Mechanisms of limb patterning

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

1994 • 855 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse

1992 • 676 citations

FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

1993 • 660 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Vertebrate Limb and Somite Morphogenesis

1979 • 613 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development

1994 • 470 citations

Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb

1994 • 465 citations

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

1993 • 454 citations

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye

1993 • 423 citations

The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina

1993 • 414 citations

Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development

1991 • 410 citations

FGF-4 and BMP-2 have opposite effects on limb growth

1993 • 377 citations

A quantitative analysis of the effect of excision of the AER from the chick limb-bud

1974 • 376 citations

Homeobox gene expression correlated with the bifurcation process of limb cartilage development

1991 • 317 citations

Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations

1992 • 307 citations

What do BMPs do in mammals? Clues from the mouse short-ear mutation

1994 • 300 citations

Induction of floor plate differentiation by contact-dependent, homeogenetic signals

1993 • 271 citations

Homeotic transformations and limb defects in Hox A11 mutant mice.

1993 • 260 citations

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

1992 • 248 citations

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud

1991 • 218 citations

Drosophila hedgehog acts as a morphogen in cellular patterning

1994 • 215 citations

The number of polarizing region cells required to specify additional digits in the developing chick wing

1981 • 209 citations

Why we have (only) five fingers per hand: Hox genes and the evolution of paired limbs

1992 • 189 citations

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

1993 • 172 citations

FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro

1993 • 151 citations

Distribution of FGF‐2 suggests it has a role in chick limb bud growth

1993 • 144 citations

Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo

1993 • 112 citations

Interaction between limb bud ectoderm and mesoderm in the chick embryo. II. Experimental limb duplication

1956 • 96 citations

Retroviral expression of FGF-2 (bFGF) affects patterning in chick limb bud

1993 • 93 citations

Localization of HstI transcripts to the apical ectodermal ridge in the mouse embryo

1992 • 91 citations

Mitogenic property of the apical ectodermal ridge

1982 • 74 citations

FGF-4 regulates expression of Evx-1 in the developing mouse limb

1993 • 63 citations

Control of maintenance and anteroposterior skeletal differentiation of the anterior mesenchyme of the chick wing bud by its posterior margin (the ZPA)

1981 • 44 citations

The mis-expression of posterior Hox-4 genes in talpid (te3) mutant wings correlates with the absence of anteroposterior polarity

1992 • 41 citations

Maintenance of ZPA signaling in cultured mouse limb bud cells

1993 • 41 citations

The role of homeobox genes in limb development

1993 • 34 citations

Factoring in the limb

1993 • 12 citations