Rapid Induction of the Grp78 Gene by Cooperative Actions of Okadaic Acid and Heat‐Shock in 9L Rat Brain Tumor Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 • 1,292 citations

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1993 • 1,197 citations

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1990 • 391 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains

1994 • 256 citations

Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2

1992 • 255 citations

Complex regulation of heat shock- and glucose-responsive genes in human cells.

1988 • 242 citations

Transactivation of the grp78 promoter by Ca2+ depletion. A comparative analysis with A23187 and the endoplasmic reticulum Ca(2+)-ATPase inhibitor thapsigargin

1993 • 228 citations

Identity of the immunoglobulin heavy-chain-binding protein with the 78,000-dalton glucose-regulated protein and the role of posttranslational modifications in its binding function.

1988 • 211 citations

Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins.

1992 • 173 citations

The 9L rat brain tumor: Description and application of an animal model

1981 • 166 citations

Inhibition of protein synthesis and early protein processing by thapsigargin in cultured cells

1993 • 157 citations

Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.

1993 • 137 citations

Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-α gene

1994 • 125 citations

Ischemia and Reperfusion Enhance ATF-2 and c-Jun Binding to cAMP Response Elements and to an AP-1 Binding Site from the c-jun Promoter

1995 • 118 citations

Calcium ionophore A23187 as a regulator of gene expression in mammalian cells.

1986 • 109 citations

Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases.

1992 • 106 citations

Regulation of c-jun Expression during Hypoxic and Low-Glucose Stress

1994 • 104 citations

Adenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun.

1993 • 98 citations

Brefeldin A, thapsigargin, and AlF stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis

1992 • 98 citations

A short protocol for micro-purification of nuclear proteins from whole animal tissue.

1991 • 87 citations

Differential regulation of three members of the ATF/CREB family of DNA-binding proteins.

1991 • 82 citations

Regulation of c-jun expression during hypoxic and low-glucose stress.

1994 • 79 citations

cAMP and cAMP-dependent protein kinase regulate the human heat shock protein 70 gene promoter activity

1991 • 78 citations

Brefeldin A as a regulator of grp78 gene expression in mammalian cells.

1992 • 71 citations

Common sets of nuclear factors binding to the conserved promoter sequence motif of two coordinately regulated ER protein genes,GRP78andGRP94

1991 • 69 citations

Requirement of Tyrosine- and Serine/Threonine Kinases in the Transcriptional Activation of the Mammalian grp78/BiP Promoter by Thapsigargin

1995 • 57 citations

Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor-beta 2 promoter.

1992 • 55 citations

Interaction of Ethanol with Inducers of Glucose-regulated Stress Proteins

1996 • 52 citations

Structural determinants outside of the leucine zipper influence the interactions of CREB and ATF-2: interaction of CREB with ATF-2 blocks E1a-ATF-2 complex formation.

1993 • 47 citations

Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases

1992 • 45 citations

The Regulation of GRP78 and Messenger RNA Levels by Hypoxia Is Modulated by Protein Kinase C Activators and Inhibitors

1994 • 43 citations

A Binding Site for the Cyclic Adenosine 3′,5′-Monophosphate-Response Element-Binding Protein as a Regulatory Element in the grp78 Promoter

1991 • 42 citations

Okadaic acid markedly potentiates the heat-induced hsp 70 promoter activity.

1993 • 39 citations

The human retinoblastoma susceptibility gene promoter is positively autoregulated by its own product.

1994 • 38 citations

Induction of HSP70 is associated with vincristine resistance in heat-shocked 9L rat brain tumour cells

1992 • 37 citations

Vimentin serves as a phosphate sink during the apparent activation of protein kinases by okadaic acid in mammalian cells

1993 • 36 citations

Heat‐induced transcription from RNA polymerases II and III and HSF binding activity are co‐ordinately regulated by the products of the heat shock genes

1992 • 30 citations

Stimulation of GRP78 gene transcription by phorbol ester and cAMP in GH3 pituitary cells. The accommodation of protein synthesis to chronic deprivation of intracellular sequestered calcium.

1991 • 23 citations

Thyrotropin Stimulates Glucose-Regulated Protein (GRP78) Gene Expression in Rat Functional Thyroid Epithelial Cells, FRTL

1991 • 17 citations

Transcriptional Regulation of the Gene Encoding the 78-kD Glucose-Regulated Protein GRP78 in Mouse Sertoli Cells: Binding of Specific Factor(s) to the GRP78 Promoter

1989 • 15 citations

Okadaic acid as an inducer of the 78‐kDa glucose‐regulated protein in 9L rat brain tumor cells

1993 • 14 citations

Modulation of protein phosphorylation and stress protein expression by okadaic acid on heat shock cells

1996 • 10 citations

Oncogenes, breast cancer, and chemoprevention

1993 • 7 citations