Stereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

The heart and cardiovascular system

1986 • 1,333 citations

Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction

1989 • 995 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state.

1984 • 834 citations

Mechanism for Bupivacaine Depression of Cardiac Conduction

1985 • 444 citations

Toxicological and Local Anaesthetic Effects of Optically Active Isomers of Two Local Anaesthetic Compounds

1972 • 240 citations

Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels.

1985 • 239 citations

Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers

1995 • 164 citations

Antiarrhythmic drug action. Blockade of the inward sodium current.

1984 • 163 citations

Myocardial Uptake of Bupivacaine

1993 • 161 citations

Bupivacaine-induced Cardiac Arrhythmias in Sheep

1984 • 145 citations

Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea‐pig papillary muscle

1991 • 140 citations

Acute Cardiovascular Toxicity of Intravenous Amide Local Anesthetics in Anesthetized Ventilated Dogs

1982 • 140 citations

An intradermal study of the local anaesthetic and vascular effects of the isomers of bupivacaine.

1978 • 137 citations

Bupivacaine-Induced Cardiotoxicity in Hypoxic and Acidotic Sheep

1985 • 125 citations

Bupivacaine inhibits the transient outward K+ current but not the inward rectifier in rat ventricular myocytes.

1990 • 117 citations

The Action of Local Anesthetics on Ion Channels of Excitable Tissues

1987 • 116 citations

Stereoselective Inhibition of Neuronal Sodium Channels by Local Anesthetics Evidence For Two Sites of Action?

1992 • 111 citations

Phasic ion channel blockade. A kinetic model and parameter estimation procedure.

1985 • 108 citations

Characterization of cocaine-induced block of cardiac sodium channels

1990 • 104 citations

Optical isomers of mepivacaine and bupivacaine

1971 • 101 citations

Cardiovascular effects of convulsant and supraconvulsant doses of amide local anesthetics.

1982 • 94 citations

Evidence for two components of sodium channel block by lidocaine in isolated cardiac myocytes.

1988 • 82 citations

Cardiac Electrophysiologic Effects of Lidocaine and Bupivacaine

1988 • 76 citations

Differential Depressant and Electrophysiologic Cardiotoxicity of Local Anesthetics

1986 • 75 citations

Effects of quinidine on the sodium current of guinea pig ventricular myocytes. Evidence for a drug-associated rested state with altered kinetics.

1990 • 66 citations

Effect of Local Anesthetic Agents on Cardiac Conduction and Contractility

1981 • 65 citations

Effects of bupivacaine on membrane currents of guinea-pig ventricular myocytes

1988 • 62 citations

Cardiac Arrest Following Caudal Anesthesia

1979 • 61 citations

Long-acting Local Anesthetic Drugs and Convulsions with Hypoxia and Acidosis

1982 • 59 citations

Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaine

1990 • 58 citations

Toxicity and Systemic Effects of Local Anesthetic Agents

1987 • 55 citations

Imipramine blocks rapidly activating and delays slowly activating K+ current activation in guinea pig ventricular myocytes.

1994 • 49 citations

CURARE NEUROMUSCULAR BLOCKADE DURING HYPOTHERMIA IN MAN

1979 • 47 citations

The Influence of Acidosis on the Distribution of Lidocaine and Bupivacaine into the Myocardium and Brain of the Sheep

1987 • 46 citations

Comparative Inhibition of Voltage‐Gated Cation Channels by Local Anesthetics^a

1991 • 46 citations

Activation block and trapping of penticainide, a disopyramide analogue, in the Na+ channel of rabbit cardiac Purkinje fibers.

1988 • 38 citations

The Influence of Lactic Acid on the Serum Protein Binding of Bupivacaine

1984 • 34 citations

New insights into the pharmacology of sodium channel blockers

1992 • 29 citations

Nicorandil shortens action potential duration and antagonises the reduction of V max by lidocaine but not by disopyramide in guinea-pig papillary muscles

1988 • 27 citations

The Magnitude and Duration of Direct Myocardial Depression Following Intracoronary Local Anesthetics

1989 • 23 citations

Stereoselective block of cardiac sodium channels by RAC109 in single guinea pig ventricular myocytes.

1989 • 18 citations

EFFECTS OF NIMODIPINE ON NEUROLOGIC FUNCTION FOLLOWING COMPLETE GLOBAL ISCHEMIA IN PRIMATES

1984 • 12 citations

Prevention of Post-Extubation Larygospasm After Tonsilectomy

1979 • 11 citations

CARDIOVASCULAR EFFECTS OF NIFEDIPINE INFUSION DURING FENTANYL ANESTHESIA

1984 • 11 citations

THE INHIBITORY EFFECT OF HETOCLOPRAMIDE ON PLASMA CHOLINESTERASE ACTIVITY

1988 • 7 citations

FAILURE OF A RAPID INFUSION OF CRYSTALLOID TO INCREASE CEREBRAL BLOOD VOLUME AND INTRACRANIAL PRESSURE

1985 • 6 citations

THRESHOLD DETERMINATION FOR ICU QUALITY IMPROVEMENT PROGRAM CLINICAL INDICATORS

1992 • 4 citations

EFFECT OF PROPOFOL ON GUINEA PIG TRACHEAL SMOOTH MUSCLE

1989 • 4 citations

MODULATION OF HALOTHANE ACTION ON LIVER ADENYLATE CYCLASE

1982 • 3 citations