Regulation of IgE synthesis in humans

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

1988 • 939 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

The Eosinophilic Leukocyte: Structure and Function

1986 • 828 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.

1988 • 791 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

IL-4 is required to generate and sustain in vivo IgE responses.

1988 • 671 citations

Molecular Regulation of B Lymphocyte Response

1988 • 579 citations

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

1986 • 514 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.

1987 • 449 citations

Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

1986 • 405 citations

T-cell and mast cell lines respond to B-cell stimulatory factor 1.

1986 • 381 citations

Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures.

1988 • 359 citations

Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.

1990 • 353 citations

Two species of human Fcε receptor II ( ): Tissue-specific and IL-4-specific regulation of gene expression

1988 • 345 citations

Perturbation of the T4 molecule transmits a negative signal to T cells.

1985 • 335 citations

Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.

1989 • 331 citations

Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins.

1988 • 327 citations

Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5).

1987 • 322 citations

Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression.

1987 • 320 citations

IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma.

1988 • 315 citations

Receptor-directed focusing of lymphokine release by helper T cells

1988 • 284 citations

Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage

1987 • 280 citations

Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes.

1988 • 280 citations

Molecular Mechanisms of Transmembrane Signaling in B Lymphocytes

1987 • 279 citations

Mitogen- and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching

1988 • 277 citations

Interleukin 5 enhances interleukin 4‐induced IgE production by normal human B cells. The role of soluble CD23 antigen

1988 • 265 citations

Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression.

1987 • 259 citations

Regulation and deregulation of human IgE synthesis

1990 • 254 citations

Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand

1987 • 251 citations

T cells can distinguish between allogeneic major histocompatibility complex products on different cell types

1988 • 246 citations

The role of IL-5 in IgA B cell differentiation.

1988 • 240 citations

Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells.

1987 • 237 citations

Characterization of the human B cell stimulatory factor 1 receptor.

1987 • 232 citations

Regulatory properties of LFA-1 α and β chains in human T-lymphocyte activation

1988 • 225 citations

Immunoglobulin Class Switching: Molecular and Cellular Analysis

1990 • 224 citations

Endogenous interleukin 6 plays an obligatory role in interleukin 4‐dependent human IgE synthesis

1989 • 221 citations

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

1986 • 220 citations

Fc receptors for IgE on human and rat eosinophils.

1981 • 215 citations

Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells

1988 • 211 citations

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

1987 • 209 citations

Expression and function of CD4 in a murine T-cell hybridoma

1987 • 208 citations

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.

1988 • 208 citations

Profiles of lymphokine activities and helper function for IgE in human T cell clones

1988 • 204 citations

Serum IgD and IgE concentrations in immunodeficiency diseases.

1975 • 193 citations

Biology of immunoglobulin E. Molecular basis of reaginic hypersensitivity.

1975 • 191 citations

Regulation of homocytotropic antibody formation in the rat. 3. Effect of thymectomy and splenectomy.

1971 • 183 citations

Possible role of human lymphocyte receptor for IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE.

1988 • 175 citations

IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma.

1989 • 167 citations

Structure and Function of Fc Receptors for IgE on Lymphocytes, Monocytes, and Macrophages

1984 • 157 citations

Hydrocortisone and IL-4 induce IgE isotype switching in human B cells.

1991 • 149 citations

Subpopulations of circulating B cells and regulatory T cells involved in in vitro immunoglobulin E production in atopic patients with elevted serum immunoglobulin E.

1980 • 132 citations

Functional heterogeneity among human inducer T cell clones.

1988 • 131 citations

Regulation of homocytotropic antibody formation in the rat. II. Effect of X-irradiation.

1971 • 124 citations

Characterization of the physical interaction between antigen-specific B and T cells.

1986 • 124 citations

Human IgE Biosynthesis in Vitro: Studies with Atopic and Normal Blood Mononuclear Cells and Subpopulations

1979 • 120 citations

Comparison of diversity and function of house dust mite‐specific T lymphocyte clones from atopic and non‐atopic donors

1990 • 113 citations

Interferon-gamma inhibits the action of B cell stimulatory factor (BSF)-1 on resting B cells.

1986 • 107 citations

Induction of human IgE synthesis by a factor derived from T cells of patients with hyper-IgE states.

1983 • 100 citations

Noncognate contact-dependent B cell activation can promote IL-4-dependent in vitro human IgE synthesis.

1990 • 87 citations

Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation.

1986 • 84 citations

Induction of germ-line and mature C epsilon transcripts in human B cells stimulated with rIL-4 and EBV.

1990 • 77 citations

Human IgE synthesis in vitro: a reassessment.

1981 • 70 citations

Regulation of homocytotropic antibody formation in the rat. IV. Effects of various immunosuppressive drugs.

1971 • 70 citations

Differential requirements of B cells from normal and allergic subjects for the induction of IgE synthesis by an alloreactive T cell clone.

1985 • 68 citations

Regulation of IgE synthesis in humans

1989 • 64 citations

In vitro production of IgE by human peripheral blood mononuclear cells. II. Cells involved in the spontaneous IgE production in atopic patients.

1980 • 63 citations

IgE synthesis by chronic lymphocytic leukemia cells.

1989 • 50 citations

Interleukin 4 induces changes in the chromatin structure of the gamma 1 switch region in resting B cells before switch recombination.

1990 • 49 citations

In vitro stimulation of IgE production at a single precursor level by human alloreactive T helper clones.

1984 • 48 citations

Autoreactive T cell clones of MHC class II specificities are produced during responses against foreign antigens in man.

1987 • 47 citations

Induction of IgG and IgE synthesis in normal B cells by autoreactive T cell clones.

1986 • 46 citations

Regulation of human immunoglobulin E synthesis in acute graft versus host disease.

1983 • 46 citations

Lack of pokeweed mitogen-induced IgE formation in vitro by human peripheral blood mononuclear cells: detection of cross-reacting idiotypic determinants on polyclonal Ig by antibodies to a single IgE myeloma protein.

1983 • 43 citations

Activation through CD3 molecule leads a number of human T cell clones to induce IgE synthesis in vitro by B cells from allergic and nonallergic individuals.

1987 • 41 citations

Filarial parasite-specific T cell lines: induction of IgE synthesis.

1985 • 37 citations

Increase of precursor frequency and clonal size of murine IgE-secreting cells by IL-4.

1988 • 36 citations

IgE synthesis in vitro induced by T cell factors from patients with elevated serum IgE levels.

1983 • 35 citations

Human T cell clones can induce in vitro IgE synthesis in normal B cells regardless of alloantigen recognition or specificity for peculiar antigens

1986 • 33 citations

Variability of IgE protein measurement in cell-culture supernatants: Results from a multicenter collaborative study

1986 • 26 citations

Control of IgE synthesis in man

1986 • 24 citations

Recognition by a human alloreactive T-cell clone of an HLA-DP-associated epitope on monocytes and fibroblasts but not on B cells

1988 • 8 citations