X‐ray crystallographic structure of a papain‐leupeptin complex

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Proteases and biological control

1976 • 1,380 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Structure of papain refined at 1.65 Å resolution

1984 • 508 citations

The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.

1990 • 492 citations

Binding of chloromethyl ketone substrate analogs to crystalline papain

1976 • 352 citations

Low-Molecular-Weight Enzyme Inhibitors of Microbial Origin

1982 • 206 citations

An agarose mercurial column for the separation of mercaptopapain and nonmercaptopapain

1970 • 194 citations

Current problems in mechanistic studies of serine and cysteine proteinases

1982 • 165 citations

Crystal structure of a papain-E-64 complex

1989 • 150 citations

Contribution of the glutamine 19 side chain to transition-state stabilization in the oxyanion hole of papain

1991 • 133 citations

Transition-state stabilization at the oxyanion binding sites of serine and thiol proteinases: hydrolyses of thiono and oxygen esters

1983 • 85 citations

Thiohemiacetal formation by inhibitory aldehydes at the active site of papain

1977 • 83 citations

Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution

1991 • 70 citations

Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites

1992 • 68 citations

Active and Inactive Forms of the Transition-state Analog Protease Inhibitor Leupeptin: Explanation of the Observed Slow Binding of Leupeptin to Cathepsin B and Papain

1989 • 56 citations

Inhibition of Papain by N‐Acyl‐aminoacetaldehydes and N‐Acyl‐aminopropanones

1977 • 49 citations

Mechanism of action of cysteine proteinases: oxyanion binding site is not essential in the hydrolysis of specific substrates

1985 • 47 citations

Chapter 2 Cysteine proteinases

1987 • 46 citations

Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis.

1986 • 43 citations

Successful treatment of murine muscular dystrophy with the proteinase inhibitor leupeptin.

1981 • 38 citations

Carbon-13 NMR study of the stereospecificity of the thiohemiacetals formed on inhibition of papain by specific enantiomeric aldehydes

1986 • 38 citations

Mechanism of thiol protease catalysis: detection and stabilization of a tetrahedral intermediate in papain catalysis

1979 • 35 citations

Mechanism of association of N-acetyl-L-phenylalanylglycinal to papain

1981 • 33 citations

Mechanism of action of papain with a specific anilide substrate

1979 • 30 citations

[19] Peptide aldehydes: Potent inhibitors of serine and cysteine proteases

1977 • 29 citations

Inhibition of chicken calpain II by proteins of the cystatin superfamily and α2-macroglobulin

1987 • 22 citations

The proteinase inhibitors leupeptin, pepstatin A, and TLCK cause reduced collagen production in freshly isolated embryonic chick fibroblasts in suspension culture

1984 • 11 citations