Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily.

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

1996 • 598 citations

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

1994 • 390 citations

Pharmacokinetic Drug Interactions of Macrolides

1992 • 355 citations

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

1996 • 342 citations

Evaluation of Triacetyloleandomycin, α-Nasymphthoflavone and Diethyldithiocarbamate as Selective Chemical Probes for Inhibition of Human Cytochromes P450

1994 • 252 citations

Clarithromycin and azithromycin: new macrolide antibiotics.

1992 • 188 citations

Reduced Serum Levels Of Clarithromycin In Patients Treated With Multi-Drug Regimens Including Rifampin Or Rifabutin For Mycobacterium Avium-M. Intracellulare Infection

1995 • 180 citations

Pharmacokinetic Interactions of the Macrolide Antibiotics

1985 • 142 citations

Effect of omeprazole on concentrations of clarithromycin in plasma and gastric tissue at steady state

1995 • 135 citations

Metabolism and disposition of clarithromycin in man.

1990 • 129 citations

Dual effects of macrolide antibiotics on rat liver cytochrome P-450

1983 • 116 citations

Clarithromycin Clinical Pharmacokinetics

1993 • 102 citations

Clarithromycin: Review of a New Macrolide Antibiotic with Improved Microbiologic Spectrum and Favorable Pharmacokinetic and Adverse Effect Profiles

1992 • 98 citations

Comparison of the Effect of the Macrolide Antibiotics Erythromycin, Clarithromycin and Azithromycin on Terfenadine Steady-State Pharmacokinetics and Electrocardiographic Parameters

1994 • 93 citations

cDNA-directed expression of human cytochrome P450 CYP3A4 using baculovirus.

1994 • 83 citations

Effects of clarithromycin on cytochrome P-450. Comparison with other macrolides.

1989 • 81 citations

Measurement of Liver Microsomal Cytochrome P450 (CYP2D6) Activity Using [O-methyl-14C] Dextromethorphan

1994 • 77 citations

In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices.

1995 • 69 citations

Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells

1994 • 67 citations

Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers

1993 • 64 citations

Single‐ and Multiple‐dose Pharmacokinetics of Clarithromycin, a New Macrolide Antimicrobial

1993 • 64 citations

[O-methyl 14C]naproxen O-demethylase activity in human liver microsomes: evidence for the involvement of cytochrome P4501A2 and P4502C9/10.

1996 • 60 citations

Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro

1994 • 48 citations

Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193.

1995 • 43 citations

Clarithromycin and Omeprazole

1996 • 34 citations

Erythromycin as a specific substrate for cytochrome P4503A isozymes and identification of a high-affinity erythromycin N-demethylase in adult female rats.

1996 • 31 citations

Possible Role of the Intestinal P‐450 Enzyme System in a Cyclosporine‐Clarithromycin Interaction

1996 • 27 citations

Assessment of the Pharmacokinetic Interaction Between Ritonavir (R) and Clarithromycin (C)

1996 • 22 citations

STRANGULATED UMBILICAL HERNIA

1875 • 1 citations