Cholangiocarcinoma: Current concepts and insights

The Hallmarks of Cancer

2000 • 27,569 citations

Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference

2001 • 4,068 citations

Staging, Resectability, and Outcome in 225 Patients With Hilar Cholangiocarcinoma

2001 • 1,278 citations

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

2001 • 1,063 citations

Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States

2001 • 989 citations

The INK4a/ARF network in tumour suppression

2001 • 956 citations

Hepatic and extrahepatic malignancies in primary sclerosing cholangitis

2002 • 682 citations

Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus document

2002 • 640 citations

Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.

2000 • 640 citations

Changing international trends in mortality rates for liver, biliary and pancreatic tumours

2002 • 550 citations

Unilateral versus bilateral endoscopic hepatic duct drainage in patients with malignant hilar biliary obstruction: Results of a prospective, randomized, and controlled study

2001 • 426 citations

Hepatogastroenterology

2012 • 421 citations

The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis

2000 • 405 citations

Cholangiocarcinoma Complicating Primary Sclerosing Cholangitis

1991 • 400 citations

Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968–1998

2001 • 371 citations

Prolonged disease-free survival after orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma

2000 • 365 citations

Resection or palliation: Priority of surgery in the treatment of hilar cancer

1988 • 332 citations

Cholangiocarcinoma in patients with primary sclerosing cholangitis: A multicenter case-control study

2000 • 330 citations

Radiochemotherapy and Transplantation Allow Long‐Term Survival For Nonresectable Hilar Cholangiocarcinoma

2002 • 299 citations

Cholangiocarcinoma in Primary Sclerosing Cholangitis: Risk Factors and Clinical Presentation

2002 • 296 citations

Cell senescence and cancer

2001 • 292 citations

Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis

2001 • 280 citations

Photodynamic therapy of nonresectable cholangiocarcinoma

1998 • 265 citations

Positron emission tomography with [18F]fluoro-2-deoxy-D-glucose for diagnosis and staging of bile duct cancer

2001 • 263 citations

Late Development of Bile Duct Cancer in Patients Who Had Biliary-Enteric Drainage for Benign Disease: A Follow-Up Study of More Than 1,000 Patients

2001 • 238 citations

“Natural History” of Unresected Cholangiocarcinoma: Patient Outcome After Noncurative Intervention

1995 • 235 citations

Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor.

2002 • 229 citations

Liver transplantation for cholangiocellular carcinoma: Analysis of a single-center experience and review of the literature

2001 • 217 citations

Diagnostic Role of Serum CA 19-9 for Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis

1993 • 216 citations

Cholangiocarcinoma: Recent progress. Part 1: Epidemiology and etiology

2002 • 212 citations

Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line

1999 • 208 citations

Detection of cholangiocarcinoma in primary sclerosing cholangitis by positron emission tomography

1998 • 206 citations

Photodynamic therapy for advanced bile duct cancer: Evidence for improved palliation and extended survival

2000 • 201 citations

Frequency of p16INK4A alterations and k-ras mutations in intrahepatic cholangiocarcinoma of the liver

2000 • 196 citations

ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions

2002 • 188 citations

Incidence of benign lesions in patients resected for suspicious hilar obstruction

2001 • 187 citations

Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line

2002 • 183 citations

Constitutive expression of ErbB-2 in gallbladder epithelium results in development of adenocarcinoma.

2001 • 170 citations

Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage.

2003 • 169 citations

Magnetic resonance cholangiography in patients with biliary disease: its role in primary sclerosing cholangitis

2000 • 160 citations

FDG PET in the diagnosis of hilar cholangiocarcinoma

2001 • 157 citations

Marked Elevation of Serum Interleukin-6 in Patients With Cholangiocarcinoma

1998 • 145 citations

Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma.

1996 • 142 citations

Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9.

2002 • 137 citations

Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm

2001 • 128 citations

Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis.

2002 • 119 citations

Early detection and treatment of cholangiocarcinoma

2000 • 116 citations

Endoscopic application of photodynamic therapy for cholangiocarcinoma

2001 • 113 citations

Biliary dysplasia as a marker of cholangiocarcinoma in primary sclerosing cholangitis

2001 • 100 citations

p16INK4a Promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma

2002 • 95 citations

Liver cancer in Thailand. II. A case‐control study of hepatocellular carcinoma

1991 • 92 citations

Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.

2002 • 90 citations

Cyclooxygenase-2 and ERBB-2 in Cholangiocarcinoma: Potential Therapeutic Targets

2002 • 88 citations

Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism.

2002 • 84 citations

Overexpression of C-NEU and C-MET during rat liver cholangiocarcinogenesis: A link between biliary intestinal metaplasia and mucin-producing cholangiocarcinoma

1999 • 83 citations

Chromosome 9p21 Loss and p16 Inactivation in Primary Sclerosing Cholangitis-Associated Cholangiocarcinoma

1999 • 82 citations

Genetic and epigenetic alterations of the INK4a–ARF pathway in cholangiocarcinoma

2002 • 82 citations

Improved Diagnostic Yield of Endoscopic Biliary Brush Cytology by Digital Image Analysis

2001 • 81 citations

Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development

2000 • 79 citations

Cholangiocarcinoma: Recent progress. Part 2: Molecular pathology and treatment

2002 • 76 citations

p53 overexpression and K- ras gene mutations in primary sclerosing cholangitis-associated biliary tract cancer

2000 • 69 citations

SHORT COMMUNICATION: Promotion of cholangiocarcinogenesis in the hamster liver by bile duct ligation after dimethylnitrosamine initiation

1993 • 64 citations

Multiple genetic alterations involved in the tumorigenesis of human cholangiocarcinoma: a molecular genetic and clinicopathological study

2001 • 57 citations

K-ras mutations in the bile of patients with primary sclerosing cholangitis

2001 • 57 citations

Microsatellite instability and alternative genetic pathway in intrahepatic cholangiocarcinoma

2001 • 56 citations

Nonoperative approach to hilar cancer determined by the atrophy-hypertrophy complex

1989 • 49 citations

Detection of telomerase activity in biopsy specimens for diagnosis of biliary tract cancers

2000 • 49 citations

Inactivation of the INK4a/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines

2001 • 48 citations

E-cadherin gene mutations in human intrahepatic cholangiocarcinoma

2001 • 39 citations

Cholangiocarcinoma arising after biliary-enteric drainage procedures for benign disease

2002 • 36 citations

Microsatellite alterations in liver fluke related cholangiocarcinoma are associated with poor prognosis

2002 • 33 citations

Detection of telomerase reverse transcriptase mRNA in biopsy specimens and bile for diagnosis of biliary tract cancers

2001 • 27 citations

Cholangiocarcinoma: The “Other” Liver Cancer on the Rise

2002 • 25 citations

Ultrastructural and immunohistochemical analysis of cholangiocarcinoma in immunized Syrian golden hamsters infected with Opisthorchis viverrini and administered with dimethylnitrosamine

2000 • 24 citations

Induction of cholangiocarcinoma in the Golden Syrian hamster using methylazoxymethyl acetate.

1992 • 12 citations

Increased telomerase activity in intrahepatic cholangiocellular carcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters

1998 • 10 citations