Activation of CPP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function.

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

1990 • 1,390 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Quantitative Nitroblue Tetrazolium Test in Chronic Granulomatous Disease

1968 • 894 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

1995 • 599 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

1982 • 349 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1993 • 272 citations

Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor

1993 • 253 citations

Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.

1995 • 222 citations

Pro‐oxidants and mitochondrial Ca²⁺: their relationship to apoptosis and oncogenesis

1993 • 218 citations

Ethidium Bromide-Induced Loss of Mitochondrial DNA from Primary Chicken Embryo Fibroblasts

1985 • 183 citations

Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity.

1993 • 163 citations

Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-α-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain

1995 • 160 citations

Possible requirement of internalization in the mechanism of in vitro cytotoxicity in tumor necrosis serum.

1981 • 160 citations

Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblasts.

1985 • 138 citations

Platelet-mediated transformation of mtDNA-less human cells: analysis of phenotypic variability among clones from normal individuals--and complementation behavior of the tRNALys mutation causing myoclonic epilepsy and ragged red fibers.

1994 • 126 citations

Apoptotic cell death induced by intracellular proteolysis.

1994 • 124 citations

Involvement of phospholipase A2 activation in tumour cell killing by tumour necrosis factor.

1988 • 124 citations

Differential roles of two types of the TNF receptor in TNF-induced cytotoxicity, DNA fragmentation, and differentiation.

1994 • 106 citations

Protection from tumor necrosis factor cytotoxicity by protease inhibitors

1987 • 75 citations

Involvement of a serine protease in tumour‐necrosis‐factor‐mediated cytotoxicity

1988 • 65 citations

Anti-tumour cytotoxin produced by human monocytes: Studies on its mode of action

1983 • 64 citations

Protease inhibitors differentially regulate tumor necrosis factor- induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation

1995 • 61 citations

Enhancement of CPP32-like Activity in the TNF-Treated U937 Cells by the Proteasome Inhibitors

1996 • 58 citations

Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.

1991 • 51 citations

Activation of Membrane Phospholipase a by Guinea Pig Lymphotoxin (GLT)

1979 • 31 citations

Characterization of the apoptotic effects of human tumor necrosis factor: development of highly rapid and specific bioassay for human tumor necrosis factor and lymphotoxin using human target cells

1995 • 22 citations

Damage to Mitochondrial Respiration Chain Is Related to Phospholipase A2 Activation Caused by Tumor Necrosis Factor

1992 • 17 citations

Purification and characterization of a cytotoxic factor produced by a mouse macrophage hybridoma

1985 • 15 citations