Mode of action of antidepressant drugs

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

Ascending Monoamine Neurons to the Telencephalon and Diencephalon

1966 • 1,205 citations

Norepinephrine in Depressive Reactions

1965 • 1,127 citations

Overview of Recent Research in Depression

1975 • 545 citations

Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.

1976 • 499 citations

Neuropsychopharmacology of monoamines and their regulatory enzymes.

1974 • 416 citations

A possible common mechanism of action of antidepressant treatments

1976 • 410 citations

A new selective inhibitor for uptake of serotonin into synaptosomes of rat brain: 3-(p-trifluoromethylphenoxy). N-methyl-3-phenylpropylamine.

1975 • 358 citations

Catecholamine Metabolism, Depressive Illness, and Drug Response

1972 • 341 citations

Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum

1974 • 289 citations

Parachlorophenylalanine Reversal of Tranylcypromine Effects in Depressed Patients

1976 • 263 citations

β-Adrenergic Receptor Involvement in 6-Hydroxydopamine-Induced Supersensitivity in Rat Cerebral Cortex

1976 • 238 citations

Tricyclic antidepressants: Effects on the firing rate of brain noradrenergic neurons

1975 • 224 citations

Neurochemical characterization of a new potent and selective serotonin uptake inhibitor: Lu 10-171

1977 • 174 citations

Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder.

1974 • 164 citations

ADAPTIVE MECHANISMS OF THE NORADRENERGIC CYCLIC AMP GENERATING SYSTEM IN THE LIMBIC FOREBRAIN OF THE RAT: ADAPTATION TO PERSISTENT CHANGES IN THE AVAILABILITY OF NOREPINEPHRINE (NE)^1,2

1976 • 136 citations

Animal Models in Psychiatry

1974 • 135 citations

Potentiation of the Antidepressant Action of Clomipramine by Tryptophan

1976 • 134 citations

Neurobiological mechanisms of adaptation and behavior

1975 • 133 citations

THE ACTION OF DESMETHYLIMIPRAMINE IN COUNTERACTING SEDATION AND CHOLINERGIC EFFECTS OF RESERPINE-LIKE DRUGS

1964 • 131 citations

Norepinephrine Turnover and Metabolism in Rat Brain after Long-Term Administration of Imipramine

1970 • 125 citations

Psychoactive drug effects on a system which generates cyclic AMP in brain

1976 • 124 citations

A new modification for studying 5-HT uptake by blood platelets: a re-evaluation of tricyclic antidepressants as uptake inhibitors

1974 • 117 citations

Mianserin Hydrochloride: A Novel Antidepressant

1976 • 112 citations

Effects of neurohumoral and adrenergic agents on cyclic amp levels in various areas of the rat brain in vitro

1973 • 112 citations

The pharmacology of iprindole, a new antidepressant

1969 • 111 citations

The noradrenergic cyclic AMP generating system in the limbic forebrain: Pharmacological characterization in vitro and possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics

1976 • 104 citations

Increased cyclic AMP response to norepinephrine in the rat brain following 6-hydroxydopamine

1972 • 99 citations

Effect of iprindole on norepinephrine turnover and transport

1974 • 93 citations

A comparison of the pharmacological and biochemical properties of substrate‐selective monoamine oxidase inhibitors

1972 • 92 citations

Iprindole-amphetamine interactions in the rat: the role of aromatic hydroxylation of amphetamine in its mode of action.

1972 • 90 citations

Phenethylamine content of human urine and rat brain, its alterations in pathological conditions and after drug administration

1972 • 90 citations

Toward a Biology of Depression: Some Suggestions from Neurophysiology

1969 • 85 citations

Effects of tricyclic antidepressants upon human platelet monoamine oxidase

1974 • 81 citations

Antidepressant evaluation and the pharmacological actions of FG4963 in depressive patients

1977 • 72 citations

Blockade by pimozide of a noradrenaline sensitive adenylate cyclase in the limbic forebrain: possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics

1975 • 70 citations

The tricyclic antidepressants—Inhibition of norepinephrine uptake as related to potentiation of norepinephrine and clinical efficacy

1971 • 59 citations

Changes in Primate Social Behavior After Treatment with Alpha-Methyl-Para-Tyrosine

1971 • 56 citations

Differential effects of reserpine and alpha-methyl-p-tyrosine on norepinephrine and dopamine induced behavioral activity

1973 • 54 citations

The effects of chronic imipramine administration on rat brain levels of serotonin, 5-hydroxyindoleacetic acid, norepinephrine and dopamine.

1972 • 53 citations

Comparative studies of a new 5HT-uptake inhibitor and some tricyclic thymoleptics

1975 • 43 citations

TRYPTOPHAN/IMIPRAMINE IN DEPRESSION

1975 • 41 citations

Effects of acute and chronic administration of desmethylimipramine on the content of norepinephrine and other monoamines in the rat brain

1973 • 39 citations

Effect of desmethylimipramine, iprindole and dl-erythro-α-(3,4-dichlorophenyl)-β-(t-butyl amino) propanol HCl on the metabolism of amphetamine

1970 • 39 citations

The influence of psychotropic drugs on the levels of endogenous 2-phenylethylamine in rabbit brain.

1974 • 35 citations

Altered responsiveness of adenosine 3′,5′-monophosphate-generating systems in rat cortical slices after lesions of the medial forebrain bundle

1975 • 32 citations

The limbic system: An interface

1974 • 31 citations

Iprindole and Imipramine in Non-Psychotic Depressed Out-Patients

1973 • 30 citations

TRICYCLIC ANTIDEPRESSANTS AND TRYPTOPHAN IN UNIPOLAR AFFECTIVE DISORDER

1972 • 23 citations

Effect of ECT on dopaminergic and noradrenergic mechanisms

1974 • 21 citations

Inhibition of rabbit monoamine oxidase by doxepin and related drugs

1975 • 15 citations

Effect of acute and chronic iprindole on serotonin turnover in mouse brain

1975 • 13 citations

A preliminary investigation of WY-3263 versus amitriptyline in depressions.

1968 • 12 citations

Inhibition of phenylethylamine metabolism in vivo—Effect of antidepressants

1976 • 10 citations

The role of adaptive regulation in the pathophysiology of psychiatric disease

1974 • 7 citations

Agonist effects of .beta.-phenethylamines on the noradrenergic cyclic adenosine 3',5'-monophosphate generating system in rat limbic forebrain. Stereoisomers of p-hydroxynorephedrine

1977 • 6 citations

The noradrenergic cyclic AMP generating system in the rat limbic forebrain and its stereospecificity for butaclamol

1976 • 6 citations

Chronic administration of electroconvulsive shock and norepinephrine metabolism in the rat brain

1969 • 6 citations