Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Caspases: Enemies Within

1998 • 6,923 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody

1996 • 354 citations

Rescue of cells from apoptosis by inhibition of active GSH extrusion

1998 • 320 citations

Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance.

1996 • 278 citations

Induction of the Mitochondrial Permeability Transition Causes Release of the Apoptogenic Factor Cytochrome c

1998 • 216 citations

Non-oxidative Loss of Glutathione in Apoptosis via GSH Extrusion

1995 • 190 citations

Methods for Biochemical Study of Poly(ADP-Ribose) Metabolism in Vitro and in Vivo

1995 • 177 citations

Multiple Pathways for Apoptotic Nuclear Fragmentation

1996 • 157 citations

Apoptosis in the Absence of Cytochrome c Accumulation in the Cytosol

1998 • 119 citations

Protease inhibitors block apoptosis at intermediate stages: a compared analysis of DNA fragmentation and apoptotic nuclear morphology

1995 • 51 citations

Apoptosis-prone phenotype of human colon carcinoma cells with a high level amplification of the c-myc gene

1999 • 48 citations

dATP Causes Specific Release of Cytochrome C from Mitochondria

1998 • 47 citations

Proton Translocation Linked to the Activity of the Bi-Trans-membrane Electron Transport Chain

1995 • 25 citations