Activation block and trapping of penticainide, a disopyramide analogue, in the Na+ channel of rabbit cardiac Purkinje fibers.

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

1971 • 930 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

Effects of calcium ions and local anaesthetics on electrical properties of Purkinje fibres

1955 • 708 citations

Lidocaine block of cardiac sodium channels.

1983 • 660 citations

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

1973 • 660 citations

Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics

1984 • 333 citations

CARDIAC MUSCLE

1968 • 332 citations

Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification

1983 • 279 citations

Cardiac Purkinje fibers: Cesium as a tool to block inward rectifying potassium currents

1976 • 241 citations

Effect of lidocaine and quinidine on steady-state characteristics and recovery kinetics of (dV/dt)max in guinea pig ventricular myocardium.

1975 • 206 citations

Slow inactivation of the sodium current in rabbit cardiac Purkinje fibres

1987 • 140 citations

Acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites

1983 • 77 citations

Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axons

1985 • 71 citations

Effects of tocainide and lidocaine on the transmembrane action potentials as related to external potassium and calcium concentrations in guinea-pig papillary muscles

1980 • 66 citations

Voltage-dependent block by tetrodotoxin of the sodium channel in rabbit cardiac Purkinje fibers

1987 • 58 citations

Modeling ion channel blockade at guarded binding sites: application to tertiary drugs

1986 • 54 citations

Mechanisms of quinidine-induced depression of maximum upstroke velocity in ovine cardiac Purkinje fibers.

1982 • 49 citations

Slow recovery of the maximal rate of rise ( $$\dot V_{max} $$ ) of the action potential in sheep cardiac Purkinje fibers

1982 • 43 citations

Effect of procainamide on transmembrane action potentials in guinea-pig papillary muscles as affected by external potassium concentration

1979 • 41 citations

Molecular and structural basis of resting and use-dependent block of sodium current defined using disopyramide analogues

1987 • 35 citations

A quantitative description of QX222 blockade of sodium channels in squid axons

1986 • 33 citations

Synthesis and antiarrhythmic activity of new [(dialkylamino)alkyl]pyridylacetamides

1983 • 23 citations

Electrophysiological Studies of Penticainide (CM 7857), a New Antiarrhythmic Agent, in Mammalian Myocardium

1987 • 18 citations

Disopyramide phosphate: is it just another quinidine

1978 • 17 citations

Significance of bicarbonate for antiarrhythmic drug action

1981 • 13 citations