Evolution of the Neurotrophin Signaling System in Invertebrates

Trk Receptors: Roles in Neuronal Signal Transduction

2003 • 2,410 citations

Tunicates and not cephalochordates are the closest living relatives of vertebrates

2006 • 1,587 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75^NTRand Sortilin

2005 • 927 citations

p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

2002 • 807 citations

A p75NTR and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein

2002 • 458 citations

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

2003 • 438 citations

Molecular Phylogeny and Divergence Times of Deuterostome Animals

2005 • 437 citations

A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors

2005 • 398 citations

TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration

2005 • 383 citations

NMR structure of the death domain of the p75 neurotrophin receptor

1997 • 301 citations

Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2

2005 • 252 citations

Proteolytic Processing of the p75 Neurotrophin Receptor and Two Homologs Generates C-Terminal Fragments with Signaling Capability

2003 • 244 citations

Evolution of the vertebrate neurotrophin and Trk receptor gene families

1999 • 190 citations

Wengen, a Member of the Drosophila Tumor Necrosis Factor Receptor Superfamily, Is Required for Eiger Signaling

2002 • 189 citations

Proteolytic processing of the Drosophila Spätzle protein by Easter generates a dimeric NGF-like molecule with ventralising activity

1998 • 183 citations

TROY, a Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily, Exhibits a Homology with Edar and Is Expressed in Embryonic Skin and Hair Follicles

2000 • 130 citations

The phylogenetic origins of the antigen‐binding receptors and somatic diversification mechanisms

2004 • 124 citations

A co-evolution perspective of the TNFSF and TNFRSF families in the immune system

2003 • 121 citations

Loss of ancestral genes in the genomic evolution ofCiona intestinalis

2005 • 83 citations

Early evolutionary origin of the neurotrophin receptor family

1998 • 81 citations

Formation and Evolution of the Chordate Neurotrophin and Trk Receptor Genes

2006 • 79 citations

Identification of Interleukin 1 Receptor-associated Kinase as a Conserved Component in the p75-Neurotrophin Receptor Activation of Nuclear Factor-κB

2002 • 76 citations

Evolving better brains: a need for neurotrophins?

2001 • 71 citations

The single AmphiTrk receptor highlights increased complexity of neurotrophin signalling in vertebrates and suggests an early role in developing sensory neuroepidermal cells

2005 • 68 citations

A Novel p75 Neurotrophin Receptor-Related Protein, NRH2, Regulates Nerve Growth Factor Binding to the TrkA Receptor

2004 • 67 citations

The Drosophila Tumor Necrosis Factor Receptor-associated Factor-1 (DTRAF1) Interacts with Pelle and Regulates NFκB Activity

2000 • 57 citations

Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor

1997 • 54 citations

Specific neurotrophin binding to leucine‐rich motif peptides of TrkA and TrkB

1995 • 34 citations

Neurotrophic activities of trk receptors conserved over 600 million years of evolution

2004 • 31 citations

Neurotrophic and Gliatrophic Contexts in <i>Drosophila</i>

2006 • 18 citations

Building Complex Brains – Missing Pieces in an Evolutionary Puzzle

2006 • 12 citations