THE NEWER MACROLIDES: AZITHROMYCIN AND CLARITHROMYCIN

The Effect of Changes in the Consumption of Macrolide Antibiotics on Erythromycin Resistance in Group A Streptococci in Finland

1997 • 1,221 citations

Community‐Acquired Pneumonia in Adults: Guidelines for Management

1998 • 862 citations

The pharmacokinetics of azithromycin in human serum and tissues

1990 • 759 citations

Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification

1991 • 605 citations

Lack of Effect of TreatingHelicobacter pyloriInfection in Patients with Nonulcer Dyspepsia

1998 • 524 citations

Current Clinical Topics in Infectious Diseases

1984 • 494 citations

1998 Guidelines for Treatment of Sexually Transmitted Diseases

1997 • 486 citations

In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection

1989 • 484 citations

Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms

1987 • 459 citations

Guidelines for the management of Helicobacter pylori infection

1998 • 417 citations

Resistance to Erythromycin in Group A Streptococci

1992 • 361 citations

Absence of Benefit of EradicatingHelicobacter pyloriin Patients with Nonulcer Dyspepsia

1999 • 361 citations

Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum, Mycobacterium chelonae, and M. chelonae-like organisms

1992 • 313 citations

Azithromycin

1992 • 294 citations

Clarithromycin

1992 • 285 citations

Surveillance of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States in 1996–1997 respiratory season

1997 • 281 citations

Medical Treatment of Peptic Ulcer Disease

1996 • 261 citations

Clinical Trial of Clarithromycin for Cutaneous (Disseminated) Infection due to Mycobacterium chelonae

1993 • 248 citations

Consensus conference. Medical treatment of peptic ulcer disease. Practice guidelines. Practice Parameters Committee of the American College of Gastroenterology

1996 • 244 citations

Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria

1991 • 221 citations

Clinical toleration and safety of azithromycin

1991 • 220 citations

Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial.

1993 • 216 citations

Mycobacterium avium Complex Infection and AIDS: Advances in Theory and Practice

1993 • 206 citations

Azithromycin for treatment of Mycobacterium avium-intracellulare complex infection in patients with AIDS

1991 • 196 citations

Initial clarithromycin monotherapy for Mycobacterium avium-intracellulare complex lung disease.

1994 • 191 citations

Intrapulmonary steady-state concentrations of clarithromycin and azithromycin in healthy adult volunteers

1997 • 190 citations

Clarithromycin and azithromycin: new macrolide antibiotics.

1992 • 188 citations

Eradication of Helicobacter pylori with clarithromycin and omeprazole.

1994 • 179 citations

Macrolides with gastrointestinal motor stimulating activity

1987 • 176 citations

Activity of clarithromycin against Mycobacterium avium infection in patients with the acquired immune deficiency syndrome

1991 • 170 citations

An evaluation of the susceptibility patterns of Gram-negative organisms isolated in cancer centres with aminoglycoside usage

1991 • 165 citations

In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide

1986 • 164 citations

Azithromycin

1996 • 151 citations

Multicenter Trial of Single-Dose Azithromycin vs. Ceftriaxone in the Treatment of Uncomplicated Gonorrhea

1994 • 147 citations

Enhancement of the in vitro and in vivo activities of clarithromycin against Haemophilus influenzae by 14-hydroxy-clarithromycin, its major metabolite in humans

1990 • 143 citations

Activities of clarithromycin against eight slowly growing species of nontuberculous mycobacteria, determined by using a broth microdilution MIC system

1992 • 130 citations

Metabolism and disposition of clarithromycin in man.

1990 • 129 citations

The development of macrolides: clarithromycin in perspective

1991 • 126 citations

Azithromycin: The First Azalide Antibiotic

1992 • 123 citations

Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily.

