Immune surveillance and natural resistance: an evaluation

The Concept of Immunological Surveillance

2015 • 1,586 citations

Characteristics of human large granular lymphocytes and relationship to natural killer and K cells

1981 • 1,008 citations

Interleukin-2 augments natural killer cell activity

1981 • 921 citations

Interleukin 1, a potential regulator of fibroblast proliferation.

1982 • 835 citations

Enhanced NK cell activity in mice injected with interferon and interferon inducers

1978 • 735 citations

Suggestive Evidence That the “Blocking Antibodies” of Tumor-Bearing Individuals May Be Antigen-Antibody Complexes

1971 • 691 citations

Lymphocyte-Mediated Cytotoxicity And Blocking Serum Activity To Tumor Antigens

1974 • 651 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Role of NK cells in tumour growth and metastasis in beige mice

1980 • 524 citations

Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo.

1983 • 393 citations

Immunotherapy of Cancer: Regression of Intradermal Tumors and Prevention of Growth of Lymph Node Metastases After Intralesional Injection of Living <italic>Mycobacterium bovis</italic>

1972 • 355 citations

Immunological Surveillance in Neoplasia

1971 • 327 citations

Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivo.

1985 • 327 citations

EVIDENCE OF SUPPRESSOR CELL ACTIVITY IN SPLEENS OF MICE BEARING PRIMARY TUMORS INDUCED BY MOLONEY SARCOMA VIRUS

1974 • 325 citations

Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction

1978 • 296 citations

Blocking of Lymphocyte-mediated Cytotoxicity for Rat Hepatoma Cells by Tumour-specific Antigen-Antibody Complexes

1972 • 295 citations

Activation of antibody-dependent cell-mediated cytotoxicity of human neutrophils and eosinophils by separate colony-stimulating factors.

1983 • 248 citations

Deficient Natural Killer Cell Activity in X-Linked Lymphoproliferative Syndrome

1980 • 243 citations

Regulation of the immune response to tumor antigens. II. The nature of immunosuppressor cells in tumor-bearing hosts.

1976 • 239 citations

Retroviruses as etiologic agents of some animal and human leukemias and lymphomas and as tools for elucidating the molecular mechanism of leukemogenesis

1982 • 210 citations

Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: damage by purieid eosinophils.

1977 • 181 citations

De novo malignant tumors in organ transplant recipients.

1971 • 157 citations

Mechanism of rejection of virus persistently infected tumor cells by athymic nude mice.

1979 • 152 citations

In vivo significance of NK cell on resistance against virus (HSV-1) infections in mice.

1984 • 142 citations

Macrophage T lymphocyte interactions in the anti-tumor immune response: a mathematical model.

1985 • 141 citations

Final case reporting from the ugandan prospective study of the relationship between ebv and burktit's lymphoma

1982 • 133 citations

Tumor Immunity Produced by the Intradermal Inoculation of Living Tumor Cells and Living Mycobacterium bovis (Strain BCG)

1970 • 132 citations

Increase in NK cell number and turnover rate during acute viral infection.

1983 • 124 citations

MONOCLONAL ANTIBODIES AND CANCER

1982 • 123 citations

Chediak-Higashi syndrome. Observations on the nature of the associated malignancy.

1966 • 115 citations

Immunotherapy of cancer by systemic administration of lymphoid cells plus interleukin-2.

1984 • 112 citations

Correlation between Humoral Antibody and Regression of Tumours induced by Feline Sarcoma Virus

1971 • 111 citations

Two Functionally Distinct Anti-Tumor Effector Cells Isolated from Primary Murine Sarcoma Virus-Induced Tumors

1976 • 111 citations

Natural cytotoxicity in man: activity of lymph node and tumor‐infiltrating lymphocytes

1977 • 110 citations

Facilitation of polyoma tumor growth in rats by blocking sera and tumor eluate

1972 • 100 citations

The macrophage as an antineoplastic surveillance cell: biological perspectives.

