Microarrays as a Tool to Investigate the Biology of Aging: A Retrospective and a Look to the Future

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

Statistical significance for genomewide studies

2003 • 9,411 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

Pseudoreplication and the Design of Ecological Field Experiments

1984 • 8,087 citations

Minimum information about a microarray experiment (MIAME)—toward standards for microarray data

2001 • 4,058 citations

Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems

2002 • 2,534 citations

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

2003 • 2,209 citations

Gene regulation and DNA damage in the ageing human brain

2004 • 1,826 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

2002 • 1,150 citations

Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster

2002 • 567 citations

Comparing genomic expression patterns across species identifies shared transcriptional profile in aging

2004 • 446 citations

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

2001 • 386 citations

Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster

2004 • 371 citations

Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron

2002 • 348 citations

Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells?

2004 • 306 citations

Transcriptional Profile of Aging in C. elegans

2002 • 298 citations

Measurement of DNA oxidation in human cells by chromatographic and enzymic methods

2003 • 278 citations

The efficiency of pooling mRNA in microarray experiments

2003 • 261 citations

Aging: The Reality: Biomarkers of Aging: From Primitive Organisms to Humans

2004 • 196 citations

Production of Age-Synchronous Mass Cultures of Caenorhabditis elegans

1994 • 137 citations

Gene Expression Patterns in Calorically Restricted Mice: Partial Overlap with Long-Lived Mutant Mice

2002 • 119 citations

Interpretation, Design, and Analysis of Gene Array Expression Experiments

2001 • 103 citations

Microarray analysis of gene expression with age in individual nematodes

2004 • 99 citations

Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart

2003 • 98 citations

Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart

2003 • 87 citations

Array-Based Expression Analysis of Mouse Liver Genes: Effect of Age and of the Longevity Mutant Prop1df

2001 • 56 citations

Gene expression profiling in mitochondrial disease: assessment of microarray accuracy by high-throughput Q-PCR

2004 • 40 citations

Advances in spotted microarray resources for expression profiling

2003 • 17 citations

Customizing chemotherapy for colon cancer: the potential of gene expression profiling

2004 • 17 citations