Treatment of Experimental Brain Injury with Moderate Hypothermia and 21-Aminosteroids

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury

1989 • 1,505 citations

Diffuse axonal injury and traumatic coma in the primate

1982 • 1,494 citations

A controlled cortical impact model of traumatic brain injury in the rat

1991 • 1,123 citations

Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain.

1989 • 1,110 citations

Central nervous systems trauma and strokeI. Biochemical considerations for oxygen radical formation and lipid peroxidation

1989 • 626 citations

Marked Protection by Moderate Hypothermia after Experimental Traumatic Brain Injury

1991 • 529 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage

1990 • 510 citations

Controlled Cortical Impact: A New Experimental Brain Injury Model

1988 • 465 citations

Effects of the 21-aminosteroid U74006F on experimental head injury in mice

1988 • 296 citations

Brain Hydroxyl Radical Generation in Acute Experimental Head Injury

1993 • 226 citations

Oxygen radicals in CNS damage

1989 • 226 citations

Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats.

1981 • 222 citations

Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat

1992 • 207 citations

Direct Measurement of Hydroxyl Radicals, Lipid Peroxidation, and Blood–Brain Barrier Disruption Following Unilateral Cortical Impact Head Injury in the Rat

1994 • 195 citations

Importance of Pharmacologic Considerations in the Evaluation of New Treatments for Acute Spinal Cord Injury

1992 • 188 citations

Effects of theN-Methyl-<scp>d</scp>-Aspartate Receptor Blocker MK-801 on Neurologic Function After Experimental Brain Injury

1989 • 183 citations

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

1987 • 180 citations

Traumatically Induced Reactive Change as Visualized Through the Use of Monoclonal Antibodies Targeted to Neurofilament Subunits

1992 • 172 citations

Hypothermia Attenuates the Loss of Hippocampal Microtubule-Associated Protein 2 (MAP2) following Traumatic Brain Injury

1993 • 104 citations

Therapeutic Hypothermia Is Cytoprotective without Attenuating the Traumatic Brain Injury-Induced Elevations in Interstitial Concentrations of Aspartate and Glutamate

1993 • 102 citations

The Novel 21-Aminosteroid U74006F Attenuates Cerebral Edema and Improves Survival after Brain Injury in the Rat

1992 • 98 citations

The effect of resuscitative moderate hypothermia following epidural brain compression on cerebral damage in a canineoutcome model

1993 • 93 citations

Inhibition of arachidonic acid-induced vasogenic brain edema by the non-glucocorticoid 21-aminosteroid U74006F

1988 • 80 citations

Lesions in the cerebral hemispheres after blunt head injury.

1970 • 75 citations

Acute Thrombotic Infarction Suppresses Metabolic Activation of Ipsilateral Somatosensory Cortex: Evidence for Functional Diaschisis

1989 • 65 citations

Hypothermia blunts acetylcholine increase in CSF of traumatically brain injured rats

1993 • 64 citations

The stabilization-lysis action of anti-inflammatory steroids on lysosomes

1970 • 47 citations

Effect of U74006F on Neurologic Function and Brain Edema After Fluid Percussion Injury in Rats

1993 • 43 citations

Hemodynamic Consequences of Common Carotid Artery Thrombosis and Thrombogenically Activated Blood in Rats

1991 • 39 citations

Secondary ischaemic brain damage after head injury.

1970 • 9 citations