Retinoid Signaling in Vertebrate Limb Developmenta

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

The Retinoids-Biology, Chemistry and Medicine

1994 • 987 citations

Identification and spatial distribution of retinoids in the developing chick limb bud

1987 • 964 citations

Hox genes and the evolution of vertebrate axial morphology

1995 • 825 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

1993 • 738 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

Chapter 6 Positional Information and Pattern Formation

1971 • 663 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Fibroblast growth factors induce additional limb development from the flank of chick embryos

1995 • 578 citations

Induction of the LIM homeobox gene Lmx1 by WNT6a establishes dorsoventral pattern in the vertebrate limb

1995 • 469 citations

A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1

1994 • 446 citations

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

1991 • 394 citations

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

1990 • 351 citations

Activin signalling and response to a morphogen gradient

1994 • 328 citations

Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning

1995 • 318 citations

A quantitative analysis of the effect of all-trans-retinoic acid on the pattern of chick wing development

1985 • 312 citations

Developmental expression of murine retinoid X receptor (RXR) genes

1994 • 297 citations

Polarizing activity and retinoid synthesis in the floor plate of the neural tube

1990 • 292 citations

Dorsal cell fate specified by chick Lmxl during vertebrate limb development

1995 • 287 citations

Developmental analysis of the retinoic acid-inducible RAR-βJ2 promoter in transgenic animals

1991 • 258 citations

Retinoids and vertebrate limb pattern formation

1989 • 251 citations

Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay

1992 • 250 citations

Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud

1991 • 242 citations

Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development

1991 • 223 citations

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud

1991 • 218 citations

Evidence that Hensen's node is a site of retinoic acid synthesis

1992 • 216 citations

The effect of local application of retinoic acid to the anterior margin of the developing chick limb

1983 • 210 citations

The number of polarizing region cells required to specify additional digits in the developing chick wing

1981 • 209 citations

Vertebrate Limb Development

1994 • 204 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

The initiation of the limb bud: Growth factors, Hox genes, and retinoids

1995 • 170 citations

Direct and continuous assessment by cells of their position in a morphogen gradient

1995 • 150 citations

Retinoic acid signaling is required during early chick limb development

1996 • 132 citations

A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos

1988 • 105 citations

Homeobox genes and pattern formation in the vertebrate limb

1992 • 103 citations

Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud

1994 • 97 citations

A retinoic acid-triggered cascade of HOXB1 gene activation.

1995 • 83 citations

The spatial and temporal distribution of polarizing activity in the flank of the pre-limb-bud stages in the chick embryo

1991 • 65 citations

9-cis-retinoic acid, a potent inducer of digit pattern duplications in the chick wing bud

1993 • 57 citations

Views of limb development and regeneration

1986 • 46 citations

Evidence for a positional memory in the development of the chick wing bud.

1979 • 37 citations

Evidence for a positional memory in the development of the chick wing bud

1979 • 31 citations

Induction of Polarizing Activity by Retinoic Acid Occurs Independently of Duplicate Formation in Developing Chick Limb Buds

1993 • 20 citations

Hensen's node, but not other biological signallers, can induce supernumerary digits in the developing chick limb bud

1990 • 18 citations

Digit Induction by Hensen's Node and Notochord Involves the Expression ofshhbut NotRAR-β2

1996 • 8 citations