1997 • 120 citations

Ranitidine bismuth citrate plus clarithromycin is effective for healing duodenal ulcers, eradicating H. pylori and reducing ulcer recurrence. RBC H. pylori Study Group [see comments]

1996 • 119 citations

Clarithromycin, a unique macrolide

1992 • 119 citations

The diffusion of clarithromycin and roxithromycin into nasal mucosa, tonsil and lung in humans

1991 • 106 citations

Pyrimethamine-clarithromycin combination for therapy of acute Toxoplasma encephalitis in patients with AIDS

1991 • 105 citations

Macrolides Versus Azalides: A Drug Interaction Update

1995 • 104 citations

Azithromycin versus doxycycline for treatment of erythema migrans: Clinical and microbiological findings

1993 • 102 citations

Comparison of azithromycin and erythromycin in the treatment of atypical pneumonias

1990 • 100 citations

Azithromycin and Clarithromycin Overview and Comparison With Erythromycin

1992 • 99 citations

Clarithromycin: Review of a New Macrolide Antibiotic with Improved Microbiologic Spectrum and Favorable Pharmacokinetic and Adverse Effect Profiles

1992 • 98 citations

Powerful Bactericidal Activities of Clarithromycin and Minocycline against Mycobacterium leprae in Lepromatous Leprosy

1993 • 91 citations

Medical Treatment of Peptic Ulcer Disease

1991 • 90 citations

Treatment of Community-acquired Pneumonia

1993 • 90 citations

Randomized, Multicentre Study of the Efficacy and Tolerance of Azithromycin versus Clarithromycin in the Treatment of Adults with Mild to Moderate Community-Acquired Pneumonia

1998 • 87 citations

Overview of the Tolerability Profile of Clarithromycin in Preclinical and Clinical Trials

1993 • 85 citations

Comparative studies of azithromycin in skin and soft-tissue infections and sexually transmitted infections by Neisseria and Chlamydia species

1990 • 84 citations

Clarithromycin

1997 • 82 citations

Azithromycin and doxycycline for treatment ofBorrelia culture-positive erythema migrans

1996 • 82 citations

Drug interactions with azithromycin and the macrolides: an overview

1996 • 81 citations

Comparative Tolerability of Erythromycin and Newer Macrolide Antibacterials in Paediatric Patients

1999 • 79 citations

Azithromycin versus cefaclor in the treatment of acute bacterial pneumonia

1991 • 79 citations

Clarithromycin for the Eradication of Helicobacter Pylori

1993 • 74 citations

A Comparison of 10 and 14 Days of Lansoprazole Triple Therapy for Eradication of Helicobacter pylori

1998 • 73 citations

Correlation of the extravascular pharmacokinetics of azithromycin with in-vivo efficacy in models of localized infection

1990 • 72 citations

Azithromycin and clarithromycin

1995 • 68 citations

Comparison of azithromycin versus clarithromycin in the treatment of patients with lower respiratory tract infection

1993 • 67 citations

Erythema migrans: comparison of treatment with azithromycin, doxycycline and phenoxymethylpenicillin

1992 • 64 citations

Open study of the safety and efficacy of a single oral dose of azithromycin for the treatment of uncomplicated gonorrhoea in men and women

1993 • 60 citations

The absence of an effect of food on the bioavailability of azithromycin administered as tablets, sachet or suspension

1996 • 58 citations

Multiple mechanisms of erythromycin resistance

1990 • 58 citations

Clarithromycin-ciprofloxacin-amikacin for therapy of Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS

1992 • 58 citations

Azithromycin compared with cephalexin in the treatment of skin and skin structure infections

1991 • 54 citations

Azithromycin and erythromycin in the treatment of cervical chlamydial infection during pregnancy.

