Back to search

Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance

Data up to Jan 2025

Published2006
Citations107
References66

Total Citations Per Year

Abstract

References (66)

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses

2001 • 3,785 citations

The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

2003 • 3,746 citations

Neurotrophins as synaptic modulators

2001 • 1,773 citations

Regulation of Cell Survival by Secreted Proneurotrophins

2001 • 1,618 citations

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

1998 • 1,504 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

NEUROTROPHINS AND SYNAPTIC PLASTICITY

1999 • 1,343 citations

The yin and yang of neurotrophin action

2005 • 1,279 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

2003 • 1,212 citations

BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis

2005 • 1,155 citations

Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport

1997 • 1,093 citations

Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

2004 • 1,084 citations

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

2004 • 862 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Neurotrophin secretion: current facts and future prospects

2003 • 648 citations

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis

1991 • 636 citations

Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons.

1991 • 578 citations

Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor

2001 • 538 citations

Depolarization and cAMP Elevation Rapidly Recruit TrkB to the Plasma Membrane of CNS Neurons

1998 • 521 citations

Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses

2001 • 508 citations

Transport, capture and exocytosis of single synaptic vesicles at active zones

2000 • 464 citations

Transport, docking and exocytosis of single secretory granules in live chromaffin cells

1997 • 437 citations

Cellular Mechanisms Regulating Activity-Dependent Release of Native Brain-Derived Neurotrophic Factor from Hippocampal Neurons

2002 • 400 citations

BDNF Regulates the Translation of a Select Group of mRNAs by a Mammalian Target of Rapamycin-Phosphatidylinositol 3-Kinase-Dependent Pathway during Neuronal Development

2004 • 399 citations

Activity-Dependent Transfer of Brain-Derived Neurotrophic Factor to Postsynaptic Neurons

2001 • 366 citations

Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.

1996 • 350 citations

Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons

1999 • 335 citations

Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons

1997 • 333 citations

Activity-Dependent Release of Endogenous Brain-Derived Neurotrophic Factor from Primary Sensory Neurons Detected by ELISAIn Situ

2000 • 333 citations

Gene Expression Profiling of Facilitated L-LTP in VP16-CREB Mice Reveals that BDNF Is Critical for the Maintenance of LTP and Its Synaptic Capture

2005 • 323 citations

Characterization of Nerve Growth Factor (NGF) Release from Hippocampal Neurons: Evidence for a Constitutive and an Unconventional Sodium‐dependent Regulated Pathway

1995 • 319 citations

Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF

2004 • 318 citations

Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system

1996 • 284 citations

Neurotrophin release by neurotrophins: Implications for activity-dependent neuronal plasticity

1997 • 268 citations

Neurotrophins and activity-dependent plasticity

2000 • 257 citations

Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor

2004 • 246 citations

Relative Contribution of Endogenous Neurotrophins in Hippocampal Long-Term Potentiation

1999 • 242 citations

Neurotrophin secretion from hippocampal neurons evoked by long-term-potentiation-inducing electrical stimulation patterns

2002 • 192 citations

Activity- and Ca2+-Dependent Modulation of Surface Expression of Brain-Derived Neurotrophic Factor Receptors in Hippocampal Neurons

2000 • 178 citations

Down-regulation of the Neurotrophin Receptor TrkB following Ligand Binding

2000 • 160 citations

Are Neurotrophins Synaptotrophins?

1996 • 134 citations

Simultaneous evanescent wave imaging of insulin vesicle membrane and cargo during a single exocytotic event

2000 • 132 citations

Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity

1999 • 130 citations

It's green outside: tracking cell surface proteins with pH-sensitive GFP

2004 • 130 citations

Neurotrophins induce release of neurotrophins by the regulated secretory pathway

1998 • 124 citations

Brain-derived neurotrophic factor is an anterograde survival factor in the rat visual system

2000 • 123 citations

Neurotrophin release by neurotrophins: Implications fro activity dependent neurons.

1997 • 106 citations

Nitric oxide down-regulates brain-derived neurotrophic factor secretion in cultured hippocampal neurons

2002 • 102 citations

A Cell-Free System for Regulated Exocytosis in Pc12 Cells

2000 • 102 citations

Acute and long-term synaptic modulation by neurotrophins

2004 • 101 citations

Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways

2001 • 101 citations

Axonal transport and neuronal transcytosis of trophic factors, tracers, and pathogens

2003 • 100 citations

Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx

2003 • 99 citations

Sorting of Internalized Neurotrophins into an Endocytic Transcytosis Pathway via the Golgi System: Ultrastructural Analysis in Retinal Ganglion Cells

2001 • 83 citations

Localized Synaptic Actions of Neurotrophin-4

1998 • 71 citations

Mechanisms of neurotrophin receptor vesicular transport

2003 • 69 citations

Mechanisms of the Release of Anterogradely Transported Neurotrophin-3 from Axon Terminals

2002 • 60 citations

Provision of Brain-Derived Neurotrophic Factor via Anterograde Transport from the Eye Preserves the Physiological Responses of Axotomized Geniculate Neurons

2003 • 52 citations

Regulated delivery of AMPA receptor subunits to the presynaptic membrane

2003 • 48 citations

Anterograde axonal transport of BDNF and NT-3 by retinal ganglion cells: Roles of neurotrophin receptors

2005 • 40 citations

Spatially Restricted Actions of BDNF

2002 • 32 citations

Prolonged recycling of internalized neurotrophins in the nerve terminal

2001 • 29 citations

Cell-specific expression of the epm1 (cystatin B) gene in developing rat cerebellum

2005 • 27 citations

Cited By (0)

Loading...