Functional Analysis of Asb-1 Using Genetic Modification in Mice

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

Twenty proteins containing a C-terminal SOCS box form five structural classes

1998 • 735 citations

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1999 • 620 citations

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1998 • 596 citations

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

1996 • 589 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

Hundreds of ankyrin‐like repeats in functionally diverse proteins: Mobile modules that cross phyla horizontally?

1993 • 504 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1

1998 • 433 citations

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin

1998 • 389 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

The Human Ubiquitin C Promoter Directs High Ubiquitous Expression of Transgenes in Mice

1996 • 203 citations

Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK

1995 • 162 citations

Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity.

1995 • 154 citations

Negative Regulators of Cytokine Signaling

2001 • 106 citations

Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ “knock-in” strategy

1998 • 87 citations

Role of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in the development of an acute neutrophil inflammatory response in mice

1996 • 81 citations

Myeloid Stem Cell Kinetics during Erythropoietic Stress

1971 • 53 citations

Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4

2000 • 48 citations

Cellular and molecular basis of the increased splenic hemopoiesis in mice treated with bacterial cell wall components.

1980 • 32 citations