Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance
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References (66)
Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice
2013 • 3,921 citations
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
2001 • 3,785 citations
The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function
2003 • 3,746 citations
Neurotrophins as synaptic modulators
2001 • 1,773 citations
Regulation of Cell Survival by Secreted Proneurotrophins
2001 • 1,618 citations
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
1998 • 1,504 citations
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
1995 • 1,416 citations
NEUROTROPHINS AND SYNAPTIC PLASTICITY
1999 • 1,343 citations
The yin and yang of neurotrophin action
2005 • 1,279 citations
Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice
1996 • 1,219 citations
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
2003 • 1,212 citations
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
2005 • 1,155 citations
Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport
1997 • 1,093 citations
Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity
2004 • 1,084 citations
Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons
2004 • 862 citations
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
1990 • 748 citations
Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression
1998 • 687 citations
Neurotrophin secretion: current facts and future prospects
2003 • 648 citations
Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis
1991 • 636 citations
Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons.
1991 • 578 citations
Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor
2001 • 538 citations
Depolarization and cAMP Elevation Rapidly Recruit TrkB to the Plasma Membrane of CNS Neurons
1998 • 521 citations
Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses
2001 • 508 citations
Transport, capture and exocytosis of single synaptic vesicles at active zones
2000 • 464 citations
Transport, docking and exocytosis of single secretory granules in live chromaffin cells
1997 • 437 citations
Cellular Mechanisms Regulating Activity-Dependent Release of Native Brain-Derived Neurotrophic Factor from Hippocampal Neurons
2002 • 400 citations
BDNF Regulates the Translation of a Select Group of mRNAs by a Mammalian Target of Rapamycin-Phosphatidylinositol 3-Kinase-Dependent Pathway during Neuronal Development
2004 • 399 citations
Activity-Dependent Transfer of Brain-Derived Neurotrophic Factor to Postsynaptic Neurons
2001 • 366 citations
Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.
1996 • 350 citations
Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons
1999 • 335 citations
Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons
1997 • 333 citations
Activity-Dependent Release of Endogenous Brain-Derived Neurotrophic Factor from Primary Sensory Neurons Detected by ELISAIn Situ
2000 • 333 citations
Gene Expression Profiling of Facilitated L-LTP in VP16-CREB Mice Reveals that BDNF Is Critical for the Maintenance of LTP and Its Synaptic Capture
2005 • 323 citations
Characterization of Nerve Growth Factor (NGF) Release from Hippocampal Neurons: Evidence for a Constitutive and an Unconventional Sodium‐dependent Regulated Pathway
1995 • 319 citations
Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF
2004 • 318 citations
Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system
1996 • 284 citations
Neurotrophin release by neurotrophins: Implications for activity-dependent neuronal plasticity
1997 • 268 citations
Neurotrophins and activity-dependent plasticity
2000 • 257 citations
Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor
2004 • 246 citations
Relative Contribution of Endogenous Neurotrophins in Hippocampal Long-Term Potentiation
1999 • 242 citations
Neurotrophin secretion from hippocampal neurons evoked by long-term-potentiation-inducing electrical stimulation patterns
2002 • 192 citations
Activity- and Ca2+-Dependent Modulation of Surface Expression of Brain-Derived Neurotrophic Factor Receptors in Hippocampal Neurons
2000 • 178 citations
Down-regulation of the Neurotrophin Receptor TrkB following Ligand Binding
2000 • 160 citations
Are Neurotrophins Synaptotrophins?
1996 • 134 citations
Simultaneous evanescent wave imaging of insulin vesicle membrane and cargo during a single exocytotic event
2000 • 132 citations
Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity
1999 • 130 citations
It's green outside: tracking cell surface proteins with pH-sensitive GFP
2004 • 130 citations
Neurotrophins induce release of neurotrophins by the regulated secretory pathway
1998 • 124 citations
Brain-derived neurotrophic factor is an anterograde survival factor in the rat visual system
2000 • 123 citations
Neurotrophin release by neurotrophins: Implications fro activity dependent neurons.
1997 • 106 citations
Nitric oxide down-regulates brain-derived neurotrophic factor secretion in cultured hippocampal neurons
2002 • 102 citations
A Cell-Free System for Regulated Exocytosis in Pc12 Cells
2000 • 102 citations
Acute and long-term synaptic modulation by neurotrophins
2004 • 101 citations
Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways
2001 • 101 citations
Axonal transport and neuronal transcytosis of trophic factors, tracers, and pathogens
2003 • 100 citations
Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx
2003 • 99 citations
Sorting of Internalized Neurotrophins into an Endocytic Transcytosis Pathway via the Golgi System: Ultrastructural Analysis in Retinal Ganglion Cells
2001 • 83 citations
Localized Synaptic Actions of Neurotrophin-4
1998 • 71 citations
Mechanisms of neurotrophin receptor vesicular transport
2003 • 69 citations
Mechanisms of the Release of Anterogradely Transported Neurotrophin-3 from Axon Terminals
2002 • 60 citations
Provision of Brain-Derived Neurotrophic Factor via Anterograde Transport from the Eye Preserves the Physiological Responses of Axotomized Geniculate Neurons
2003 • 52 citations
Regulated delivery of AMPA receptor subunits to the presynaptic membrane
2003 • 48 citations
Anterograde axonal transport of BDNF and NT-3 by retinal ganglion cells: Roles of neurotrophin receptors
2005 • 40 citations
Spatially Restricted Actions of BDNF
2002 • 32 citations
Prolonged recycling of internalized neurotrophins in the nerve terminal
2001 • 29 citations
Cell-specific expression of the epm1 (cystatin B) gene in developing rat cerebellum
2005 • 27 citations