Medical Treatment of Peptic Ulcer Disease

Helicobacter pylori in peptic ulcer disease.

2004 • 1,308 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs

1995 • 1,071 citations

PROSPECTIVE DOUBLE-BLIND TRIAL OF DUODENAL ULCER RELAPSE AFTER ERADICATION OF CAMPYLOBACTER PYLORI

1988 • 1,051 citations

Epidemiology of Helicobacter pylori in an asymptomatic population in the United States

1991 • 970 citations

Cure of duodenal ulcer associated with eradication of Helicobacter pylori

1990 • 943 citations

Effect of Treatment of Helicobacter pylori Infection on the Long-term Recurrence of Gastric or Duodenal Ulcer

1992 • 924 citations

Basic and clinical aspects of visceral hyperalgesia

1994 • 916 citations

Campylobacter pylori and Peptic Ulcer Disease

1989 • 760 citations

Effect of Ranitidine and Amoxicillin plus Metronidazole on the Eradication of Helicobacter pylori and the Recurrence of Duodenal Ulcer

1993 • 729 citations

Helicobacter pylori and the Pathogenesis of Gastroduodenal Inflammation

1990 • 688 citations

PREVENTION OF NSAID-INDUCED GASTRIC ULCER WITH MISOPROSTOL: MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

1988 • 615 citations

Corticosteroid Use and Peptic Ulcer Disease: Role of Nonsteroidal Anti-inflammatory Drugs

1991 • 606 citations

Factors influencing the eradication of Helicobacter pylori with triple therapy

1992 • 558 citations

CAMPYLOBACTER PYLORI AND RECURRENCE OF DUODENAL ULCERS— A 12-MONTH FOLLOW-UP STUDY

1987 • 555 citations

Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection

1995 • 550 citations

Nonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Disease

1991 • 402 citations

Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa

1980 • 401 citations

Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine.

1988 • 388 citations

Diagnostic value of decreasing IgG, IgA, and IgM antibody titres after eradication of Helicobacter pylori

1992 • 387 citations

Effect of Omeprazole and Ranitidine on Ulcer Healing and Relapse Rates in Patients with Benign Gastric Ulcer

1989 • 382 citations

Nonsteroidal anti-inflammatory drug-associated gastropathy: Incidence and risk factor models

1991 • 364 citations

Is there an optimal degree of acid suppression for healing of duodenal ulcers?

1990 • 351 citations

Concurrent Use of Nonsteroidal Anti-inflammatory Drugs and Oral Anticoagulants Places Elderly Persons at High Risk for Hemorrhagic Peptic Ulcer Disease

1993 • 321 citations

Duodenal and Gastric Ulcer Prevention with Misoprostol in Arthritis Patients Taking NSAIDs

1993 • 300 citations

Antibacterial Treatment of Gastric Ulcers Associated withHelicobacter pylori

1995 • 276 citations

Duodenal ulcer healing by eradication of Helicobacter pylori without anti-acid treatment: randomised controlled trial

1994 • 270 citations

Treatment of Helicobacter pylori Reduces the Rate of Rebleeding in Peptic Ulcer Disease

1993 • 270 citations

A critique of therapeutic trials in Helicobacter pylori-positive functional dyspepsia

1994 • 260 citations

Empirical H2-blocker therapy or prompt endoscopy in management of dyspepsia

1994 • 259 citations

Effect of ranitidine gastroduodenal mucosal damage induced by nonsteroidal antiinflammatory drugs

1989 • 244 citations

Eradication of Helicobacter pylori reduces the possibility of rebleeding in peptic ulcer disease

1995 • 242 citations

Simultaneous visualization of Helicobacter pylori and gastric morphology: A new stain

1994 • 241 citations

Effect of acid suppression on efficacy of treatment for Helicobacter pylori infection

1995 • 234 citations

Effect of Triple Therapy (Antibiotics plus Bismuth) on Duodenal Ulcer Healing

1991 • 222 citations

Double-Contrast Barium Meal and Upper Gastrointestinal Endoscopy

1984 • 207 citations

Helicobacter pylori eradication reduces the rate of rebleeding in ulcer hemorrhage

1995 • 202 citations

Alternative Management Strategies for Patients with Suspected Peptic Ulcer Disease

1995 • 193 citations

Long-term nonsteroidal antiinflammatory drug use and Helicobacter pylori infection

1991 • 181 citations

Ranitidine in the treatment of non-steroidal anti-inflammatory drug associated gastric and duodenal ulcers.

1991 • 149 citations

Prophylactic effect of cimetidine in duodenal ulcer disease.

1978 • 130 citations

The Effect of Chronic Aspirin Use on Duodenal and Gastric Ulcer Hospitalizations

1990 • 123 citations

High prevalence of Helicobacter pylori metronidazole resistance in migrants to east London: relation with previous nitroimidazole exposure and gastroduodenal disease.

