Role of the unfolded protein response in cell death

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 • 2,663 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

ER stress and the unfolded protein response

2004 • 1,696 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

A trip to the ER: coping with stress

2003 • 1,330 citations

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

2002 • 1,296 citations

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

2001 • 1,283 citations

Coupling endoplasmic reticulum stress to the cell death program

2004 • 1,172 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress

2001 • 832 citations

Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.

2002 • 821 citations

Calcium and oxidative stress: from cell signaling to cell death

2002 • 803 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein

2000 • 778 citations

CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells

2004 • 769 citations

Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors

2003 • 682 citations

A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response

2003 • 670 citations

Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

2002 • 658 citations

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

2003 • 586 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

Proteasome Inhibition As a Novel Therapeutic Target in Human Cancer

2005 • 574 citations

Signaling the Unfolded Protein Response from the Endoplasmic Reticulum

2004 • 572 citations

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

2002 • 560 citations

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

2000 • 551 citations

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies

2003 • 529 citations

Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

2003 • 507 citations

Cell death regulation by the Bcl‐2 protein family in the mitochondria

2003 • 493 citations

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

2000 • 485 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2002 • 480 citations

Caspase‐12 and ER‐Stress‐Mediated Apoptosis

2003 • 475 citations

Calcium and apoptosis: facts and hypotheses

2003 • 471 citations

A novel ER α‐mannosidase‐like protein accelerates ER‐associated degradation

2001 • 459 citations

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)–ATF composite site to regulate Gadd153 expression during the stress response

1999 • 445 citations

Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress

2004 • 427 citations

Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis-Acting Elements ERSE, UPRE and ERSE-II

2004 • 421 citations

Bcl-2 decreases the free Ca ²⁺ concentration within the endoplasmic reticulum

2000 • 417 citations

The proteasome as a target for cancer therapy.

2003 • 406 citations

Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation

2004 • 397 citations

Increased sensitivity to dextran sodium sulfate colitis in IRE1β-deficient mice

2001 • 390 citations

eIF2 and the control of cell physiology

2004 • 372 citations

Methamphetamine induces neuronal apoptosis via cross‐talks between endoplasmic reticulum and mitochondria‐dependent death cascades

2004 • 269 citations

The Unfolded Protein Response Modulates Disease Severity in Pelizaeus-Merzbacher Disease

2002 • 266 citations

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

2000 • 260 citations

Activation Signal of Nuclear Factor-.KAPPA.B in Response to Endoplasmic Reticulum Stress is Transduced via IRE1 and Tumor Necrosis Factor Receptor-Associated Factor 2

2003 • 249 citations

Effect on Tumor Cells of Blocking Survival Response to Glucose Deprivation

2004 • 211 citations

Protein-tyrosine Phosphatase 1B Potentiates IRE1 Signaling during Endoplasmic Reticulum Stress

2004 • 204 citations

Bax-mediated Ca2+ Mobilization Promotes Cytochrome c Release during Apoptosis

2002 • 199 citations

ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation

2003 • 190 citations

Clinical update: proteasome inhibitors in solid tumors

2003 • 161 citations

BH-3-only BIK Functions at the Endoplasmic Reticulum to Stimulate Cytochrome c Release from Mitochondria

2002 • 152 citations

Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions

2003 • 152 citations

Analysis of Cyclooxygenase 2 (COX-2) Expression During Malignant Melanoma Progression

2003 • 139 citations

The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts

2004 • 134 citations

Rationale for the treatment of solid tumors with the proteasome inhibitor bortezomib

2003 • 126 citations

Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?

2004 • 126 citations

Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2.

2003 • 123 citations

Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members

2003 • 123 citations

The Protein Kinase/Endoribonuclease IRE1α That Signals the Unfolded Protein Response Has a Luminal N-terminal Ligand-independent Dimerization Domain

2002 • 122 citations

Modulation of Mitochondrial Ca2+ Homeostasis by Bcl-2

1999 • 112 citations

Repression of GADD153/CHOP by NF-κB: a possible cellular defense against endoplasmic reticulum stress-induced cell death

2001 • 106 citations

Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis

2002 • 98 citations

The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo

2004 • 80 citations

Apoptosis And Calcium: New Roles For Cytochrome c and Inositol 1,4,5-trisphosphate

2004 • 78 citations

GADD153-mediated Anticancer Effects of N-(4-Hydroxyphenyl)retinamide on Human Hepatoma Cells

2002 • 78 citations

Endoplasmic reticulum stress triggers an acute proteasome‐dependent degradation of ATF6

2004 • 77 citations

Intracellular calcium release is required for caspase‐3 and ‐9 activation

2003 • 62 citations

Gene Expression Changes Associated with the Endoplasmic Reticulum Stress Response Induced by Microsomal Cytochrome P450 Overproduction

2004 • 56 citations

Endoplasmic reticulum-associated degradation: exceptions to the rule

2004 • 52 citations

Selective activation of the c-Jun N-terminal kinase (JNK) pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3′-kinase (PI3K) pathway is inhibited

2003 • 49 citations

Expression of stress response protein glucose regulated protein-78 mediated by c-Myb

2005 • 33 citations

Proteasomal Degradation of Topoisomerase I Is Preceded by c-Jun NH2-Terminal Kinase Activation, Fas Up-Regulation, and Poly(ADP-Ribose) Polymerase Cleavage in SN38-Mediated Cytotoxicity against Multiple Myeloma

2004 • 32 citations

Release of mitochondrial Ca ²⁺ via the permeability transition activates endoplasmic reticulum Ca ²⁺ uptake

2002 • 31 citations

Introduction of gadd153 gene into gastric cancer cells can modulate sensitivity to anticancer agents in association with apoptosis.

1999 • 28 citations

The physiological unfolded protein response in the thyroid epithelial cells

2004 • 24 citations

Taxotere activates transcription factor AP-1 in association with apoptotic cell death in gastric cancer cell lines.

2000 • 20 citations

Rapid Induction of the Grp78 Gene by Cooperative Actions of Okadaic Acid and Heat‐Shock in 9L Rat Brain Tumor Cells

1997 • 19 citations