermatology in General Medicine.

1987 • 4,066 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

Neurofibromatosis, Phenotype, Natural History, and Pathogenesis

1992 • 789 citations

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1994 • 777 citations

PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

1990 • 689 citations

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

1992 • 648 citations

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.

1994 • 634 citations

The Skin

1988 • 629 citations

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

1992 • 583 citations

A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severity.

1989 • 504 citations

Wound repair in the context of extracellular matrix

1994 • 435 citations

Type 1 neurofibromatosis: A descriptive analysis of the disorder in 1,728 patients

1997 • 411 citations

Differentiation of axon-related Schwann cells in vitro. I. Ascorbic acid regulates basal lamina assembly and myelin formation.

1987 • 393 citations

An analysis of variation in expression of neurofibromatosis (NF) type 1 (NF1): evidence for modifying genes.

1993 • 384 citations

Nf1 deficiency causes Ras-Dediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

1996 • 310 citations

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

1997 • 282 citations

Growth factors in skeletal muscle regeneration

1996 • 272 citations

Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene

1995 • 253 citations

Requirement of Drosophila NF1 for Activation of Adenylyl Cyclase by PACAP38-Like Neuropeptides

1997 • 210 citations

The Role of Macrophages in Wound Repair

1981 • 205 citations

Lysyl Oxidase and rrg Messenger RNA

1991 • 205 citations

SEGMENTAL RESPONSE OF THE MACROPHAGE PLASMA MEMBRANE TO A PHAGOCYTIC STIMULUS

1974 • 182 citations

PDGF and TGF-α Act Synergistically to Improve Wound Healing in the Genetically Diabetic Mouse

1994 • 175 citations

Identification of NF1 mutations in both alleles of a dermal neurofibroma

1996 • 172 citations

[17] Determination of 3- and 4-hydroxyproline

1982 • 171 citations

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

1995 • 158 citations

Cellular differentiation and expression of matrix genes in type 1 neurofibromatosis.

1988 • 151 citations

Ras-GTP levels are elevated in human NF1 peripheral nerve tumors.

1996 • 144 citations

Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras.

1993 • 143 citations

Nf1-Deficient Mouse Schwann Cells Are Angiogenic and Invasive and Can Be Induced To Hyperproliferate: Reversion of Some Phenotypes by an Inhibitor of Farnesyl Protein Transferase

1997 • 140 citations

Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes.

1995 • 131 citations

Homeotic transformation of cervical vertebrae in Hoxa-4 mutant mice.

1994 • 121 citations

Neurofibromatosis: Phenotype, Natural History and Pathogenesis

1993 • 100 citations

Cytokines and cell growth control.

1991 • 64 citations

Regulation of collagen I gene expression by ras.

1992 • 63 citations

Type 1 neurofibromatosis: selective expression of extracellular matrix genes by Schwann cells, perineurial cells, and fibroblasts in mixed cultures.

1989 • 53 citations

Neurofibromin-deficient fibroblasts fail to form perineurium in vitro

1995 • 48 citations

Collagens in Neurofibromas and Neurofibroma Cell Cultures

1986 • 48 citations

Upregulation of Tumor Suppressor Protein Neurofibromin in Normal Human Wound Healing and In Vitro Evidence for Platelet Derived Growth Factor (PDGF) and Transforming Growth Factor-β1 (TGF-β1) Elicited Increase in Neurofibromin mRNA Steady-State Levels in Dermal Fibroblasts

1998 • 46 citations

Localization of Neurofibromin to Keratinocytes and Melanocytes in Developing Rat and Human Skin

1994 • 42 citations

Neurofibromin: expression by normal human keratinocytes in vivo and in vitro and in epidermal malignancies.

1995 • 29 citations

Post-Transcriptional Regulation of Neurofibromin Level in Cultured Human Melanocytes in Response to Growth Factors

1997 • 28 citations

Chemoattractants and growth factors

1992 • 28 citations

Connective Tissue Biochemistry of Neurofibromasa

1986 • 21 citations

Neurofibromatosis Type 1: Genetic and Cellular Mechanisms of Peripheral Nerve Tumor Formation

1997 • 21 citations

Collagen synthesis in cells cultured from v. Recklinghausen's neurofibromatosis

1981 • 20 citations

Presence of type I and VI collagen mRNAs in endothelial cells in cutaneous neurofibromas.

1991 • 18 citations

RECKLINGHAUSEN'S NEUROFIBROMATOSIS

1951 • 18 citations

Differential contribution of M_r 120 kDa rasGTPase‐activating protein and neurofibromatosis type 1 gene product during the transition from growth phase to arrested state in human fibroblasts accompanied by a unique rasGTPase‐activating active

1993 • 15 citations

Regulation of Collagen I Gene Expression by ras

1992 • 15 citations

Regulation of Collagen Gene Expression by Transformed Human Fibroblasts: Decreased Type I and Type III Collagen RNA Transcription

1991 • 14 citations

Neurofibromatous dermal hypoplasia: a clinical, pharmacological and ultrastructural study

1985 • 11 citations

Increased deposition of types III and V collagen in neurofibroma tissue from patients with von recklinghausen disease

1989 • 10 citations

Growth and Collagen Synthesis of Cultured Neurofibroma Fibroblasts

1992 • 7 citations