1994 • 113 citations

A Controlled Study of Ranitidine for the Prevention of Recurrent Hemorrhage from Duodenal Ulcer

1994 • 110 citations

A Controlled Study Comparing the Effects of Nabumetone, Ibuprofen, and Ibuprofen Plus Misoprostol on the Upper Gastrointestinal Tract Mucosa

1993 • 106 citations

Randomized study comparing 1 with 2 weeks of quadruple therapy for eradicating Helicobacter pylori.

1994 • 103 citations

Campylobacter pylori and Its Role in Peptic Ulcer Disease

1990 • 94 citations

Drugs Five Years Later: Cimetidine: I. Developments, Pharmacology, and Efficacy

1982 • 93 citations

Metronidazole, omeprazole and clarithromycin: an effective combination therapy for Helicobacter pylori infection

1995 • 91 citations

Nonsteroidal antiinflammatory drug-associated gastric ulcers do not require Helicobacter pylori for their development.

1992 • 90 citations

The treatment of gastric ulcer with antisecretory drugs

1988 • 81 citations

Low dose, short-term triple therapy for cure of Helicobacter pylori infection and healing of peptic ulcers.

1995 • 77 citations

A Randomized Study of Maintenance Therapy with Ranitidine to Prevent the Recurrence of Duodenal Ulcer

1989 • 71 citations

Maintenance Treatment with Cimetidine in Peptic Ulcer Disease for Up to 4 Years

1987 • 70 citations

The Relationship Between Nonsteroidal Anti-inflammatory Drug Use and Peptic Ulcer Disease

1990 • 64 citations

Quadruple therapy compared with dual therapy for eradication of Helicobacter pylori in ulcer patients: results of a randomized prospective single-centre study

1995 • 62 citations

Duodenal Ulcer Healing with Four Antacid Tablets Daily

1985 • 61 citations

A multicenter, double-blind, randomized, placebo-controlled comparison of nocturnal and twice-a-day famotidine in the treatment of active duodenal ulcer disease

1987 • 54 citations

Cure of peptic gastric ulcer associated with eradication of Helicobacter pylori. Finnish Gastric Ulcer Study Group.

1995 • 52 citations

Omeprazole 20 mg three days a week and 10 mg daily in prevention of duodenal ulcer relapse

1991 • 48 citations

Treatment of refractory peptic ulcer with omeprazole or continued H2 receptor antagonists: a controlled clinical trial.

1991 • 43 citations

Helicobacter pyloriEradication with Doxycycline—Metronidazole—Bismuth Subcitrate Triple Therapy

1992 • 42 citations

Efficacy and Safety of Omeprazole in the Long-Term Treatment of Peptic Ulcer and Reflux Oesophagitis Resistant to Ranitidine

1990 • 42 citations

H2-receptor antagonists and duodenal ulcer recurrence: analysis of efficacy and commentary on safety, costs, and patient selection.

1987 • 39 citations

Pseudomembranous colitis following clarithromycin therapy.

1995 • 38 citations

Double blind multicentre comparison of omeprazole 20 mg once daily versus ranitidine 150 mg twice daily in the treatment of cimetidine or ranitidine resistant duodenal ulcers.

1989 • 38 citations

Gastric adenocarcinoma masquerading endoscopically as benign gastric ulcer

1988 • 35 citations

Prospective, randomized, investigator-blind trial ofHelicobacter pylori infection treatment in patients with refractory duodenal ulcers

1993 • 35 citations

The Efficacy of Endoscopy in the Evaluation of Dyspepsia

1986 • 35 citations

Clarithromycin‐amoxycillin therapy for Helicobacter pylori infection

1994 • 34 citations

Bismuth subsalicylate in the treatment of H2 blocker resistant duodenal ulcers: role of Helicobacter pylori.

1992 • 32 citations

Gastroduodenal mucosal damage with salsalate versus aspirin: Results of experimental models and endoscopic studies in humans

1990 • 32 citations

Cost-effectiveness of cimetidine maintenance therapy in chronic gastric and duodenal ulcer

1990 • 27 citations

Prevention of Duodenal Ulcer Recurrence

1986 • 25 citations

FIVE-YEAR STUDY OF CIMETIDINE OR SURGERY FOR SEVERE DUODENAL ULCER DYSPEPSIA

1982 • 25 citations

Duodenal and gastric ulcer healing rates: a review.

1984 • 25 citations

Effect of the pre-operative response to H2 receptor antagonists on the outcome of highly selective vagotomy for duodenal ulcer

1987 • 24 citations

Long Term Treatment of Duodenal Ulcer

1991 • 24 citations

Early and advanced gastric cancer during follow-up of apparently benign gastric ulcer: Significance of the presence of epithelial dysplasia

1987 • 23 citations

Is upper gastrointestinal radiography necessary in the initial management of uncomplicated dyspepsia?

1989 • 22 citations

Comparison of nizatidine and cimetidine as once-nightly treatment of acute duodenal ulcer. Nizatidine Multicenter Duodenal Ulcer Study Group.

1989 • 14 citations

Helicobacter pylori and refractory duodenal ulcers: cross-over comparison of continued cimetidine with cimetidine plus antimicrobials.

1994 • 9 citations

Gastric ulcers—When is enough enough?

1993 • 6 citations

Deleted Work

1955 • 0 citations