3-Amino-5-hydroxybenzoic Acid Synthase, the Terminal Enzyme in the Formation of the Precursor of mC7N Units in Rifamycin and Related Antibiotics

Basic local alignment search tool

1990 • 87,358 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

1992 • 1,371 citations

Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences

1986 • 575 citations

Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to a positively charged membrane filter

1982 • 428 citations

Aminotransferases: demonstration of homology and division into evolutionary subgroups

1993 • 401 citations

The codon preference plot: graphic analysis of protein coding sequences and prediction of gene expression

1984 • 381 citations

Evolutionary relationships among pyridoxal‐5′‐phosphate‐dependent enzymes

1994 • 368 citations

Cloning and analysis of the promoter region of the erythromycin-resistance gene (ermE) of Streptomyces erythraeus

1986 • 347 citations

Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2)

1991 • 346 citations

Modeling of the spatial structure of eukaryotic ornithine decarboxylases

1995 • 334 citations

A computer algorithm for testing potential prokaryotic terminators

1984 • 317 citations

Gene expression in Streptomyces: Construction and application of promoter-probe plasmid vectors in Streptomyces lividans

1982 • 316 citations

Disentangling electrospray spectra with maximum entropy

1992 • 256 citations

PATHWAYS AND MECHANISMS IN THE BIOGENESIS OF NOVEL DEOXYSUGARS BY BACTERIA

1994 • 223 citations

The Streptomyces plasmid SCP2∗: its functional analysis and development into useful cloning vectors

1985 • 208 citations

Chemical and biochemical aspects of deoxysugars and deoxysugar oligosaccharides

1997 • 175 citations

From glucose to aromatics: recent developments in natural products of the shikimic acid pathway

1978 • 170 citations

Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius

1992 • 167 citations

The Leeuwenhoek Lecture, 1987 - Towards an understanding of gene switching in Streptomyces , the basis of sporulation and antibiotic production

1988 • 145 citations

Molecular characterization of the Pseudomonas aeruginosa serotype O5 (PAO1) B‐band lipopolysaccharide gene cluster

1996 • 136 citations

Sequence and analysis of the O antigen gene (rfb) cluster of Escherichia coli 0111

1995 • 134 citations

Analysis of five tyiosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome

1994 • 124 citations

The identification, cloning and mutagenesis of a genetic locus required for lipopolysaccharide biosynthesis in Bordetella pertussis

1996 • 113 citations

Biosynthesis of 3-Amino-5-hydroxybenzoic Acid, the Precursor of mC₇N Units in Ansamycin Antibiotics

1996 • 92 citations

Serine Transhydroxymethylase: Spectral Properties of the Enzyme-bound Pyridoxal-5-phosphate

1962 • 87 citations

Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis

1989 • 82 citations

Pathway Engineering in Secondary Metabolite-Producing Actinomycetes

1994 • 79 citations

Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA

1994 • 78 citations

Biosynthesis of 3,6-dideoxyhexoses: new mechanistic reflections upon 2,6-dideoxy, 4,6-dideoxy, and amino sugar construction

1993 • 76 citations

Novel Vibrio cholerae O139 genes involved in lipopolysaccharide biosynthesis

1997 • 73 citations

Stereochemistry of pyridoxal phosphate catalyzed enzyme reactions

1980 • 73 citations

The Biosynthetic Pathway of the Aminonucleoside Antibiotic Puromycin, as Deduced from the Molecular Analysis of the pur Cluster of Streptomyces alboniger

1996 • 67 citations

A genetic approach to the biosynthesis of the Rifamycin-chromophore in Nocardia mediterranei. IV. Identification of 3-amino-5-hydroxybenzoic acid as a direct precursor of the seven-carbon amino starter-unit.

1981 • 67 citations

Identification of stsC , the gene encoding the l -glutamine: scyllo -inosose aminotransferase from streptomycin-producing Streptomycetes

1997 • 63 citations

3-Amino-5-hydroxybenzoic acid as a key intermediate in ansamycin and maytansinoid biosynthesis

1980 • 62 citations

Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA

1993 • 61 citations

Gabaculine: γ-aminobutyrate aminotransferase inhibitor of microbial origin

1976 • 55 citations

[30] Separation of peptides by reversed-phase high-performance liquid chromatography

1983 • 55 citations

Formation of 3-amino-5-hydroxybenzoic acid, the precursor of mC7N units in ansamycin antibiotics, by a new variant of the shikimate pathway

1992 • 55 citations

Nucleotide sequence and cloning in Bacillus subtilis of the Bacillus stearothermophilus pleiotropic regulatory gene degT

1990 • 54 citations

Blotting of proteins onto immobilon membranes

1989 • 50 citations

Biosynthetic origin of aminobenzenoid nucleus (C7N-unit) of ansamitocin, a group of novel maytansinoid antibiotics.

1982 • 45 citations

Biosynthesis of the mitomycin antibiotics from 3-amino-5-hydroxybenzoic acid

1980 • 44 citations

Die Synthese der 5‐Dehydro‐chinasäure

1956 • 41 citations

Mechanistic studies of the biosynthesis of 3,6-dideoxyhexoses in Yersinia pseudotuberculosis: purification and characterization of CDP-4-keto-6-deoxy-D-glucose-3-dehydrase

1992 • 36 citations

Mechanistic and stereochemical studies of a unique dehydration catalyzed by CDP-4-keto-6-deoxy-D-glucose-3-dehydrase: a pyridoxamine 5'-phosphate dependent enzyme isolated from Yersinia pseudotuberculosis

1992 • 30 citations

The application of ‘MaxEnt’ to high resolution mass spectrometry

1992 • 29 citations

Use of D-[13C6]glucose together with carbon-13-depleted glucose and homonuclear carbon-13 decoupling to identify the labeling pattern by this precursor of the "m-C7N" unit of geldanamycin

1982 • 28 citations

Coenzyme B6 as a redox cofactor: a new role for an old coenzyme?

1993 • 25 citations

Untersuchungen zur Biosynthese von Antibiotica

1989 • 24 citations

Electroporation of intact cells of Streptomyces parvulus and Streptomyces vinaceus

2006 • 22 citations

Biosynthesis of rifamycins (ansamycins) and microbial production of shikimate pathway precursors, intermediates and metabolites.

1985 • 21 citations

Biosynthetic origins of the oxygen atoms in the ansamycin antibiotics rifamycin B, O, and S

1989 • 19 citations

Stereochemistry of the enzymatic and non-enzymatic conversion of 3-dehydroshikimate into protocatechuate

1971 • 17 citations

Biosynthesis of ω-cyclohexyl fatty acids in Alicyclobacillus acidocaldarius: the stereochemistry of the initial 1,4-conjugate elimination

1997 • 14 citations

Similarity between pyridoxal/pyridoxamine phosphate‐dependent enzymes involved in dideoxy and deoxyaminosugar biosynthesis and other pyridoxal phosphate enzymes

1994 • 13 citations

Regulation of 3-deoxy-d-arabinoheptulosonic acid 7-phosphate synthetase inNocardia mediterranei

1982 • 10 citations