Possible role of cGMP in excitatory amino acid induced cytotoxicity in cultured cerebral cortical neurons

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists

1988 • 1,202 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

Retinal degeneration in the rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase

1990 • 841 citations

A Dissection and tissue culture manual of the nervous system

1989 • 762 citations

On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins

1986 • 510 citations

Rat cortical neurons in cell culture: Culture methods, cell morphology, electrophysiology, and synapse formation

1978 • 482 citations

2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation

1981 • 468 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Glutamate acting on NMDA receptors stimulates neurite outgrowth from cerebellar granule cells

1987 • 316 citations

Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions

1982 • 298 citations

Direct evidence for involvement of a guanine nucleotide-binding protein in chemotactic peptide-stimulated formation of inositol bisphosphate and trisphosphate in differentiated human leukemic (HL-60) cells. Reconstitution with Gi or Go of the plasma membranes ADP-ribosylated by pertussis toxin.

1986 • 276 citations

Cyclic GMP Accumulation Causes Degeneration of Photoreceptor Cells: Simulation of an Inherited Disease

1977 • 232 citations

Dantrolene Prevents Glutamate Cytotoxicity and Ca²⁺ Release from Intracellular Stores in Cultured Cerebral Cortical Neurons

1991 • 232 citations

Excitatory amino acid-induced release of 3H-GABA from cultured mouse cerebral cortex interneurons

1987 • 224 citations

Activation of cerebral guanylate cyclase by nitric oxide

1977 • 212 citations

Stimulation of the receptor has a trophic effect on differentiating cerebellar granule cells

1988 • 212 citations

Inositol lipids in cell signalling.

1989 • 212 citations

Direct Evidence That Excitotoxicity in Cultured Neurons Is Mediated via N‐Methyl‐D‐Aspartate (NMDA) as well as Non‐NMDA Receptors

1989 • 208 citations

Cellular Origins of Cyclic GMP Responses to Excitatory Amino Acid Receptor Agonists in Rat Cerebellum In Vitro

1987 • 196 citations

A Kainate Receptor Linked to Nitric Oxide Synthesis from Arginine

1989 • 186 citations

Mechanisms by which diazepam, muscimol, and other drugs change the content of cGMP in cerebellar cortex

1977 • 165 citations

Development of excitatory amino acid induced cytotoxicity in cultured neurons

1990 • 148 citations

Excitatory amino acid receptors coupled with guanylate cyclase in primary cultures of cerebellar granule cells

1987 • 146 citations

Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo

1989 • 122 citations

Ontogenetic development of glutamate and GABA metabolizing enzymes in cultured cerebral cortex interneurons and in cerebral cortex in vivo

1985 • 114 citations

Different coupling of excitatory amino acid receptors with Ca2+ channels in primary cultures of cerebellar granule cells

1985 • 110 citations

Cultured Neurons as Model Systems for Biochemical and Pharmacological Studies on Receptors for Neurotransmitter Amino Acids

1985 • 102 citations

Calcium in the Brain under Physiological and Pathological Conditions

1990 • 101 citations

Cyclic GMP and cell death in rat cerebellar slices

1988 • 92 citations

Time and concentration dependency of the toxicity of excitatory amino acids on cerebral neurones in primary culture

1987 • 86 citations

Pharmacologically distinct glutamate receptors on cerebellar granule cells

1986 • 79 citations

GTP-binding proteins as possible targets for protein kinase C action

1989 • 79 citations

Model Systems of Development and Aging of the Nervous System

1987 • 78 citations

cGMP synthesis in cultured cerebellar neurons is stimulated by glutamate via a Ca2+-mediated, differentiation-dependent mechanism

1987 • 75 citations

Guanylate cyclase activities in enriched preparations of neurones, astroglia and a synaptic complex isolated from rat cerebellum

1986 • 75 citations

Transport of L-proline by rat brain slices

1976 • 74 citations

Glutamate receptor activation in cultured cerebellar granule cells increases cytosolic free Ca2+ by mobilization of cellular Ca2+ and activation of Ca2+ influx

1989 • 72 citations

Hormone and growth factor receptor-mediated regulation of phospholipase C activity

1989 • 64 citations

Activation of polyphosphoinositide metabolism as a signal‐transducing system coupled to excitatory amino acid receptors in astroglial cells

1989 • 63 citations

Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection

1991 • 63 citations

Prevention of natural motoneurone cell death by dibutyryl cyclic GMP

1984 • 60 citations

Primary Cultures of GABaergic and Glutamatergic Neurons as Model Systems to Study Neurotransmitter Functions II. Developmental Aspects

1987 • 50 citations

The agonist effect of Bay K 8644 on neuronal calcium channel currents is promoted by G-protein activation

1988 • 43 citations

Novel Glutamate Receptor Antagonists Selectively Protect Against Kainic Acid Neurotoxicity in Cultured Cerebral Cortex Neurons

1990 • 37 citations

Development of binding sites for excitatory amino acids in cultured cerebral cortex neurons

1991 • 21 citations

Glutamate‐Induced ⁴⁵Ca²⁺ Uptake into Immature Cerebral Cortex Neurons Shows a Distinct Pharmacological Profile

1989 • 16 citations