1978 • 99 citations

Human natural cell-mediated cytotoxicity against fetal fibroblasts

1979 • 88 citations

Humoral and cellular factors in homograft and isograft immunity against sarcoma cells.

1960 • 87 citations

Killer T cells in a Burkitt's lymphoma biopsy

1975 • 84 citations

Human monocyte, lymphocyte, and granulocyte antibody-dependent cell-mediated cytotoxicity toward tumor cells. I. General characteristics of cytolysis.

1979 • 73 citations

Extravascular natural cytotoxicity in man: Anti‐K562 activity of lymph‐node and tumour‐infiltrating lymphocytes

1981 • 72 citations

Quantitation and clonal isolation of cytolytic T lymphocyte precursors selectively infiltrating murine sarcoma virus-induced tumors.

1981 • 72 citations

Treatment of disseminated leukemia with cyclophosphamide and immune cells: tumor immunity reflects long-term persistence of tumor-specific donor T cells.

1984 • 67 citations

Possible Evidence for Antibody-Dependent Macrophage-Mediated Cytotoxicity Directed against Murine Adenocarcinoma Cells in Vivo

1976 • 64 citations

Tumor-associated immunoglobulins. enhancement of syngeneic tumors by igg2-containing tumor eluates

1972 • 62 citations

Role of different T cells sets in the rejection of syngeneic chemically induced tumors.

1979 • 60 citations

In Vitro Activation of Mouse Macrophages by Rat Lymphocyte Mediators

1976 • 57 citations

Macrophage content and immunogenicity of C57BL/6J and BALB/cByJ methylcholanthrene‐induced sarcomas

1980 • 54 citations

Macrophages in Solid Tumors. I. Immunologically Specific Effector Cells 2

1974 • 54 citations

Cytolytic and cytostatic anti‐tumor activities of macrophages from mice injected with murine sarcoma virus

1979 • 52 citations

Serum factors modifying cell mediated immunity to rat hepatoma D23 correlated with tumour growth

1975 • 50 citations

Human natural cell-mediated cytotoxicity against fetal fibroblasts

1977 • 50 citations

The Biological Significance of Tumor-Bound Immunoglobulins

1973 • 50 citations

Do NK cells play a role in anti-tumor surveillance?

1980 • 50 citations

Separation and Characteristics of Tumor-Infiltrating Lymphocytes in Man

1980 • 46 citations

Inflammatory cells in solid murine neoplasms. IV. Cytolytic T lymphocytes isolated from regressing or progressing Moloney sarcomas.

1977 • 45 citations

Induction of Natural Killer Cell Activity and Allocytotoxicity in Human Peripheral Blood Lymphocytes after Mixed Lymphocyte Culture

1981 • 45 citations

Defective Natural Killer Activity Within Human Ovarian Tumors: Low Numbers of Morphologically Defined Effectors Present in Situ<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 41 citations

Antibody‐dependent cellular cytotoxicity against tumor cells. II. The promonocyte identified as effector cell

1979 • 41 citations

Long-Term Spontaneous Tumor Incidence in Neonatally Thymectomized Mice

1973 • 39 citations

Evidence for Mononuclear Phagocytes in Solid Neoplasms and Appraisal of Their Nonspecific Cytotoxic Capabilities

1980 • 34 citations

Immunologically Specific Activation of Macrophages Armed with the Specific Macrophage Arming Factor (SMAF)

1973 • 33 citations

Activated T lymphocytes within human solid tumors

1979 • 32 citations

Murine sarcoma virus (msv)‐induced tumors in mice. I. Distribution of msv‐immune cytolytic t lymphocytes in vivo

1977 • 29 citations

Differential immune reactivity of tumour-intrinsic and peripheral-blood lymphocytes against autoplastic colorectal carcinoma cells

1981 • 28 citations

Suppressor mechanisms in tumor immunity

1983 • 28 citations

I. Tumor growth in mice with depressed capacity to mount inflammatory responses: possible role of macrophages.

1981 • 28 citations

Natural cytotoxic macrophages in the peritoneal cavity of mice

1979 • 28 citations

Prolonged administration of antithymocyte serum in mice. I. Observations on cellular and humoral immunity.

