Cellular signaling by an agonist-activated receptor/Gs alpha fusion protein.

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

1992 • 623 citations

The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein.

1986 • 533 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α subunits

1992 • 441 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

G proteins control diverse pathways of transmembrane signaling ¹

1989 • 399 citations

Expression of Gsα in Escherichia coli

1989 • 262 citations

Partial agonists, full agonists, antagonists: dilemmas of definition

1993 • 234 citations

Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.

1992 • 205 citations

Mutations of Gs α Designed to Alter the Reactivity of the Protein with Bacterial Toxins

1989 • 177 citations

G alpha 13 stimulates Na-H exchange.

1994 • 175 citations

Carboxyl Rerminal Domain of G _sα Specifies Coupling of Receptors to Stimulation of Adenylyl Cyclase

1988 • 174 citations

Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.

1987 • 173 citations

Mechanisms of multifunctional signalling by G protein-linked receptors

1993 • 143 citations

G protein .beta..gamma. subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of .alpha. subunits by pertussis toxin but differential interactions with Gs.alpha.

1989 • 139 citations

Suppression of Ras-Induced Transformation of NIH 3T3 Cells by Activated Gα _S

1994 • 139 citations

Interactions of the bovine brain A1-adenosine receptor with recombinant G protein alpha-subunits. Selectivity for rGi alpha-3.

1991 • 116 citations

Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.

1990 • 109 citations

Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors.

1988 • 81 citations

Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions.

1992 • 75 citations

Deletion within the amino-terminal region of Gs alpha impairs its ability to interact with beta gamma subunits and to activate adenylate cyclase

1991 • 50 citations

Antigenic analysis of the second extra-cellular loop of the human beta-adrenergic receptors.

1989 • 47 citations

Guanine nucleotides regulate beta-adrenergic activation of Na-H exchange independently of receptor coupling to Gs.

1992 • 37 citations

A truncated recombinant alpha subunit of Gi3 with a reduced affinity for beta gamma dimers and altered guanosine 5'-3-O-(thio)triphosphate binding.

1992 • 33 citations

Down‐Regulation of β‐Adrenergic Receptors by Pindolol in G_sα‐Transfected S49 cyc⁻ Murine Lymphoma Cells

1992 • 10 citations