Characterization of a p75NTR Apoptotic Signaling Pathway Using a Novel Cellular Model

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

Apoptosis in the nervous system

2000 • 1,850 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

Functions of the neurotrophins during nervous system development: What the knockouts are teaching us

1994 • 1,431 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Bcl-2 family proteins

1998 • 1,055 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75

1996 • 768 citations

Induction of cell death by endogenous nerve growth factor through its p75 receptor

1996 • 750 citations

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

2000 • 650 citations

Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

1994 • 583 citations

Target Protease Specificity of the Viral Serpin CrmA

1997 • 517 citations

Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth

1999 • 516 citations

The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death

1998 • 500 citations

Mechanisms of programmed cell death in the developing brain

2000 • 437 citations

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1997 • 433 citations

Wild-Type Huntingtin Protects from Apoptosis Upstream of Caspase-3

2000 • 389 citations

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

1996 • 379 citations

A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis

1997 • 343 citations

Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

1997 • 327 citations

NMR structure of the death domain of the p75 neurotrophin receptor

1997 • 301 citations

The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins

1994 • 294 citations

NRAGE, A Novel MAGE Protein, Interacts with the p75 Neurotrophin Receptor and Facilitates Nerve Growth Factor–Dependent Apoptosis

2000 • 287 citations

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases

1995 • 281 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

Association of the p75 Neurotrophin Receptor with TRAF6

1999 • 237 citations

The p75 neurotrophin receptor and neuronal apoptosis

2000 • 219 citations

Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis

1997 • 208 citations

NADE, a p75NTR-associated Cell Death Executor, Is Involved in Signal Transduction Mediated by the Common Neurotrophin Receptor p75NTR

2000 • 202 citations

Neuronal Apoptosis Induced by β-Amyloid Is Mediated by Caspase-8

1999 • 186 citations

The zinc finger protein NRIF interacts with the neurotrophin receptor p75NTR and participates in programmed cell death

1999 • 185 citations

TRAF Family Proteins Interact with the Common Neurotrophin Receptor and Modulate Apoptosis Induction

1999 • 185 citations

Association of p75 with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to Caveolae

1997 • 169 citations

Oligodendrocyte Apoptosis Mediated by Caspase Activation

1999 • 161 citations

Generation and characterization of embryonic striatal conditionally immortalized ST14A cells

1998 • 138 citations

Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor

1999 • 128 citations

Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy.

2000 • 127 citations

Nerve Growth Factor Signaling through p75 Induces Apoptosis in Schwann Cells via a Bcl-2-Independent Pathway

1999 • 126 citations

Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death

2000 • 120 citations

Focal cerebral ischemia in rats induces expression of p75 neurotrophin receptor in resistant striatal cholinergic neurons

1998 • 115 citations

p75 neurotrophin receptor as a modulator of survival and death decisions

1999 • 110 citations

Nerve Growth Factor Activation of Nuclear Factor κB through Its p75 Receptor Is an Anti-apoptotic Signal in RN22 Schwannoma Cells

2000 • 106 citations

Induction of Postnatal Schwann Cell Death by the Low-Affinity Neurotrophin ReceptorIn Vitroand after Axotomy

2000 • 102 citations

The three-dimensional solution structure and dynamic properties of the human FADD death domain 1 1Edited by A. Fersht

2000 • 96 citations

Separate Domains of the Human Fas Ligand Dictate Self-association and Receptor Binding

1997 • 82 citations

Functional interaction of Fas‐associated phosphatase‐1 (FAP‐1) with p75^NTR and their effect on NF‐κB activation

1999 • 78 citations

ST14A Cells Have Properties of a Medium-Size Spiny Neuron

2001 • 76 citations

Systematic Mutational Analysis of the Death Domain of the Tumor Necrosis Factor Receptor 1-associated Protein TRADD

1996 • 73 citations

Reducing p75 nerve growth factor receptor levels using antisense oligonucleotides prevents the loss of axotomized sensory neurons in the dorsal root ganglia of newborn rats

1996 • 72 citations

Review:Death Domain Receptors and Their Role in Cell Demise

1998 • 62 citations

p75 Neurotrophin Receptor-mediated Neuronal Death Is Promoted by Bcl-2 and Prevented by Bcl-xL

1999 • 56 citations

Evidence for the Involvement of Par-4 in Ischemic Neuron Cell Death

2001 • 48 citations

A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor

1999 • 40 citations

Nerve growth factor stimulates MAPK via the low affinity receptor p75^LNTR

1999 • 39 citations

Sympathetic and sensory innervation of the extracerebral vasculature: Roles for p75NTR neuronal expression and nerve growth factor

1998 • 39 citations

Expression of neurotrophins and their receptors in the developing and adult rat adrenal gland

1996 • 36 citations

Attenuation of a Caspase-3 Dependent Cell Death in NT4- and p75-Deficient Embryonic Sensory Neurons

2000 • 29 citations

Involvement of Cytoplasmic Serine Proteinase and CPP32 Subfamily in the Molecular Machinery of Caspase 3 Activation during Fas-Mediated Apoptosis

1997 • 29 citations

Systemic administration of antisense p75^NTR oligodeoxynucleotides rescues axotomised spinal motor neurons

2001 • 28 citations

Apoptosis is antagonized by large T antigens in the pathway to immortalization by polyomaviruses.

1994 • 20 citations

Suppression of Interleukin-1β converting enzyme (ICE)-induced apoptosis by SV40 large T antigen

1997 • 17 citations

Characterization of neurons containing nerve growth factor receptors in the rat neostriatum

1989 • 16 citations

Polyomavirus large T-antigen protects mouse cells from Fas-, TNF-α- and taxol-induced apoptosis

2000 • 11 citations