Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaine

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

Lidocaine block of cardiac sodium channels.

1983 • 660 citations

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

1973 • 660 citations

Lectures on Biostatistics.

1972 • 551 citations

Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs

1984 • 544 citations

Mechanism for Bupivacaine Depression of Cardiac Conduction

1985 • 444 citations

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

1975 • 387 citations

Membrane currents in isolated frog nerve fibre under voltage clamp conditions

1958 • 355 citations

Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics

1984 • 333 citations

Effect of procaine on electrical properties of squid axon membrane

1959 • 285 citations

Statistical properties of single sodium channels.

1984 • 280 citations

The pH-dependent rate of action of local anesthetics on the node of Ranvier.

1977 • 274 citations

Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle

1977 • 256 citations

The site of action and active form of local anesthetics. II. Experiments with quaternary compounds.

1970 • 221 citations

An Integrated view of the Molecular Toxinology of Sodium Channel Gating in Excitable Cells

1987 • 221 citations

Common Mode of Action of Three Agents that Decrease the Transient Change in Sodium Permeability in Nerves

1966 • 219 citations

The site of action and active form of local anesthetics. I. Theory and pH experiments with tertiary compounds.

1970 • 213 citations

Effect of lidocaine and quinidine on steady-state characteristics and recovery kinetics of (dV/dt)max in guinea pig ventricular myocardium.

1975 • 206 citations

Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons

1978 • 204 citations

Inhibition of sodium currents in frog ranvier node treated with local anesthetics Role of slow sodium inactivation

1976 • 200 citations

Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin

1979 • 197 citations

Gating of Na channels. Inactivation modifiers discriminate among models.

1987 • 150 citations

Phasic ion channel blockade. A kinetic model and parameter estimation procedure.

1985 • 108 citations

Block of sodium conductance and gating current in squid giant axons poisoned with quaternary strychnine

1979 • 104 citations

Ultra-slow inactivation of the ionic currents through the membrane of myelinated nerve

1976 • 100 citations

The rates of interaction of local anesthetics with sodium channels in nerve.

1978 • 89 citations

Irreversible modification of sodium channel inactivation in toad myelinated nerve fibres by the oxidant chloramine‐T.

1984 • 87 citations

Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation.

1987 • 75 citations

Block of Na channels in the membrane of myelinated nerve by benzocaine

1981 • 71 citations

Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axons

1985 • 71 citations

Sodium inactivation and drug-induced immobilization of the gating charge in nerve membrane

1981 • 67 citations

Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence

1990 • 65 citations

Blockade of rabbit atrial sodium channels by lidocaine. Characterization of continuous and frequency-dependent blocking.

1989 • 64 citations

Modeling ion channel blockade at guarded binding sites: application to tertiary drugs

1986 • 54 citations

Subconductance states of single sodium channels modified by chloramine-T and sea anemone toxin in neuroblastoma cells

1987 • 44 citations

Theoretical characterization of ion channel blockade. Competitive binding to periodically accessible receptors

1987 • 42 citations

The active form of local anesthetics

1962 • 41 citations

Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs

1984 • 37 citations

Action of benzocaine on sodium channels of frog nodes of ranvier treated with chloramine-T

1987 • 32 citations

The effect of local anaesthetics on the components of the asymmetry current in the squid giant axon.

1984 • 31 citations

Effects of benzocaine on the kinetics of normal and batrachotoxin-modified Na channels in frog node of Ranvier

1986 • 20 citations

Kinetics of intramembrane charge movement and conductance activation of batrachotoxin-modified sodium channels in frog node of Ranvier.

1985 • 15 citations

The mechanisms of sodium current inhibition by benzocaine in the squid giant axon

1987 • 13 citations

An Integrated View Of The Molecular Toxinology Of Sodium Channel Gating In Excitable Cells

1987 • 10 citations