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1987 • 11,429 citations

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1991 • 8,402 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

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1981 • 795 citations

p185^HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

1989 • 672 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

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1990 • 602 citations

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1989 • 592 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

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1989 • 513 citations

A secreted glycoprotein induced by estrogen in human breast cancer cell lines

1980 • 481 citations

p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor.

1989 • 479 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

1985 • 408 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.

1986 • 329 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

Direct Interaction of a Ligand for the erb B2 Oncogene Product with the EGF Receptor and p185 ^{erb B2}

1990 • 279 citations

A monoclonal antibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines.

1991 • 229 citations

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1984 • 209 citations

Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells.

1983 • 200 citations

A v-erbB-related protooncogene, c-erb-B-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma

1985 • 195 citations

ERBB2 amplification in breast cancer with a high rate of proliferation.

1991 • 191 citations

Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer.

1991 • 187 citations

Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.

1988 • 186 citations

Hormonal modulation of HER-2/neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines.

1990 • 162 citations

Human microvascular endothelial cells express receptors for platelet-derived growth factor.

1991 • 154 citations

Epidermal growth factor receptor (EGFr) as a marker for poor prognosis in node-negative breast cancer patients: Neu and tamoxifen failure

1990 • 147 citations

Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses.

1992 • 117 citations

A ligand for the erbB-2 oncogene product (gp30) induces differentiation of human breast cancer cells.

1992 • 90 citations

Characterization and Use of Monoclonal Antibodies for Isolation of Phosphotyrosyl Proteins from Retrovirus-Transformed Cells and Growth Factor-Stimulated Cells

1983 • 66 citations

Lactate dehydrogenase in estrogen-responsive human breast cancer cells.

1978 • 64 citations

Purification and characterization of the neu/erb B2 ligand-growth factor from bovine kidney.

1992 • 39 citations

Characterization and cloning of the gp30 ligand for the erbB-2 receptor, from human breast cancer cells

1993 • 1 citations