Development of excitatory amino acid induced cytotoxicity in cultured neurons

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

1993 • 2,272 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Kainic acid as a tool in neurobiology

1978 • 1,314 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

Rat cortical neurons in cell culture: Culture methods, cell morphology, electrophysiology, and synapse formation

1978 • 482 citations

Neurotoxicity of excitatory amino acids

1990 • 466 citations

Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro

1985 • 464 citations

Delayed neurotoxicity of excitatory amino acids In vitro

1987 • 332 citations

New class of glutamate agonist structurally related to ibotenic acid

1980 • 309 citations

Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase

1988 • 309 citations

Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions

1982 • 298 citations

ACTION OF THE NEUROTOXIN KAINIC ACID ON HIGH AFFINITY UPTAKE OF <scp>l</scp>‐GLUTAMIC ACID IN RAT BRAIN SLICES

1979 • 263 citations

Neuroscience approached through cell culture

1982 • 251 citations

The effect of potassium on neuronal differentiation in cultures of dissociated newborn rat cerebellum

1972 • 244 citations

EFFECTS OF SODIUM GLUTAMATE ON THE NERVOUS SYSTEM

1954 • 235 citations

The maintenance and identification of mouse cerebellar granule cells in monolayer culture

1977 • 230 citations

NMDA receptors and ligands in the vertebrate CNS

1988 • 226 citations

Excitatory amino acid-induced release of 3H-GABA from cultured mouse cerebral cortex interneurons

1987 • 224 citations

Effects of In Vivo Administration of Kainic Acid on the Extracellular Amino Acid Pool in the Rabbit Hippocampus

1983 • 213 citations

A glutamate receptor regulates Ca2+ mobilization in hippocampal neurons.

1988 • 210 citations

Direct Evidence That Excitotoxicity in Cultured Neurons Is Mediated via N‐Methyl‐D‐Aspartate (NMDA) as well as Non‐NMDA Receptors

1989 • 208 citations

Alterations in Uptake and Release Rates for GABA, Glutamate, and Glutamine During Biochemical Maturation of Highly Purified Cultures of Cerebral Cortical Neurons, a GABAergic Preparation

1984 • 153 citations

Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures

1988 • 124 citations

Neuronal Cells from Chick Embryo Cerebral Hemispheres Cultivated on Polylysine-Coated Surfaces

1978 • 124 citations

Chaotropic Ions Affect the Conformation of Quisqualate Receptors in Rat Cortical Membranes

1988 • 123 citations

Ontogenetic development of glutamate and GABA metabolizing enzymes in cultured cerebral cortex interneurons and in cerebral cortex in vivo

1985 • 114 citations

Biochemical correlates of GABA function in rat cortical neurons in culture

1980 • 111 citations

Different coupling of excitatory amino acid receptors with Ca2+ channels in primary cultures of cerebellar granule cells

1985 • 110 citations

Cultured Neurons as Model Systems for Biochemical and Pharmacological Studies on Receptors for Neurotransmitter Amino Acids

1985 • 102 citations

Ontogenetic development of glutamate metabolizing enzymes in cultured cerebellar granule cells and in cerebellumin vivo

1985 • 101 citations

Selection of a pure cerebellar granule cell culture by kainate treatment

1989 • 96 citations

Glutamate Receptor Subtypes in Cultured Cerebellar Neurons: Modulation of Glutamate and γ‐Aminobutyric Acid Release

1987 • 87 citations

Time and concentration dependency of the toxicity of excitatory amino acids on cerebral neurones in primary culture

1987 • 86 citations

Uptake of glutamate, GABA, and glutamine into a predominatly GABA‐ergic and a predominantly glutamatergic nerve cell population in culture

1982 • 84 citations

Pharmacologically distinct glutamate receptors on cerebellar granule cells

1986 • 79 citations

Transport of L-proline by rat brain slices

1976 • 74 citations

Glutamate receptor agonists increase intracellular Ca2+ independently of voltage-gated Ca2+ channels in rat cerebellar granule cells

1989 • 73 citations

Glutamate receptor activation in cultured cerebellar granule cells increases cytosolic free Ca2+ by mobilization of cellular Ca2+ and activation of Ca2+ influx

1989 • 72 citations

Differences between GABA Receptor Binding to Membranes from Cerebellum during Postnatal Development and from Cultured Cerebellar Granule Cells

1982 • 72 citations

Potassium‐Stimulated Release of [³HJTaurine from Cultured GABAergic and Glutamatergic Neurons

1989 • 53 citations

Amino acid neurotoxicity: Intracellular sites of calcium accumulation associated with the onset of irreversible damage to rat cerebellar neurones in vitro

1986 • 53 citations

In Vivo Microdialysis Studies on the Effects of Decortication and Excitotoxic Lesions on Kainic Acid‐Induced Calcium Fluxes, and Endogenous Amino Acid Release, in the Rat Striatum

1987 • 46 citations

Long-Term Alterations in Amino Acid-Induced Ionic Conductances in Chronic Epilepsy

1986 • 39 citations

Development of Excitatory Amino Acid Dependent ⁴⁵Ca²⁺ Uptake in Cultured Cerebral Cortex Neurons

1989 • 11 citations