A Single Aplysia Neurotrophin Mediates Synaptic Facilitation via Differentially Processed Isoforms

Trk Receptors: Roles in Neuronal Signal Transduction

2003 • 2,410 citations

Neurotrophins and their receptors: A convergence point for many signalling pathways

2003 • 2,173 citations

Regulation of Cell Survival by Secreted Proneurotrophins

2001 • 1,618 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

2004 • 1,084 citations

ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75^NTRand Sortilin

2005 • 927 citations

Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

2005 • 770 citations

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia

1986 • 767 citations

Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines

2008 • 604 citations

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1991 • 590 citations

Depolarization and cAMP Elevation Rapidly Recruit TrkB to the Plasma Membrane of CNS Neurons

1998 • 521 citations

Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation

2002 • 491 citations

Neuronal release of proBDNF

2009 • 424 citations

Sortilin Controls Intracellular Sorting of Brain-Derived Neurotrophic Factor to the Regulated Secretory Pathway

2005 • 386 citations

Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

1995 • 348 citations

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

2008 • 340 citations

Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons

1999 • 335 citations

Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade

2006 • 329 citations

Presynaptic BDNF Required for a Presynaptic but Not Postsynaptic Component of LTP at Hippocampal CA1-CA3 Synapses

2003 • 325 citations

BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons

2012 • 318 citations

Transactivation of Trk Neurotrophin Receptors by G-Protein-Coupled Receptor Ligands Occurs on Intracellular Membranes

2004 • 256 citations

Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

2009 • 250 citations

Signalling through the neurotrophin receptor p75NTR

1997 • 221 citations

Role of Transforming Growth Factor-β in Long-Term Synaptic Facilitation in Aplysia

1997 • 189 citations

Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization

1986 • 174 citations

Localization of Cellular Storage Compartments and Sites of Constitutive and Activity-Dependent Release of Nerve Growth Factor (NGF) in Primary Cultures of Hippocampal Neurons

1996 • 151 citations

Endogenous Truncated TrkB.T1 Receptor Regulates Neuronal Complexity and TrkB Kinase Receptor FunctionIn Vivo

2009 • 142 citations

Presynaptic Activation of Silent Synapses and Growth of New Synapses Contribute to Intermediate and Long-Term Facilitation in Aplysia

2003 • 139 citations

Nerve growth factor (NGF) induces sprouting of specific neurons of the snail, Lymnaea stagnalis

1991 • 131 citations

Truncated trkB.T1 Is Dominant Negative Inhibitor of trkB.TK+-Mediated Cell Survival

2001 • 127 citations

Activation of a Tyrosine Kinase-MAPK Cascade Enhances the Induction of Long-Term Synaptic Facilitation and Long-Term Memory in Aplysia

2003 • 120 citations

Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation

2008 • 118 citations

Identification of a Peptide Specific for Aplysia Sensory Neurons by PCR-based Differential Screening

1991 • 96 citations

Trophic factors: An evolutionary cul-de-sac or door into higher neuronal function?

2000 • 93 citations

A New Component in Synaptic Plasticity: Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex

2008 • 89 citations

Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants

1993 • 88 citations

Early evolutionary origin of the neurotrophin receptor family

1998 • 81 citations

Formation and Evolution of the Chordate Neurotrophin and Trk Receptor Genes

2006 • 79 citations

Serotonin Regulates the Secretion and Autocrine Action of a Neuropeptide to Activate MAPK Required for Long-Term Facilitation in Aplysia

2004 • 75 citations

Evolving better brains: a need for neurotrophins?

2001 • 71 citations

Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene

2000 • 69 citations

The single AmphiTrk receptor highlights increased complexity of neurotrophin signalling in vertebrates and suggests an early role in developing sensory neuroepidermal cells

2005 • 68 citations

ApTrkl, a Trk-like Receptor, Mediates Serotonin- Dependent ERK Activation and Long-Term Facilitation in Aplysia Sensory Neurons

2004 • 62 citations

A novel function for serotonin-mediated short-term facilitation in Aplysia : Conversion of a transient, cell-wide homosynaptic Hebbian plasticity into a persistent, protein synthesis-independent synapse-specific enhancement

2000 • 58 citations

Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation

2008 • 56 citations

A tropomyosin-related kinase B ligand is required for ERK activation, long-term synaptic facilitation, and long-term memory in Aplysia

2006 • 42 citations

Evolution of the Neurotrophin Signaling System in Invertebrates

2006 • 40 citations

Tracing the Evolution and Function of the Trk Superfamily of Receptor Tyrosine Kinases

2006 • 31 citations

Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai

2008 • 27 citations

The genome sequence of the protostome Daphnia pulex encodes respective orthologues of a neurotrophin, a Trk and a p75NTR: Evolution of neurotrophin signaling components and related proteins in the bilateria

2009 • 19 citations

Crystallization and characterization of the high molecular weight form of nerve growth factor (7 S NGF)

1991 • 19 citations

NGF and proNGF Regulate Functionally Distinct mRNAs in PC12 Cells: An Early Gene Expression Profiling

2011 • 18 citations