The proteinase inhibitors leupeptin, pepstatin A, and TLCK cause reduced collagen production in freshly isolated embryonic chick fibroblasts in suspension culture

Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins

1971 • 1,396 citations

Proteinases in mammalian cells and tissues

1978 • 701 citations

PROTEIN DEGRADATION IN CULTURED CELLS

1974 • 603 citations

Evidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from N^α-Tosyl-L-lysine^*

1965 • 521 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Receptor-Mediated Endocytosis of Hormones in Cultured Cells

1981 • 388 citations

Ammonia inhibits phagosome–lysosome fusion in macrophages

1980 • 339 citations

Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon

1971 • 280 citations

Chloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: Apparent inhibition of receptor recycling

1980 • 252 citations

Mannose-specific endocytosis receptor of alveolar macrophages: demonstration of two functionally distinct intracellular pools of receptor and their roles in receptor recycling.

1982 • 211 citations

Direct evidence of importance of lysosomes in degradation of intracellular proteins

1975 • 209 citations

Intracellular degradation of newly synthesized secretory proteins

1983 • 158 citations

Control of collagen production by human diploid lung fibroblasts.

1980 • 158 citations

Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes

1978 • 101 citations

Specific inhibition by NH4Cl of autophagy-associated proteolysis in cultured fibroblasts

1978 • 94 citations

Kinetics for the secretion of procollagen by freshly isolated tendon cells

1977 • 89 citations

The inhibition of macrophage protein turnover by a selective inhibitor of thiol proteinases

1980 • 75 citations

Measurement of intracellular collagen degradation

1981 • 46 citations

Degradation of acetylcholine receptors in muscle cells: effect of leupeptin on turnover rate, intracellular pool sizes, and receptor properties.

1983 • 39 citations

Lysosomal function in the degradation of defective collagen in cultured lung fibroblasts

1984 • 34 citations

Inhibition of plasminogen activator release from transformed chicken fibroblasts by a protease inhibitor

1981 • 32 citations

Lysosomotropic agents ammonium chloride and chloroquine inhibit both the synthesis and secretion of procollagen by freshly isolated embryonic chick tendon cells

1982 • 28 citations

The Effect of Cis-4-Hydroxy-L-Proline on Intracellular Degradation of Newly Synthesized Collagen by Freshly Isolated Chick Tendon Fibroblasts

1982 • 19 citations

Lack of effect of NHCl on protein synthesis in cultured fibroblasts

1980 • 9 citations