Control of aromatase activity in breast tumours: the role of the immune system

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Human monocyte chemoattractant protein-1 (MCP-1)

1990 • 666 citations

Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative.

1993 • 577 citations

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.

1993 • 337 citations

Characterization of estrogen responsive transforming activity in human breast cancer cell lines.

1986 • 330 citations

Regulation of murine lymphokine production in vivo II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells

1990 • 324 citations

Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance

1994 • 286 citations

The importance of local synthesis of estrogen within the breast

1987 • 280 citations

Incidence of de-novo breast cancer in women chronically immunosuppressed after organ transplantation

1995 • 233 citations

Aromatase P450 Gene Expression in Human Adipose Tissue. ROLE OF A Jak/STAT PATHWAY IN REGULATION OF THE ADIPOSE-SPECIFIC PROMOTER

1995 • 229 citations

Aromatase activity and interleukin-6 production by normal and malignant breast tissues.

1995 • 193 citations

Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers.

1996 • 177 citations

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription [published erratum appears in J Clin Endocrinol Metab 1994 Feb;78(2):494]

1993 • 172 citations

Macrophages in human breast disease: a quantitative immunohistochemical study

1988 • 160 citations

Adverse life events and breast cancer: case-control study

1995 • 152 citations

Tissue-specific promoters regulate aromatase cytochrome P450 expression

1993 • 134 citations

ABNORMAL URINARY STEROID EXCRETION AND SUBSEQUENT BREAST CANCER

1967 • 118 citations

Control of aromatase activity in breast cancer cells: The role of cytokines and growth factors

1993 • 113 citations

Stimulation of aromatase activity in breast fibroblasts by tumor necrosis factor

1994 • 111 citations

INTERLEUKIN-1 AND INTERLEUKIN-6 IN BREAST CYST FLUID: THEIR ROLE IN REGULATING AROMATASE ACTIVITY IN BREAST CANCER CELLS

1992 • 96 citations

Interleukin 6 is secreted by breast fibroblasts and stimulates 17β‐oestradiol oxidoreductase activity of MCF‐7 cells: Possible paracrine regulation of breast 17β‐oestradiol levels

1991 • 77 citations

The interaction of cytokines in regulating oestradiol 17β-hydroxysteroid dehydrogenase activity in MCF-7 cells

1994 • 64 citations

Steroid modulation of aromatase activity in human cultured breast carcinoma cells

1988 • 63 citations

IS CANCER A MACROPHAGE-MEDIATED AUTOAGGRESSIVE DISEASE?

1987 • 59 citations

The role of aromatase in breast tumors

1994 • 55 citations

Steroid and growth factor modulation of aromatase activity in MCF7 and T47D breast carcinoma cell lines.

1992 • 54 citations

Pentoxifylline exerts synergistic immunomodulatory effects in combination with dexamethasone or cyclosporin A

1995 • 43 citations

The role of cytokines and sulphatase inhibitors in regulating oestrogen synthesis in breast tumours

1995 • 41 citations

Maturation of the Immune Response

1996 • 40 citations

The role and proposed mechanism by which oestradiol 17β-hydroxysteroid dehydrogenase regulates breast tumour oestrogen concentrations

1995 • 40 citations

Factors influencing aromatase activity in the breast

1993 • 40 citations

IL-6sR: RELEASE FROM MCF-7 BREAST CANCER CELLS AND ROLE IN REGULATING PERIPHERAL OESTROGEN SYNTHESIS

1995 • 38 citations

Enhancement of IL-6 receptor β chain (gp130) expression by IL-6, IL-1 and TNF in human epithelial cells

1992 • 38 citations

Immune surveillance and natural resistance: an evaluation

1986 • 36 citations

Regulation of aromatase and sulphatase in breast tumour cells.

1996 • 24 citations

The discriminant-function test: a marker of Th1/Th2 cell cytokine secretion and breast tumour oestrogen synthesis

1995 • 20 citations

A comparative study of cytokine gene transcripts in normal and malignant breast tissue and primary cell cultures derived from the same tissue samples

1996 • 19 citations

The challenge of breast cancer

1994 • 17 citations

Paracrine control of oestrogen production in breast cancer

1997 • 12 citations

Effects of Conditioned Medium from Different Cultured Cell Types on Aromatase Expression in Adipose Stromal Cells

1995 • 9 citations

Anti-tumour effect of aromatase inhibitor, CGS16949A, on human breast cancer cells

1995 • 8 citations