1971 • 27 citations

Lung Carcinoma-Reactive Antibodies Isolated From Tumor Tissues and Pleural Effusions of Lung Cancer Patients<xref ref-type="fn" rid="FN2">2</xref>

1978 • 26 citations

In vitro antibody‐dependent cellular cytotoxicity against human T‐cell leukemia/lymphoma virus (HTLV)‐producing cells

1984 • 25 citations

Adoptive immunity to the guinea pig line 10 hepatoma and the nature of in vitro lymphoid-tumor cell interactions.

1981 • 25 citations

Demonstration of Immunoglobulin in Tumor and Marginal Tissues of Squamous Cell Carcinomas of the Head and Neck 2

1977 • 25 citations

Induction of polymorphonuclear leukocyte-mediated cytolysis by wheat germ agglutinin and antitumor antibody.

1983 • 24 citations

A clinical comparison between non-specific cross-reacting antigen and CEA in patients' sera

1977 • 23 citations

Regulation of the immune response to tumor antigens. IX. In vitro Lyt-1+2- cell proliferative responses to cellbound or subcellular tumor antigen.

1983 • 23 citations

Human tumor—lymphocyte interaction in vitro: Blastogenesis correlated to detectable immunoglobulin in the biopsy

1975 • 23 citations

Immunotherapy by Intralesional Injection of BCG Cell Walls or Live BCG in Bovine Ocular Squamous Cell Carcinoma: A Preliminary Report<xref ref-type="fn" rid="fn2">2</xref>

1982 • 22 citations

Therapy with allogeneic immune peritoneal cells.

1974 • 19 citations

Antibody‐dependent cellular cytotoxicity and disease course in North American patients with nasopharyngeal carcinoma: A prospective study

1984 • 18 citations

The significance of humoral antibodies in the localization of human malignant melanoma

1973 • 18 citations

Production of T‐cell lines with inhibitory or stimulatory activity against syngeneic tumors in vivo. A preliminary report

1981 • 17 citations

Host macrophages are involved in systemic adoptive immunity against tumors

1982 • 15 citations

Stimulation of lymphocytes by autochthonous cancer.

1972 • 15 citations

Natural Killing—Present and Future (Summary of Workshop on Natural Killer Cells)

1983 • 14 citations

T-Cell Involvement in Adoptive Transfer of Line 10 Tumor Immunity in Strain 2 Guinea Pigs

1985 • 12 citations

Beneficial and detrimental effects of humoral immunity in malignancy.

1978 • 12 citations

Tumor cells do not arise frequently

1985 • 11 citations

Immunoglobulins in eluates of malignant human tumours.

1973 • 10 citations

Major histocompatibility complex molecules as virus receptors

1984 • 9 citations

Phenotype of cytotoxic effector cells infiltrating a transplanted, chemically induced rat sarcoma.

1984 • 9 citations

Immunologic surveillance and human papillomaviruses

1984 • 8 citations

Lymphocyte-Induced Macrophage Cytotoxicity

1984 • 8 citations

Correlation between clinico-pathological features of malignant tumors and cell surface immunoglobulins.

1974 • 7 citations

Monocyte-mediated antibody-dependent cell-mediated cytotoxicity and spontaneous cytotoxicity in normals and cancer patients as assayed by human erythrocyte lysis.

1983 • 6 citations

An improved method of unit gravity sedimentation separation for murine peritoneal macrophage populations

1983 • 5 citations

Evidence for Membrane-Bound Antibodies Directed against Antigens Expressed on Tumors

1980 • 5 citations

Enhanced K-cell activity in the peripheral blood of patients with malignant disease

1984 • 3 citations

Decreased monocyte antibody-dependent cell-mediated toxicity in stage I?II malignant melanoma

1984 • 1 citations

Isolation, purification, and characterization of a mouse plasmacytoma cell surface glycoprotein involved in the resistance of the tumor cells to immune destruction.

1985 • 1 citations