Abrupt Discontinuation of Tricyclic Antidepressant Drugs: Evidence for Noradrenergic Hyperactivity

Psychopharmacology: A Generation of Progress

1979 • 1,101 citations

Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines

1980 • 866 citations

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

1978 • 794 citations

Treatment of Endogenous Anxiety With Phobic, Hysterical, and Hypochondriacal Symptoms

1980 • 733 citations

Catecholamines: Basic and Clinical Frontiers

1979 • 730 citations

Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization

1977 • 712 citations

CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS

1978 • 705 citations

II. New evidence for a locus coeruleus-norepinephrine connection with anxiety

1979 • 666 citations

Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment

1981 • 645 citations

Mode of action of antidepressant drugs

1978 • 514 citations

Tricyclic Antidepressants: Long-Term Treatment Increases Responsivity of Rat Forebrain Neurons to Serotonin

1978 • 476 citations

Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants.

1978 • 440 citations

Feedback Inhibition of Brain Noradrenaline Neurons by Tricyclic Antidepressants: α-Receptor Mediation

1978 • 396 citations

Treatment of Agoraphobia With Group Exposure In Vivo and Imipramine

1980 • 335 citations

Presynaptic Alpha-Receptor Subsensitivity After Long-Term Antidepressant Treatment

1978 • 320 citations

Behavior Therapy, Supportive Psychotherapy, Imipramine, and Phobias

1978 • 245 citations

Tricyclic antidepressants: Effects on the firing rate of brain noradrenergic neurons

1975 • 224 citations

α2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment

1981 • 216 citations

Platelet α2-Adrenergic Receptors in Major Depressive Disorder

1981 • 215 citations

Conversion of MHPG to Vanillylmandelic Acid

1980 • 199 citations

Effects of chronic desipramine treatment on rat brain noradrenergic responses to α-adrenergic drugs

1980 • 187 citations

3-Methoxy-4-Hydroxyphenethyleneglycol Production by Human Brain in Vivo

1979 • 179 citations

Functional evidence for subsensitivity of noradrenergic α2 receptors after chronic desipramine treatment

1980 • 150 citations

The Clinical Use of Clonidine in Abrupt Withdrawal From Methadone

1981 • 148 citations

Presynaptic Adrenergic Receptor Sensitivity in Depression

1981 • 133 citations

Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence

1978 • 128 citations

Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates

1982 • 121 citations

Chronic antidepressant treatment enhances α-adrenergic and serotonergic responses in the facial nucleus

1980 • 120 citations

Presence of free, sulfate and glucuronide conjugated 3-methoxy-4-hydroxyphenylglycol (MHPG) in human brain, cerebrospinal fluid and plasma

1977 • 120 citations

WITHDRAWAL SYMPTOMS FOLLOWING DISCONTINUATION OF IMIPRAMINE THERAPY

1961 • 108 citations

Clonidine reversal of increased norepinephrine metabolite levels during morphine withdrawal

1979 • 107 citations

Hypomania and mania after withdrawal of tricyclic antidepressants

1981 • 95 citations

The effect of acute and chronic desipramine and amitriptyline treatment on rat brain total 3-methoxy-4-hydroxyphenylglycol

1978 • 89 citations

3-methoxy-4-hydroxyphenethylene glycol in plasma

1974 • 84 citations

Changes in rat brain monoamine turnover following chronic antidepressant administration

1980 • 79 citations

Blood and brain concentrations of imipramine, clomipramine and their monomethylated metabolites after oral and intramuscular administration in rats

1977 • 78 citations

Changes in Norepinephrine Turnover in Rat Brain During Chronic Administration of Imipramine and Protriptyline: A Possible Explanation for the Delay in Onset of Clinical Antidepressant Effects

1971 • 77 citations

TOFRANIL‐TREATMENT OF ENDOGENOUS DEPRESSIONS

1959 • 75 citations

Potentiation of responses to adrenergic nerve stimulation in isolated rat atria during chronic tricyclic antidepressant administration.

1980 • 68 citations

Antidepressants and alpha 2-adrenergic autoreceptor desensitization

1981 • 64 citations

The Switch Process in Manic-Depressive Psychosis

1977 • 60 citations

Clinical Experience with Imipramine (G 22355) in the Treatment of Depression

1959 • 58 citations

Interaction of antidepressants with clonidine on rat brain total 3-methoxy-4-hydroxyphenylglycol

1979 • 53 citations

Plasma MHPG in depression: Effects of acute and chronic desipramine treatment

1981 • 52 citations

Tricyclic antidepressant drug treatment decreases α2-adrenoreceptors on human platelet membranes

1981 • 49 citations

Withdrawal symptoms after graduated cessation of imipramine in children

1981 • 38 citations

II. Reliability, Validity, and Application

1970 • 36 citations

Imipramine Withdrawal: An Akathisia-Like Syndrome

1973 • 35 citations

Panic anxiety after abrupt discontinuation of amitriptyline

1981 • 34 citations

The occurrence of free vs. conjugated MHPG in non-human and human primate brain.

1976 • 29 citations

Withdrawal From Long-term High-Dose Desipramine Therapy

1978 • 28 citations

Withdrawal Symptoms after Abrupt Termination of Imipramine

1966 • 27 citations

Withdrawal Symptoms After Abrupt Cessation of Amitriptyline in an Eight-Year-Old Boy

1979 • 26 citations

Regulation of neurotransmission through presynaptic receptors and other mechanisms: possible clinical relevance and therapeutic potential.

1980 • 22 citations

Morphine withdrawal causes subsensitivity of adrenergic receptor response

1981 • 20 citations

ALPHA-ADRENORECEPTOR MEDIATED INHIBITION OF BRAIN NORADRENERGIC NEURONS AFTER ACUTE AND CHRONIC TREATMENT WITH TRICYCLIC ANTIDEPRESSANTS

1979 • 18 citations

Crossover study of zimelidine and desipramine in depression: evidence for amine specificity [proceedings].

1981 • 10 citations

Die moderne Behandlung der endogenen Depression

1965 • 5 citations