Neuroprotective Effect of Hypothermia on Neuronal Injury in Diffuse Traumatic Brain Injury Coupled With Hypoxia and Hypotension

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

THE ROLE OF SECONDARY BRAIN INJURY IN DETERMINING OUTCOME FROM SEVERE HEAD INJURY

1993 • 2,123 citations

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

Treatment of Traumatic Brain Injury with Moderate Hypothermia

1997 • 1,308 citations

A new model of diffuse brain injury in rats

1994 • 1,177 citations

Thresholds of focal cerebral ischemia in awake monkeys

1981 • 1,144 citations

Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain.

1989 • 1,110 citations

Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury

1990 • 1,080 citations

Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia

1991 • 726 citations

Experimental cerebral ischemia in Mongolian gerbils

1975 • 642 citations

Central nervous systems trauma and strokeI. Biochemical considerations for oxygen radical formation and lipid peroxidation

1989 • 626 citations

Initial CT findings in 753 patients with severe head injury

1990 • 589 citations

Marked Protection by Moderate Hypothermia after Experimental Traumatic Brain Injury

1991 • 529 citations

A new model of diffuse brain injury in rats

1994 • 528 citations

Changes in Cortical Extracellular Levels of Energy-Related Metabolites and Amino Acids following Concussive Brain Injury in Rats

1990 • 521 citations

Intraischemic but Not Postischemic Brain Hypothermia Protects Chronically following Global Forebrain Ischemia in Rats

1993 • 481 citations

Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography.

1993 • 467 citations

Progressive Atrophy and Neuron Death for One Year Following Brain Trauma in the Rat

1997 • 431 citations

Functional recovery of cortical neurons as related to degree and duration of ischemia

1983 • 396 citations

Effects of normothermic versus mild hyperthermic forebrain ischemia in rats.

1990 • 327 citations

Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat

1994 • 304 citations

Increased vulnerability of the midly traumatized rat brain to cerebral ischemia: the use of controlled secondary ischemia as a research tool to identify common or different mechanisms contributing to mechanical and ischemic brain injury

1989 • 277 citations

Characterization of edema by diffusion-weighted imaging in experimental traumatic brain injury

1996 • 271 citations

Avoidable factors contributing to death after head injury.

1977 • 270 citations

Diffuse brain swelling in severely head-injured children

1992 • 261 citations

HEAD INJURY AND BRAIN ISCHAEMIA - IMPLICATIONS FOR THERAPY

1985 • 246 citations

Differential regional vulnerability in transient focal cerebral ischemia.

1982 • 241 citations

Brain Hydroxyl Radical Generation in Acute Experimental Head Injury

1993 • 226 citations

Mild Pre- and Posttraumatic Hypothermia Attenuates Blood-Brain Barrier Damage Following Controlled Cortical Impact Injury in the Rat

1996 • 210 citations

Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat

1992 • 207 citations

The Threshold and Neuropathology of Cerebral "Anoxic-Ischemic" Cell Change

1973 • 200 citations

Magnetic resonance imaging—monitored acute blood-brain barrier changes in experimental traumatic brain injury

1996 • 197 citations

Direct Measurement of Hydroxyl Radicals, Lipid Peroxidation, and Blood–Brain Barrier Disruption Following Unilateral Cortical Impact Head Injury in the Rat

1994 • 195 citations

Chronic histopathological consequences of fluid-percussion brain injury in rats: effects of post-traumatic hypothermia

1997 • 191 citations

Protective effects of brain hypothermia on behavior and histopathology following global cerebral ischemia in rats

1992 • 180 citations

Mild hypothermic intervention after graded ischemic stress in rats.

1991 • 175 citations

The role of postischemic recirculation in the development of ischemic neuronal injury following complete cerebral ischemia

1981 • 151 citations

Dextran-Coupled Deferoxamine Improves Outcome in a Murine Model of Head Injury

1992 • 143 citations

Interrelationships between increased vascular permeability and acute neuronal damage following temperature-controlled brain ischemia in rats

1991 • 142 citations

Experimental cerebral ischemia in Mongolian gerbils

1976 • 142 citations

Posttraumatic hypothermia in the treatment of axonal damage in an animal model of traumatic axonal injury

1998 • 139 citations

The earliest alterations in rat neurones and astrocytes after anoxia-ischaemia

1973 • 131 citations

Effect of Hypoxia on Traumatic Brain Injury in Rats: Part 1

1987 • 123 citations

Neuronal ischemic injury: Light microscopy, ultrastructure and biochemistry

1978 • 122 citations

The Effect of Hypoxia on Traumatic Head Injury in Rats: Alterations in Neurologic Function, Brain Edema, and Cerebral Blood Flow

1987 • 120 citations

Increased Anticholinergic Sensitivity Following Closed Skull Impact and Controlled Cortical Impact Traumatic Brain Injury in the Rat

1994 • 105 citations

Breakdown of the Blood–Brain Barrier After Fluid Percussion Brain Injury in the Rat: Part 2: Effect of Hypoxia on Permeability to Plasma Proteins

1992 • 95 citations

Treatment of Experimental Brain Injury with Moderate Hypothermia and 21-Aminosteroids

1996 • 89 citations

The effects of hypovolemic hypotension on high-energy phosphate metabolism of traumatized brain in rats

1988 • 89 citations

Combined Pretrauma Scopolamine and Phencyclidine Attenuate Posttraumatic Increased Sensitivity to Delayed Secondary Ischemia

1988 • 84 citations

Systemic Hypothermia in Treatment of Severe Brain Injury: A Review and Update

1995 • 75 citations

Effect of Hypoxia on Traumatic Brain Injury in Rats: Part 2

1987 • 75 citations

The influence of hypoxia and hypotension on recovery from head injury

1972 • 63 citations

Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat

1994 • 57 citations

Clinical considerations in the reduction of secondary brain injury

1993 • 47 citations

Hypoxia and hypoxia/ischemia affect the expression of insulin-like growth factor binding protein 2 in the developing rat brain

1993 • 46 citations

The Cause of Acute Brain Swelling After the Closed Head Injury in Rats

1994 • 42 citations

Immediate Cerebrovascular Responses to Closed Head Injury in the Rat

1995 • 35 citations

Diaspirin Cross-Linked Hemoglobin Resuscitation Improves Cerebral Perfusion after Head Injury and Shock

1996 • 23 citations

Effect of Hypoxia or Hyperbaric Oxygen on Cerebral Edema following Moderate Fluid Percussion or Cortical Impact Injury in Rats

1995 • 23 citations