Acute Glutathione Depletion Restricts Mitochondrial ATP Export in Cerebellar Granule Neurons

Free Radicals in the Physiological Control of Cell Function

2002 • 9,561 citations

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

2001 • 4,399 citations

Oxidative stress in neurodegeneration: cause or consequence?

2004 • 1,803 citations

Mitochondria and Neuronal Survival

2000 • 1,206 citations

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

2004 • 1,045 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Mitochondrial permeability transition and oxidative stress

2001 • 842 citations

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis

2003 • 748 citations

Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators

2004 • 745 citations

Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications

2004 • 589 citations

The Adenine Nucleotide Translocase: A Central Component of the Mitochondrial Permeability Transition Pore and Key Player in Cell Death

2003 • 491 citations

Redox Potentials of Glutaredoxins and Other Thiol-Disulfide Oxidoreductases of the Thioredoxin Superfamily Determined by Direct Protein-Protein Redox Equilibria

1997 • 403 citations

Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ

1980 • 391 citations

Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore

2002 • 355 citations

Glutathione redox potential in response to differentiation and enzyme inducers

1999 • 351 citations

Physiological roles of nicotinamide nucleotide transhydrogenase

1988 • 348 citations

A Reevaluation of the Role of Mitochondria in Neuronal Ca²⁺ Homeostasis

1996 • 347 citations

Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species

1997 • 336 citations

Monitoring disulfide bond formation in the eukaryotic cytosol

2004 • 317 citations

Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

2000 • 308 citations

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

2000 • 286 citations

High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function.

1990 • 283 citations

Mitochondrial Dysfunction and Glutamate Excitotoxicity Studied in Primary Neuronal Cultures

2004 • 265 citations

Monochlorobimane Fluorometric Method to Measure Tissue Glutathione

2000 • 254 citations

Glutathione Depletion in PC12 Results in Selective Inhibition of Mitochondrial Complex I Activity

2000 • 253 citations

The Glutathione System of Peroxide Detoxification Is Less Efficient in Neurons than in Astroglial Cells

1999 • 232 citations

The use of monochlorobimane to determine hepatic GSH levels and synthesis

1990 • 214 citations

Deoletion of brain glutathione is accompanied by impaired micochondrial function and decreased N-acetyl aspartate concentration

1995 • 186 citations

Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function

1999 • 184 citations

Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress

2002 • 165 citations

The Integration of Mitochondrial Calcium Transport and Storage

2004 • 157 citations

Protection Against Ischemic Brain Injury by Inhibition of Mitochondrial Oxidative Stress

2004 • 155 citations

In Situ Respiration and Bioenergetic Status of Mitochondria in Primary Cerebellar Granule Neuronal Cultures Exposed Continuously to Glutamate

2004 • 143 citations

The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells

1990 • 140 citations

Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis

1999 • 134 citations

Vulnerability of Central Neurons to Secondary Insults afterIn VitroMechanical Stretch

2004 • 131 citations

Evidence for Redox Regulation of Cytochrome c Release during Programmed Neuronal Death: Antioxidant Effects of Protein Synthesis and Caspase Inhibition

2001 • 127 citations

Characterization of cysteine residues of mitochondrial ADP/ATP carrier with the SH-reagents eosin 5-maleimide and N-ethylmaleimide.

1993 • 124 citations

Evaluation of fluorescent dyes for measuring intracellular glutathione content in primary cultures of human neurons and neuroblastoma SH‐SY5Y

2002 • 123 citations

Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane

2001 • 116 citations

Translocation of Loops Regulates Transport Activity of Mitochondrial ADP/ATP Carrier Deduced from Formation of a Specific Intermolecular Disulfide Bridge Catalyzed by Copper-o-Phenanthroline

1995 • 106 citations

Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO‐mediated pathway not involving peroxynitrite: implications for Parkinson's disease

2005 • 103 citations

Oxidative changes in brain pyridine nucleotides and neuroprotection using nicotinamide

2001 • 92 citations

The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells

2001 • 88 citations

Highly Selective and Prolonged Depletion of Mitochondrial Glutathione in Astrocytes Markedly Increases Sensitivity to Peroxynitrite

2004 • 86 citations

The effects of focal ischemia and reperfusion on the glutathione content of mitochondria from rat brain subregions

2002 • 82 citations

Glutathione monoethyl ester provides neuroprotection in a rat model of stroke

2003 • 80 citations

Differential effects of l-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells

1999 • 75 citations

Importance of Loops of Mitochondrial ADP/ATP Carrier for Its Transport Activity Deduced from Reactivities of its Cysteine Residues with the Sulfhydryl Reagent Eosin-5-maleimide

1994 • 68 citations

Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate

2004 • 65 citations

Glutathione depletion switches nitric oxide neurotrophic effects to cell death in midbrain cultures: implications for Parkinson's disease

2001 • 64 citations

Mitochondria Control AMPA/Kainate Receptor-Induced Cytoplasmic Calcium Deregulation in Rat Cerebellar Granule Cells

2001 • 60 citations

Ceramides increase the activity of the secretory phospholipase A2 and alter its fatty acid specificity

2002 • 59 citations

Brevetoxins cause acute excitotoxicity in primary cultures of rat cerebellar granule neurons.

1999 • 55 citations

Kinetic analysis of glutathione in anchored cells with monochlorobimane

1995 • 54 citations

Cytochrome bc1 Regulates the Mitochondrial Permeability Transition by Two Distinct Pathways

2004 • 51 citations

Measurement of the intracellular distribution of reduced glutathione in cultured rat hepatocytes using monochlorobimane and confocal laser scanning microscopy

2002 • 47 citations

Effects of ethacrynic acid and furosemide on isolated rat kidney mitochondria: inhibition of electron transport in the region of phosphorylation site II.

1976 • 31 citations

The Characterization of Mitochondrial Permeability Transition in Clonal Pancreatic β-Cells

2004 • 26 citations

Menadione induces a low conductance state of the mitochondrial inner membrane sensitive to bongkrekic acid

2004 • 19 citations