1994 • 54 citations

A Multicenter, Investigator‐Blinded, Randomized Comparison of Oral Levofloxacin and Oral Clarithromycin in the Treatment of Acute Bacterial Sinusitis

1998 • 52 citations

Comparison of azithromycin versus clarithromycin in the treatment of patients with upper respiratory tract infections

1993 • 52 citations

Phannacokinetics of azithromycin in patients with impaired hepatic function

1993 • 51 citations

Pyrimethamine plus azithromycin for treatment of acute toxoplasmic encephalitis in patients with AIDS

1993 • 51 citations

Clinical trial of clarithromycin for lepromatous leprosy

1994 • 50 citations

The Safety and Efficacy of Clarithromycin in Patients with Legionella Pneumonia

1991 • 49 citations

Efficacy and Safety of Clarithromycin Compared to Cefixime as Outpatient Treatment of Lower Respiratory Tract Infections

1993 • 46 citations

Azithromycin in the treatment of uncomplicated genital chlamydial infections

1991 • 45 citations

Comparison of azithromycin and doxycycline in the treatment of non-gonococcal urethritis in men

1993 • 43 citations

Single-dose oral azithromycin versus seven-day doxycycline in the treatment of non-gonococcal urethritis in males

1993 • 42 citations

Intravenous Azithromycin

1999 • 41 citations

Double-Blind Comparative Trial of Ciprofloxacin versus Clarithromycin in the Treatment of Acute Bacterial Sinusitis

1999 • 35 citations

Helicobacter pylori: rational management options

1998 • 35 citations

Clarithromycin in treatment of early Lyme disease: a pilot study

1996 • 35 citations

Clarithromycin and Omeprazole

1996 • 34 citations

The efficacy and tolerance of a three-day course of azithromycin in the treatment of community-acquired pneumonia

1993 • 33 citations

Azithromycin versus amoxicillin/clavulanate in the treatment of acute sinusitis

1999 • 33 citations

The role of azalide antibiotics in the treatment of chlamydia

1991 • 32 citations

Effect of Moderate or Severe Hepatic Impairment on Clarithromycin Pharmacokinetics

1993 • 32 citations

A Comparison of the Efficacy, Tolerability and Safety of Azithromycin and Co-Amoxiclav in the Treatment of Sinusitis in Adults

1998 • 31 citations

Effectiveness of the macrolide clarithromycin in the treatment ofMycobacterium avium complex infection in HIV-infected patients

1992 • 30 citations

Introduction: Revolutionary changes in the macrolide and azalide antibiotics

1991 • 30 citations

Cefuroxime axetil versus clarithromycin in the treatment of acute maxillary sinusitis.

1998 • 26 citations

Azithromycin and clarithromycin.

1994 • 25 citations

Short report: clarithromycin, an alternative to metronidazole in the triple therapy of Helicobacter pylori infection

1994 • 25 citations

Double‐blind, Multicenter, Placebo‐Controlled Evaluation Of Clarithromycin And Omeprazole For Helicobacter Pylori‐Associated Duodenal Ulcer

1996 • 25 citations

Optimal duration of therapy combining ranitidine bismuth citrate with clarithromycin and metronidazole in the eradication of Helicobacter pylori infection

1999 • 23 citations

Comparison of sparfloxacin and clarithromycin in the treatment of acute bacterial maxillary sinusitis

1999 • 22 citations

Review and Comparison of Advanced‐Generation Macrolides Clarithromycin and Dirithromycin

1999 • 22 citations

Two Cases of Clarithromycin‐Induced Digoxin Toxicity

1997 • 21 citations

Antimicrobial Activities and Postantibiotic Effects of Clarithromycin, 14-Hydroxy-Clarithromycin, and Azithromycin in Epithelial Cell Lining Fluid against Clinical Isolates of Haemophilus influenzae and Streptococcus pneumoniae

1999 • 20 citations

Interpretative criteria for the agar diffusion susceptibility test with azithromycin

1988 • 19 citations

Clarithromycin 250 mg b. i. d. for 5 or 10 days in the treatment of adult patients with purulent bronchitis

1993 • 14 citations

Efficacy of a 1‐week regimen of ranitidine bismuth citrate in combination with metronidazole and clarithromycin for Helicobacter pylori eradication

1999 • 14 citations

Regression analysis, proposed interpretative zone size standards, and quality control guidelines for a new macrolide antimicrobial agent, A-56268 (TE-031)

1987 • 13 citations

Introduction

1993 • 4 citations