Structure−Function Studies of the Brain-Type Glucose Transporter, GLUT3: Alanine-Scanning Mutagenesis of Putative Transmembrane Helix VIII and an Investigation of the Role of Proline Residues in Transport Catalysis

The glucose transporter family: structure, function and tissue-specific expression

1993 • 773 citations

Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).

1990 • 389 citations

Facilitative glucose transporters: an expanding family

1990 • 316 citations

Mammalian passive glucose transporters: members of an ubiquitous family of active and passive transport proteins

1993 • 279 citations

Amino acid substitutions at tryptophan 388 and tryptophan 412 of the HepG2 (Glut1) glucose transporter inhibit transport activity and targeting to the plasma membrane in Xenopus oocytes.

1992 • 170 citations

Glucose transporter oligomeric structure determines transporter function. Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1.

1992 • 168 citations

Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors

1993 • 166 citations

Functional expression of the human HepG2 and rat adipocyte glucose transporters in Xenopus oocytes

1989 • 141 citations

Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding.

1992 • 86 citations

Processing of precursors by dipeptidylaminopeptidases: a case of molecular ticketing

1990 • 83 citations

Replacement of intracellular C-terminal domain of GLUT1 glucose transporter with that of GLUT2 increases Vmax and Km of transport activity.

1992 • 61 citations

Proposed structure of putative glucose channel in GLUT1 facilitative glucose transporter

1996 • 54 citations

Substitution of leucine for tryptophan 412 does not abolish cytochalasin B labeling but markedly decreases the intrinsic activity of GLUT1 glucose transporter.

1991 • 54 citations

Substitution at Pro385 of GLUT1 perturbs the glucose transport function by reducing conformational flexibility.

1994 • 52 citations

Facilitative Glucose Transporters

1997 • 39 citations

Functional Consequences of Proline Mutations in the Putative Transmembrane Segments 6 and 10 of the Glucose Transporter GLUT1

1995 • 23 citations

Structural Topology of Transmembrane Helix 10 in the Lactose Permease of Escherichia coli

1996 • 6 citations